PCID2_BOVIN
ID PCID2_BOVIN Reviewed; 408 AA.
AC Q2TBN6;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=PCI domain-containing protein 2;
DE AltName: Full=CSN12-like protein;
GN Name=PCID2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for B-cell survival through the regulation of the
CC expression of cell-cycle checkpoint MAD2L1 protein during B cell
CC differentiation (By similarity). As a component of the TREX-2 complex,
CC involved in the export of mRNAs to the cytoplasm through the nuclear
CC pores (By similarity). Binds and stabilizes BRCA2 and is thus involved
CC in the control of R-loop-associated DNA damage and transcription-
CC associated genomic instability. R-loop accumulation does not increase
CC in PCID2-depleted cells (By similarity).
CC {ECO:0000250|UniProtKB:Q5JVF3}.
CC -!- SUBUNIT: Component of the nuclear pore complex (NPC)-associated TREX-2
CC complex (transcription and export complex 2), composed of at least
CC GANP, 2 copies of ENY2, PCID2, SEM1/DSS1, and either centrin CETN2 or
CC centrin CETN3. The TREX-2 complex also associates with ALYREF/ALY and
CC with the nucleoporin NUP153 (By similarity). Interacts with BRCA2 (By
CC similarity). {ECO:0000250|UniProtKB:Q5JVF3}.
CC -!- SIMILARITY: Belongs to the CSN12 family. {ECO:0000305}.
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DR EMBL; BC109884; AAI09885.1; -; mRNA.
DR RefSeq; NP_001033674.1; NM_001038585.2.
DR AlphaFoldDB; Q2TBN6; -.
DR SMR; Q2TBN6; -.
DR STRING; 9913.ENSBTAP00000028959; -.
DR PaxDb; Q2TBN6; -.
DR PRIDE; Q2TBN6; -.
DR GeneID; 617943; -.
DR KEGG; bta:617943; -.
DR CTD; 55795; -.
DR eggNOG; KOG2688; Eukaryota.
DR InParanoid; Q2TBN6; -.
DR OrthoDB; 706700at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0044615; C:nuclear pore nuclear basket; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0070390; C:transcription export complex 2; ISS:UniProtKB.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR GO; GO:2000117; P:negative regulation of cysteine-type endopeptidase activity; ISS:UniProtKB.
DR GO; GO:1905457; P:negative regulation of lymphoid progenitor cell differentiation; ISS:UniProtKB.
DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central.
DR GO; GO:0090267; P:positive regulation of mitotic cell cycle spindle assembly checkpoint; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0000973; P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery; IBA:GO_Central.
DR GO; GO:1900049; P:regulation of histone exchange; ISS:UniProtKB.
DR GO; GO:0043488; P:regulation of mRNA stability; ISS:UniProtKB.
DR GO; GO:0048536; P:spleen development; ISS:UniProtKB.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR045114; Csn12-like.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR12732; PTHR12732; 1.
DR Pfam; PF01399; PCI; 1.
DR PROSITE; PS50250; PCI; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q5JVF3"
FT CHAIN 2..408
FT /note="PCI domain-containing protein 2"
FT /id="PRO_0000328622"
FT DOMAIN 210..400
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q5JVF3"
FT MOD_RES 45
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5JVF3"
SQ SEQUENCE 408 AA; 46814 MW; 2CDD4CD07F7F6FD9 CRC64;
MAHITINQYL QQVCEAIDTR DGASLAELVS FKHPHVANPR LQMASPEEKC QQVLEPPYDE
MFAAHLRCTY AVGNHDFIEA YKCQTVIVQS FLRAFQAHKE ENWALPVMYA VALDLRIFAN
NADQQLVKKG KSKVGDMLEK AAELLMGCFR VCASDTRAGI EDSKKRGMLF LVNQLFKIYF
KINKLHLCKP LIRAIDSSNL KDDYSTAQRV TYRYYVGRKA MFDSDFKQAE EYLSFAFEHC
HRSSQKNKRM VLIYLLPVKM LLGHMPTIEL LRKYHLMQFA EVTRAVSEGN LLLLNEALAA
HETFFIRCGI FLILEKLKII TYRNLFKKVN SLSSASSRYL LLKTHQLSLD AFLVALKFMQ
VEDVDIAEVQ CILANLIYMG HIKGYISHQH QKLVVSKQNP FPPLSTVC