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PCKA_KLULA
ID   PCKA_KLULA              Reviewed;         543 AA.
AC   O43112; Q6CYH0;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2004, sequence version 2.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Phosphoenolpyruvate carboxykinase (ATP);
DE            EC=4.1.1.49;
GN   Name=PCK1; OrderedLocusNames=KLLA0A00484g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=9717242;
RX   DOI=10.1002/(sici)1097-0061(199807)14:10<963::aid-yea282>3.0.co;2-x;
RA   Kitamoto H.K., Ohmomo S., Iimura Y.;
RT   "Isolation and nucleotide sequence of the gene encoding phosphoenolpyruvate
RT   carboxykinase from Kluyveromyces lactis.";
RL   Yeast 14:963-967(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + oxaloacetate = ADP + CO2 + phosphoenolpyruvate;
CC         Xref=Rhea:RHEA:18617, ChEBI:CHEBI:16452, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58702, ChEBI:CHEBI:456216;
CC         EC=4.1.1.49;
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC   -!- SIMILARITY: Belongs to the phosphoenolpyruvate carboxykinase (ATP)
CC       family. {ECO:0000305}.
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DR   EMBL; U88575; AAC27661.1; -; Genomic_DNA.
DR   EMBL; CR382121; CAH02607.1; -; Genomic_DNA.
DR   RefSeq; XP_451019.1; XM_451019.1.
DR   AlphaFoldDB; O43112; -.
DR   SMR; O43112; -.
DR   STRING; 28985.XP_451019.1; -.
DR   EnsemblFungi; CAH02607; CAH02607; KLLA0_A00484g.
DR   GeneID; 2896341; -.
DR   KEGG; kla:KLLA0_A00484g; -.
DR   eggNOG; ENOG502QQI5; Eukaryota.
DR   HOGENOM; CLU_018247_0_1_1; -.
DR   InParanoid; O43112; -.
DR   OMA; MRYAGEM; -.
DR   UniPathway; UPA00138; -.
DR   Proteomes; UP000000598; Chromosome A.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004612; F:phosphoenolpyruvate carboxykinase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   CDD; cd00484; PEPCK_ATP; 1.
DR   Gene3D; 3.40.449.10; -; 1.
DR   Gene3D; 3.90.228.20; -; 1.
DR   HAMAP; MF_00453; PEPCK_ATP; 1.
DR   InterPro; IPR001272; PEP_carboxykinase_ATP.
DR   InterPro; IPR013035; PEP_carboxykinase_C.
DR   InterPro; IPR008210; PEP_carboxykinase_N.
DR   InterPro; IPR015994; PEPCK_ATP_CS.
DR   PANTHER; PTHR30031; PTHR30031; 1.
DR   Pfam; PF01293; PEPCK_ATP; 1.
DR   PIRSF; PIRSF006294; PEP_crbxkin; 1.
DR   SUPFAM; SSF68923; SSF68923; 1.
DR   TIGRFAMs; TIGR00224; pckA; 1.
DR   PROSITE; PS00532; PEPCK_ATP; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Decarboxylase; Gluconeogenesis; Lyase; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..543
FT                   /note="Phosphoenolpyruvate carboxykinase (ATP)"
FT                   /id="PRO_0000203873"
FT   BINDING         244..251
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        236
FT                   /note="D -> G (in Ref. 1; AAC27661)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        255
FT                   /note="A -> G (in Ref. 1; AAC27661)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        500
FT                   /note="S -> I (in Ref. 1; AAC27661)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        509
FT                   /note="K -> N (in Ref. 1; AAC27661)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        520
FT                   /note="L -> W (in Ref. 1; AAC27661)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        523
FT                   /note="E -> K (in Ref. 1; AAC27661)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   543 AA;  60429 MW;  35CD60147227B2A4 CRC64;
     MSPTKTQNSA EENIRAELGL SAEVVTIRRN APAALLYEDA LKERDTAISN AGALIAYSGD
     KTGRSPRDKR IVEEETSKDN VWWGPVNKPC SERTWEINRE RAADYLRTRD HIYIVDAYAG
     WDPRYRIKVR VVCARAYHAL FMTNMLIRPS KEELENFGEP DFTVWNAGQF PANTHTSGMT
     SKTTVEINFK QMEMVILGTE YAGEMKKGIF TVMFYLMPVN HNVLTLHSSA NQGIQDNDVT
     LFFGLSGTGK TTLSADPHRL LIGDDEHCWS DHGVFNIEGG CYAKCLGLSA EKEPEIFNAI
     KFGSVLENII YDPNTREVDY EDSTITENTR CAYPIEYIPS AKIPCLADHH PKNIVLLTCD
     ASGVLPPVSK LTPDQVMYHF ISGYTSKMAG TEQGVTEPEA TFSSCFGQPF LSLHPMKYAT
     MLAEKMAEHN ANAWLINTGW TGSSYVAGGK RCPLKYTRAI LDAIHDGSLA KEEYEVLPIF
     NLQIPKAVGD KVPASLLNPS KNWAEGEAKY TSNVKSLANL FVENFKTYQD KATEQVLAAG
     PQL
 
 
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