ID   PCKA_NEUCR              Reviewed;         605 AA.
AC   Q7RVS9;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   19-MAR-2014, sequence version 2.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Phosphoenolpyruvate carboxykinase (ATP);
DE            EC=4.1.1.49;
DE   AltName: Full=Acetate utilization protein 6;
GN   Name=acu-6; Synonyms=pck1; ORFNames=NCU09873;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + oxaloacetate = ADP + CO2 + phosphoenolpyruvate;
CC         Xref=Rhea:RHEA:18617, ChEBI:CHEBI:16452, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58702, ChEBI:CHEBI:456216;
CC         EC=4.1.1.49;
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC   -!- SIMILARITY: Belongs to the phosphoenolpyruvate carboxykinase (ATP)
CC       family. {ECO:0000305}.
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DR   EMBL; CM002241; EAA30919.2; -; Genomic_DNA.
DR   RefSeq; XP_960155.2; XM_955062.3.
DR   AlphaFoldDB; Q7RVS9; -.
DR   SMR; Q7RVS9; -.
DR   STRING; 5141.EFNCRP00000009773; -.
DR   PRIDE; Q7RVS9; -.
DR   EnsemblFungi; EAA30919; EAA30919; NCU09873.
DR   GeneID; 3876302; -.
DR   KEGG; ncr:NCU09873; -.
DR   VEuPathDB; FungiDB:NCU09873; -.
DR   HOGENOM; CLU_018247_2_0_1; -.
DR   InParanoid; Q7RVS9; -.
DR   UniPathway; UPA00138; -.
DR   Proteomes; UP000001805; Chromosome 5, Linkage Group VI.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004612; F:phosphoenolpyruvate carboxykinase (ATP) activity; IBA:GO_Central.
DR   GO; GO:0006094; P:gluconeogenesis; IBA:GO_Central.
DR   CDD; cd00484; PEPCK_ATP; 1.
DR   Gene3D; 3.40.449.10; -; 1.
DR   Gene3D; 3.90.228.20; -; 1.
DR   HAMAP; MF_00453; PEPCK_ATP; 1.
DR   InterPro; IPR001272; PEP_carboxykinase_ATP.
DR   InterPro; IPR013035; PEP_carboxykinase_C.
DR   InterPro; IPR008210; PEP_carboxykinase_N.
DR   InterPro; IPR015994; PEPCK_ATP_CS.
DR   PANTHER; PTHR30031; PTHR30031; 1.
DR   Pfam; PF01293; PEPCK_ATP; 1.
DR   PIRSF; PIRSF006294; PEP_crbxkin; 1.
DR   SUPFAM; SSF68923; SSF68923; 1.
DR   TIGRFAMs; TIGR00224; pckA; 1.
DR   PROSITE; PS00532; PEPCK_ATP; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Decarboxylase; Gluconeogenesis; Lyase; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..605
FT                   /note="Phosphoenolpyruvate carboxykinase (ATP)"
FT                   /id="PRO_0000203874"
FT   REGION          27..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        27..55
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         307..314
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   605 AA;  67258 MW;  C262857357BC16C5 CRC64;
     MGDPVIRTAS PYTNPIIKCP RLQRLSSGPS SSFINNNNSN NNNNKSSNMF NHDHVNKTNL
     HPGGVKPHVE HTELEEELHQ KAHIDYDRVA IIANPSVASL YEDALVYETG TAITSSGALT
     AYSGKKTGRS PSDKRIVKEP SSENDIWWGP VNKPMSPEVW KINRERAVDY LNTRNRIYVV
     DGYAGWDEKY RIRVRVVCAR AYHALFMRNM LIRPPREELE HFHPDYTIYN AGSFPANRYT
     EGMSSSTSVA INFAEKEMVI LGTEYAGEMK KGIFTVMFYE GPVKHNILTL HSSANEGKDG
     DVTLFFGLSG TGKTTLSADP NRRLIGDDEH CWSDRGVFNI EGGCYAKTIG LSAEKEPDIF
     NAIRYGSVLE NVVFNPETRE VDYGDATLTE NTRCAYPIEY IPNAKIPCLS PNHPKNIILL
     TCDARGVLPP ISKLDSAQTM FHFISGYTSK MAGTEDGILE PQATFSSCFA QPFLALHPMR
     YAKMLAEKIE NHNANAWLLN TGWVGAGFAQ GGKRCPLKYT RAILDAIHSG ELANVEYENY
     EVFNLQVPKS CPGVPSELLN PKTAWTAGAN SFDTEVKKLG GLFLENFKKY ESEATEDVIK
     AGPVV