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PCKA_TRYCR
ID   PCKA_TRYCR              Reviewed;         472 AA.
AC   P51058;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Phosphoenolpyruvate carboxykinase (ATP), glycosomal;
DE            EC=4.1.1.49;
GN   Name=PEPCK;
OS   Trypanosoma cruzi.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=5693;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8294043; DOI=10.1016/0378-1119(93)90449-d;
RA   Linss J., Goldenberg S., Urbina J.A., Amzel L.M.;
RT   "Cloning and characterization of the gene encoding ATP-dependent phospho-
RT   enol-pyruvate carboxykinase in Trypanosoma cruzi: comparison of primary and
RT   predicted secondary structure with host GTP-dependent enzyme.";
RL   Gene 136:69-77(1993).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + oxaloacetate = ADP + CO2 + phosphoenolpyruvate;
CC         Xref=Rhea:RHEA:18617, ChEBI:CHEBI:16452, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58702, ChEBI:CHEBI:456216;
CC         EC=4.1.1.49;
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Glycosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the phosphoenolpyruvate carboxykinase (ATP)
CC       family. {ECO:0000305}.
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DR   EMBL; M91163; AAA50780.1; -; mRNA.
DR   PDB; 1II2; X-ray; 2.00 A; A/B=2-457.
DR   PDBsum; 1II2; -.
DR   AlphaFoldDB; P51058; -.
DR   SMR; P51058; -.
DR   VEuPathDB; TriTrypDB:BCY84_02917; -.
DR   VEuPathDB; TriTrypDB:C3747_111g98; -.
DR   VEuPathDB; TriTrypDB:C4B63_9g285; -.
DR   VEuPathDB; TriTrypDB:Tc_MARK_9661; -.
DR   VEuPathDB; TriTrypDB:TcBrA4_0071790; -.
DR   VEuPathDB; TriTrypDB:TcCL_ESM11520; -.
DR   VEuPathDB; TriTrypDB:TcCLB.507547.90; -.
DR   VEuPathDB; TriTrypDB:TcCLB.508441.20; -.
DR   VEuPathDB; TriTrypDB:TCDM_05454; -.
DR   VEuPathDB; TriTrypDB:TcG_04606; -.
DR   VEuPathDB; TriTrypDB:TCSYLVIO_007781; -.
DR   VEuPathDB; TriTrypDB:TcYC6_0076530; -.
DR   BRENDA; 4.1.1.49; 6524.
DR   SABIO-RK; P51058; -.
DR   UniPathway; UPA00138; -.
DR   EvolutionaryTrace; P51058; -.
DR   GO; GO:0020015; C:glycosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004612; F:phosphoenolpyruvate carboxykinase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.449.10; -; 1.
DR   Gene3D; 3.90.228.20; -; 1.
DR   HAMAP; MF_00453; PEPCK_ATP; 1.
DR   InterPro; IPR001272; PEP_carboxykinase_ATP.
DR   InterPro; IPR013035; PEP_carboxykinase_C.
DR   InterPro; IPR008210; PEP_carboxykinase_N.
DR   InterPro; IPR015994; PEPCK_ATP_CS.
DR   PANTHER; PTHR30031; PTHR30031; 1.
DR   Pfam; PF01293; PEPCK_ATP; 1.
DR   PIRSF; PIRSF006294; PEP_crbxkin; 1.
DR   SUPFAM; SSF68923; SSF68923; 1.
DR   PROSITE; PS00532; PEPCK_ATP; 1.
PE   1: Evidence at protein level;
KW   3D-structure; ATP-binding; Decarboxylase; Gluconeogenesis; Glycosome;
KW   Lyase; Nucleotide-binding; Peroxisome.
FT   CHAIN           1..472
FT                   /note="Phosphoenolpyruvate carboxykinase (ATP), glycosomal"
FT                   /id="PRO_0000203868"
FT   BINDING         221..228
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   STRAND          4..8
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   HELIX           11..21
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   STRAND          33..35
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   STRAND          41..43
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   HELIX           45..47
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   STRAND          48..51
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   HELIX           54..57
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   TURN            63..65
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   HELIX           71..86
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   STRAND          88..98
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   TURN            102..104
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   STRAND          106..114
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   HELIX           115..124
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   HELIX           130..134
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   STRAND          140..146
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   STRAND          163..167
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   TURN            168..171
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   STRAND          172..177
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   HELIX           182..198
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   STRAND          202..210
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   STRAND          216..220
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   HELIX           227..231
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   STRAND          236..242
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   STRAND          244..246
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   STRAND          251..254
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   STRAND          256..261
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   TURN            267..269
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   HELIX           271..275
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   STRAND          282..285
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   TURN            290..292
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   STRAND          307..311
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   HELIX           312..314
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   STRAND          327..334
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   STRAND          343..347
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   HELIX           349..358
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   STRAND          360..363
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   STRAND          365..368
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   STRAND          376..379
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   HELIX           381..383
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   HELIX           385..387
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   HELIX           392..406
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   STRAND          409..414
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   STRAND          416..420
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   HELIX           422..424
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   HELIX           431..442
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   STRAND          443..445
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   HELIX           446..448
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   STRAND          451..454
FT                   /evidence="ECO:0007829|PDB:1II2"
FT   TURN            455..457
FT                   /evidence="ECO:0007829|PDB:1II2"
SQ   SEQUENCE   472 AA;  52585 MW;  ECD918DB3882CFE0 CRC64;
     MPPTIHRNLL SPELVQWALK IEKDSRLTAR GALAVMSYAK TGRSPLDKRI VDTDDVRENV
     DWGKVNMKLS EESFARVRKI AKEFLDTREH LFVVDCFAGH DERYRLKVRV FTTRPYHALF
     MRDMLIVPTP EELATFGEPD YVIYNAGECK ADPSIPGLTS TTCVALNFKT REQVILGTEY
     AGEMKKGILT VMFELMPQMN HLCMHASANV GKQGDVTVFF GLSGTGKTTL SADPHRNLIG
     DDEHVWTDRG VFNIEGGCYA KAIGLNPKTE KDIYDAVRFG AVAENCVLDK RTGEIDFYDE
     SICKNTRVAY PLSHIEGALS KAIAGHPKNV IFLTNDAFGV MPPVARLTSA QAMFWFVMGY
     TANVPGVEAG GTRTARPIFS SCFGGPFLVR HATFYGEQLA EKMQKHNSRV WLLNTGYAGG
     RADRGAKRMP LRVTRAIIDA IHDGTLDRTE YEEYPGWACT SRSTSPKCRS IC
 
 
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