ID   PCKG_FASHE              Reviewed;          10 AA.
AC   P80525;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   22-APR-2020, entry version 49.
DE   RecName: Full=Putative phosphoenolpyruvate carboxykinase [GTP];
DE            Short=PEPCK;
DE            EC=4.1.1.32;
DE   AltName: Full=Newly excysted juvenile protein 1;
DE   Flags: Fragment;
OS   Fasciola hepatica (Liver fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Plagiorchiida; Echinostomata; Echinostomatoidea; Fasciolidae;
OC   Fasciola.
OX   NCBI_TaxID=6192;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=7639732; DOI=10.1006/bbrc.1995.2112;
RA   Tkalcevic J., Ashman K., Meeusen E.;
RT   "Fasciola hepatica: rapid identification of newly excysted juvenile
RT   proteins.";
RL   Biochem. Biophys. Res. Commun. 213:169-174(1995).
CC   -!- FUNCTION: Catalyzes the conversion of oxaloacetate (OAA) to
CC       phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic
CC       pathway that produces glucose from lactate and other precursors derived
CC       from the citric acid cycle. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + oxaloacetate = CO2 + GDP + phosphoenolpyruvate;
CC         Xref=Rhea:RHEA:10388, ChEBI:CHEBI:16452, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:37565, ChEBI:CHEBI:58189, ChEBI:CHEBI:58702; EC=4.1.1.32;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU10113};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC       Note=Binds 1 Mn(2+) ion per subunit. {ECO:0000250};
CC   -!- SUBUNIT: Monomer.
CC   -!- SIMILARITY: Belongs to the phosphoenolpyruvate carboxykinase [GTP]
CC       family. {ECO:0000305}.
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DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004613; F:phosphoenolpyruvate carboxykinase (GTP) activity; IEA:UniProtKB-EC.
PE   1: Evidence at protein level;
KW   Decarboxylase; Direct protein sequencing; GTP-binding; Lyase; Manganese;
KW   Metal-binding; Nucleotide-binding.
FT   CHAIN           1..>10
FT                   /note="Putative phosphoenolpyruvate carboxykinase [GTP]"
FT                   /id="PRO_0000103634"
FT   NON_TER         10
SQ   SEQUENCE   10 AA;  1069 MW;  8393A6187AA9C87A CRC64;
     YPDGFDGEAV