ASPG2_DROME
ID ASPG2_DROME Reviewed; 397 AA.
AC Q9W2C3;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=L-asparaginase-like protein CG4372;
DE Flags: Precursor;
GN ORFNames=CG4372;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000312|EMBL:AAF46769.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000312|EMBL:AAF46769.2}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- SIMILARITY: Belongs to the Ntn-hydrolase family. {ECO:0000255}.
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DR EMBL; AE013599; AAF46769.2; -; Genomic_DNA.
DR RefSeq; NP_611615.1; NM_137771.1.
DR AlphaFoldDB; Q9W2C3; -.
DR SMR; Q9W2C3; -.
DR STRING; 7227.FBpp0071652; -.
DR MEROPS; T02.A04; -.
DR PaxDb; Q9W2C3; -.
DR PRIDE; Q9W2C3; -.
DR EnsemblMetazoa; FBtr0071738; FBpp0071652; FBgn0034665.
DR GeneID; 37490; -.
DR KEGG; dme:Dmel_CG4372; -.
DR UCSC; CG4372-RA; d. melanogaster.
DR FlyBase; FBgn0034665; CG4372.
DR VEuPathDB; VectorBase:FBgn0034665; -.
DR eggNOG; KOG1593; Eukaryota.
DR GeneTree; ENSGT00950000183045; -.
DR HOGENOM; CLU_021603_0_0_1; -.
DR InParanoid; Q9W2C3; -.
DR OMA; QAVIQGC; -.
DR OrthoDB; 1487354at2759; -.
DR PhylomeDB; Q9W2C3; -.
DR BioGRID-ORCS; 37490; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 37490; -.
DR PRO; PR:Q9W2C3; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0034665; Expressed in seminal fluid secreting gland.
DR Genevisible; Q9W2C3; DM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005764; C:lysosome; IBA:GO_Central.
DR GO; GO:0003948; F:N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity; IBA:GO_Central.
DR GO; GO:0006517; P:protein deglycosylation; IBA:GO_Central.
DR InterPro; IPR029055; Ntn_hydrolases_N.
DR InterPro; IPR000246; Peptidase_T2.
DR PANTHER; PTHR10188; PTHR10188; 1.
DR Pfam; PF01112; Asparaginase_2; 1.
DR SUPFAM; SSF56235; SSF56235; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Reference proteome; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..397
FT /note="L-asparaginase-like protein CG4372"
FT /id="PRO_0000384143"
FT DISULFID 90..95
FT /evidence="ECO:0000250|UniProtKB:P20933"
FT DISULFID 189..205
FT /evidence="ECO:0000250|UniProtKB:P20933"
FT DISULFID 344..371
FT /evidence="ECO:0000250"
SQ SEQUENCE 397 AA; 43682 MW; 52C94CE928C99C46 CRC64;
MLAQSCCLRL LILLLLFTTI GSVPKKSLKY FTNRKLRERR IKLFGTKKTE IQSLLISTWN
YTDANLQAWS VLQQGPRRTR QAVIQGCMAC QNQRCGRLLT GRSSPDTEGA LTLEAAIMDG
ESLEYGAVAG MNGVRNAILV ADAVLKYTKH SVLVGKSATK FARSLGYKEE YLTDARTRNV
LKKWRSNGCQ PNFWRDVHPS PAENCGPYSP LPEHMHQHPM HQEYAIIQGQ HDQLAFLALD
AEGKFHVASQ SSGAQFRIPG RVGDSAVPGA GIYADNEVGG AVASGDGDVL MRHLPAFLAV
EAMRAGKEPD KAAELVVQRL LRHNTEFNGA VVVVNRRGIY AAACAGLDEF HFVVSGGKEY
LSMARVERVK CLERENEVID GGPKGLFPTI PEKHKVP
