ID   ASPG2_DROPS             Reviewed;         457 AA.
AC   Q28XQ5;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 2.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=L-asparaginase-like protein GA18140;
DE   Flags: Precursor;
GN   ORFNames=GA18140;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1] {ECO:0000312|EMBL:EAL26261.2}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- SIMILARITY: Belongs to the Ntn-hydrolase family. {ECO:0000255}.
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DR   EMBL; CM000071; EAL26261.2; -; Genomic_DNA.
DR   RefSeq; XP_001361682.2; XM_001361645.3.
DR   AlphaFoldDB; Q28XQ5; -.
DR   SMR; Q28XQ5; -.
DR   STRING; 7237.FBpp0276041; -.
DR   MEROPS; T02.001; -.
DR   EnsemblMetazoa; FBtr0277603; FBpp0276041; FBgn0078148.
DR   GeneID; 4805250; -.
DR   KEGG; dpo:Dpse_GA18140; -.
DR   eggNOG; KOG1593; Eukaryota.
DR   HOGENOM; CLU_021603_0_0_1; -.
DR   InParanoid; Q28XQ5; -.
DR   OMA; QAVIQGC; -.
DR   Proteomes; UP000001819; Chromosome 3.
DR   Bgee; FBgn0078148; Expressed in male reproductive system and 1 other tissue.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   InterPro; IPR029055; Ntn_hydrolases_N.
DR   InterPro; IPR000246; Peptidase_T2.
DR   PANTHER; PTHR10188; PTHR10188; 1.
DR   Pfam; PF01112; Asparaginase_2; 1.
DR   SUPFAM; SSF56235; SSF56235; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Reference proteome; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..457
FT                   /note="L-asparaginase-like protein GA18140"
FT                   /id="PRO_0000384145"
FT   DISULFID        72..78
FT                   /evidence="ECO:0000250|UniProtKB:P20933"
FT   DISULFID        172..188
FT                   /evidence="ECO:0000250|UniProtKB:P20933"
FT   DISULFID        327..354
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   457 AA;  49694 MW;  83020CE4BA93509F CRC64;
     MRYLCRAQLL SLLLLPLLKA RLSVPAHPIP KIFLPLMIST WNYTDANREA WTVLRQGPRR
     TRQAVIQGCL HCQNSNSCGR LLGGHSAPDS SGGITLEAAL IDGANMDYGA VAGMAGIRNA
     IGVAHDVLRY TNHSLLVGEA AARFAEAMGH KKEVHSLSTT LDVLLPWLLG KCQPNFWRNV
     RPLANDSCGT FSPLPQEQHQ REMRQEYPIE PGHHDQVGFL ALDTEGHLHA ASLSSGARFR
     IPGRVGDAAV PGAGIYADNQ VGGALATGDG DVLMRFLPAL LAVEALRAGQ SPASAAEAVM
     RRLLRHHTEF NGGLVVVSRG GVYSAACAGL DEFQFVVSGE SSGRSMRRVE GIKCLDRHEV
     VTGGPRGNFY VVPKKIWAAG GEDVLVQRVE KITLNEGVDS REFEEEYVED KAAEIDVDEG
     EKAEEVRSLL DESPGDLLLH QLGLAPPFPF RFPFIYF