PCL9_YEAST
ID PCL9_YEAST Reviewed; 304 AA.
AC Q12477; D6VRH3;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=PHO85 cyclin-9;
GN Name=PCL9; OrderedLocusNames=YDL179W; ORFNames=D1408;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP INTERACTION WITH PHO85, AND INDUCTION.
RX PubMed=9032248; DOI=10.1128/mcb.17.3.1212;
RA Measday V., Moore L., Retnakaran R., Lee J., Donoviel M., Neiman A.M.,
RA Andrews B.J.;
RT "A family of cyclin-like proteins that interact with the Pho85 cyclin-
RT dependent kinase.";
RL Mol. Cell. Biol. 17:1212-1223(1997).
RN [5]
RP FUNCTION, INTERACTION WITH PHO85, AND INDUCTION.
RX PubMed=9529390; DOI=10.1091/mbc.9.4.945;
RA Aerne B.L., Johnson A.L., Toyn J.H., Johnston L.H.;
RT "Swi5 controls a novel wave of cyclin synthesis in late mitosis.";
RL Mol. Biol. Cell 9:945-956(1998).
RN [6]
RP FUNCTION, AND INTERACTION WITH PHO85.
RX PubMed=9593297; DOI=10.1046/j.1365-2958.1998.00773.x;
RA Tennyson C.N., Lee J., Andrews B.J.;
RT "A role for the Pcl9-Pho85 cyclin-cdk complex at the M/G1 boundary in
RT Saccharomyces cerevisiae.";
RL Mol. Microbiol. 28:69-79(1998).
CC -!- FUNCTION: M/G1-specific cyclin partner of the cyclin-dependent kinase
CC (CDK) PHO85. May have a role in bud site selection in G1 phase.
CC {ECO:0000269|PubMed:9529390, ECO:0000269|PubMed:9593297}.
CC -!- SUBUNIT: Forms a cyclin-CDK complex with PHO85.
CC -!- INTERACTION:
CC Q12477; P17157: PHO85; NbExp=4; IntAct=EBI-38090, EBI-13327;
CC -!- INDUCTION: By transcription factor SWI5 in a cell cycle-regulated
CC manner. Peaks in late M, early G1 phase (at protein level).
CC {ECO:0000269|PubMed:9032248, ECO:0000269|PubMed:9529390}.
CC -!- SIMILARITY: Belongs to the cyclin family. PCL1,2 subfamily.
CC {ECO:0000305}.
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DR EMBL; Z67750; CAA91566.1; -; Genomic_DNA.
DR EMBL; Z74227; CAA98753.1; -; Genomic_DNA.
DR EMBL; AY557655; AAS55981.1; -; Genomic_DNA.
DR EMBL; BK006938; DAA11683.1; -; Genomic_DNA.
DR PIR; S61033; S61033.
DR RefSeq; NP_010102.1; NM_001180239.1.
DR AlphaFoldDB; Q12477; -.
DR SMR; Q12477; -.
DR BioGRID; 31887; 65.
DR ComplexPortal; CPX-1697; PCL9-PHO85 kinase complex.
DR DIP; DIP-1510N; -.
DR IntAct; Q12477; 15.
DR MINT; Q12477; -.
DR STRING; 4932.YDL179W; -.
DR PaxDb; Q12477; -.
DR EnsemblFungi; YDL179W_mRNA; YDL179W; YDL179W.
DR GeneID; 851375; -.
DR KEGG; sce:YDL179W; -.
DR SGD; S000002338; PCL9.
DR VEuPathDB; FungiDB:YDL179W; -.
DR eggNOG; KOG1674; Eukaryota.
DR GeneTree; ENSGT00390000000862; -.
DR HOGENOM; CLU_018149_0_0_1; -.
DR InParanoid; Q12477; -.
DR OMA; HNVIACD; -.
DR BioCyc; YEAST:G3O-29566-MON; -.
DR PRO; PR:Q12477; -.
DR Proteomes; UP000002311; Chromosome IV.
DR RNAct; Q12477; protein.
DR GO; GO:0005935; C:cellular bud neck; IDA:SGD.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IPI:SGD.
DR GO; GO:0000131; C:incipient cellular bud site; IDA:SGD.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IMP:SGD.
DR GO; GO:0019901; F:protein kinase binding; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0032878; P:regulation of establishment or maintenance of cell polarity; IGI:SGD.
DR GO; GO:0000083; P:regulation of transcription involved in G1/S transition of mitotic cell cycle; IDA:ComplexPortal.
DR CDD; cd00043; CYCLIN; 1.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR006671; Cyclin_N.
DR InterPro; IPR013922; Cyclin_PHO80-like.
DR InterPro; IPR012104; PHO85_cyclin_1/2/9.
DR PANTHER; PTHR15615; PTHR15615; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR PIRSF; PIRSF016511; Cyclin_Pcl; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SUPFAM; SSF47954; SSF47954; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Cyclin; Reference proteome.
FT CHAIN 1..304
FT /note="PHO85 cyclin-9"
FT /id="PRO_0000271788"
FT DOMAIN 19..146
FT /note="Cyclin N-terminal"
SQ SEQUENCE 304 AA; 34798 MW; 183820067EC00D23 CRC64;
MISDYDALLQ FNKKPVSQEM IQFLATSTAS IIKIRENNNP IQGCRPPDLS IFIKNVVIQS
NVQTPTLMAT SVYLNKLKSV IPKNVYGINT TRHRIFLGCL ILAAKTLNDS SPWNKHWTTY
TEGLLRIREV NTIERELLEY LNWDVRITTP DLIDSLSYFL GPIKEQLFLQ RRQEMLLFNA
PSPGQLKEYI NHRRPVSHSR TSSAISVPSL TSMATVSTTD SRSSLLAKYQ PSLPLVESDN
FNKKNHVPLR NNNDICNNFR AEENIHSVNH IDVTMGSSPV MSHKPTIHQR LNFTRRGWSS
FFKQ
