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PCLO_CHICK
ID   PCLO_CHICK              Reviewed;        5120 AA.
AC   Q9PU36;
DT   19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Protein piccolo {ECO:0000305};
DE   AltName: Full=Aczonin {ECO:0000303|PubMed:10508862};
DE   Flags: Fragment;
GN   Name=PCLO; Synonyms=ACZ {ECO:0000303|PubMed:10508862};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000312|EMBL:CAB60725.1};
RN   [1] {ECO:0000312|EMBL:CAB60725.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=10508862; DOI=10.1083/jcb.147.1.151;
RA   Wang X., Kibschull M., Laue M.M., Lichte B., Petrasch-Parwez E.,
RA   Kilimann M.W.;
RT   "Aczonin, a 550-kd putative scaffolding protein of presynaptic active
RT   zones, shares homology regions with rim and bassoon and binds profilin.";
RL   J. Cell Biol. 147:151-162(1999).
CC   -!- FUNCTION: May act as a scaffolding protein involved in the organization
CC       of synaptic active zones and in synaptic vesicle trafficking.
CC       {ECO:0000250|UniProtKB:Q9QYX7}.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU00041};
CC       Note=Binds 3 Ca(2+) ions per C2 domain. {ECO:0000255|PROSITE-
CC       ProRule:PRU00041};
CC   -!- SUBUNIT: Interacts with RABAC1/PRA1 and profilin. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Presynaptic active zone
CC       {ECO:0000250|UniProtKB:Q9QYX7}. Note=Colocalizes with BSN in developing
CC       axons. {ECO:0000250|UniProtKB:Q9JKS6}.
CC   -!- DOMAIN: C2 domain 1 is involved in binding calcium and phospholipids.
CC       Calcium binds with low affinity but with high specificity and induces a
CC       large conformational change. {ECO:0000250|UniProtKB:Q9JKS6}.
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DR   EMBL; Y19187; CAB60725.1; -; mRNA.
DR   SMR; Q9PU36; -.
DR   STRING; 9031.ENSGALP00000039055; -.
DR   PaxDb; Q9PU36; -.
DR   PRIDE; Q9PU36; -.
DR   VEuPathDB; HostDB:geneid_395319; -.
DR   eggNOG; KOG2060; Eukaryota.
DR   InParanoid; Q9PU36; -.
DR   OrthoDB; 15051at2759; -.
DR   PhylomeDB; Q9PU36; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0030424; C:axon; IBA:GO_Central.
DR   GO; GO:0048788; C:cytoskeleton of presynaptic active zone; IBA:GO_Central.
DR   GO; GO:0098982; C:GABA-ergic synapse; IBA:GO_Central.
DR   GO; GO:0098978; C:glutamatergic synapse; IBA:GO_Central.
DR   GO; GO:0045202; C:synapse; ISS:UniProtKB.
DR   GO; GO:0005509; F:calcium ion binding; ISS:UniProtKB.
DR   GO; GO:0005544; F:calcium-dependent phospholipid binding; ISS:UniProtKB.
DR   GO; GO:0005522; F:profilin binding; ISS:UniProtKB.
DR   GO; GO:0098882; F:structural constituent of presynaptic active zone; IBA:GO_Central.
DR   GO; GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.
DR   GO; GO:1904071; P:presynaptic active zone assembly; IBA:GO_Central.
DR   GO; GO:0035418; P:protein localization to synapse; IBA:GO_Central.
DR   CDD; cd15774; FYVE1_PCLO; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 2.60.40.150; -; 2.
DR   Gene3D; 3.30.40.10; -; 2.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR042720; PCLO_FYVE1.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR030629; Piccolo.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR008899; Znf_piccolo.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR14113:SF6; PTHR14113:SF6; 2.
DR   Pfam; PF00168; C2; 2.
DR   Pfam; PF00595; PDZ; 1.
DR   Pfam; PF05715; zf-piccolo; 2.
DR   SMART; SM00239; C2; 2.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF49562; SSF49562; 2.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   SUPFAM; SSF57903; SSF57903; 2.
DR   PROSITE; PS50004; C2; 2.
DR   PROSITE; PS50106; PDZ; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Calcium/phospholipid-binding; Cell projection; Metal-binding;
KW   Reference proteome; Repeat; Synapse; Zinc; Zinc-finger.
FT   CHAIN           <1..5120
FT                   /note="Protein piccolo"
FT                   /id="PRO_0000058249"
FT   DOMAIN          4414..4493
FT                   /note="PDZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00143,
FT                   ECO:0000305"
FT   DOMAIN          4611..4742
FT                   /note="C2 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   DOMAIN          4985..5110
FT                   /note="C2 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   ZN_FING         368..392
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         836..859
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255"
FT   REGION          1..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          94..366
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          258..357
FT                   /note="10 X 10 AA tandem approximate repeats of P-A-K-P-Q-
FT                   P-Q-Q-P-X"
FT   REGION          428..706
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          720..836
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          897..1022
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1117..1331
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1357..1786
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1992..2012
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2272..2301
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2315..2349
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2472..2492
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3322..3414
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3470..3536
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3566..3654
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4191..4265
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4306..4328
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4365..4396
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4560..4610
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4750..4826
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4903..4977
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        94..119
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        120..162
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        184..258
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        265..284
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        298..336
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        345..366
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        449..483
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        492..544
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        557..573
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        596..618
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        623..640
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        720..738
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        739..764
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        801..826
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        909..923
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        924..942
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1117..1218
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1228..1267
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1268..1296
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1298..1312
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1313..1331
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1357..1372
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1407..1481
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1491..1518
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1529..1569
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1586..1601
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1633..1656
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1702..1743
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1758..1772
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1993..2012
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2286..2301
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2322..2349
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3322..3382
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3392..3414
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3473..3498
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3590..3630
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3639..3654
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4192..4234
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4250..4265
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4365..4389
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4560..4594
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4754..4771
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4789..4826
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4915..4951
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         4642
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   BINDING         4642
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   BINDING         4648
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   BINDING         4712
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   BINDING         4712
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   BINDING         4714
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   BINDING         4714
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   BINDING         4714
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   BINDING         4717
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   BINDING         4720
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   BINDING         4720
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   NON_TER         1
FT                   /evidence="ECO:0000312|EMBL:CAB60725.1"
SQ   SEQUENCE   5120 AA;  560764 MW;  A658D9891B65B412 CRC64;
     LDTTHHPRQP GKPPDPGPGL SKSRTVDVLK TEQRAPGRSP SSISLRESKS RTDFKEDQKP
     SMMPSFFSEA NPLSAVTSVV NKFSPFDLIS DSDAAHEEAG RKQKVTQKEQ GKPEEQRGLA
     KHPSQQQSPK LVQQQGPVKP TPQQTESSKP VPQQQQPGEP KQGQKPGPSH PGDSKAEQVK
     QPPQPRGPQK SQLQQSEPTK PGQQQTSAKT SAGPTKPLPQ QPDSAKTSSQ APPPTKPSLQ
     QSGSVKQPSQ QPARQGGPVK PSAQQAGPPK QQPGSEKPTA QQTGPAKQPP QPGPGKTPLQ
     QTGPVKQVPP QAGPTKPSSQ TAGAAKSLAQ QPGLTKPPGQ QPGPEKPLQQ KQASTTQPVE
     STPKKTFCPL CTTTELLLHT PEKANYNTCT QCHTVVCSLC GFNPNPHITE IKEWLCLNCQ
     MQRALGGDLA SGHGPGPQLP PPKQKTPTPA STAKPSPQLQ PGQKKDASPK PDPSQQADSK
     KPVPQKKQPS MPGSPPVKSK QTHAEPSDTG QQIDSTPKSD QVKPTQAEEK QNQPSIQKPT
     MDTVPTSAAP GVKQDLADPQ SPSTQQKVTD SPMPETTKPP ADTHPAGDKP DSKPLPQVSR
     QKSDPKLASQ SGAKSDAKTQ KPSEPAPVKD DPKKLQTKPA PKPDTKPAPK GPQAGTGPRP
     TSAQPAPQPQ QPQKTPEQSR RFSLNLGGIT DAPKPQPTTP QETVTGKLFG FGASIFSQAS
     SLISTAGQPG SQTSGPAPPA TKQPQPPSQP PASQAPPKEA AQAQPPPKAA PTKKETKPLA
     SEKLGPMASD STLTTKGSDL EKKPSLAKDS KHQTAEAKKP AELSEQEKAS QPKVSCPLCK
     TGLNIGSKDP PNFNTCTECK KVVCNLCGFN PMPHIVEVQE WLCLNCQTQR AMSGQLGDMG
     KVPLPKLGPS QPVSKPPATP QKQPVPAVSH SPQKSSTPPT PAATKPKEEP SVPKEVPKLQ
     QGKLEKTLSA DKIQQGIQKE DAKSKQGKLF KTPSADKIQR VSQKEDSRLQ QTKLTKTPSS
     DKILHGVQKE DIKFQEAKLA KIPSADKILH RLQKEDPKLQ QMKMAKALSA DKIQPEAQKE
     DVQLQEVRLS KAVSADKIQH GIQKDLNLQH VKIEKTSSVE KIQEAQKESK LQQDKLPKTL
     SEDKIPATVS SDHKKLLSKS EEDKKPELLE KSTPHPKDKK EQITAETTGH ITEQKVEVEA
     PCDKLHEKKQ EDVKKEDLTT GIPQMVSKPE KAEEEKTPVP VSRLPRSDHV EAVREKIEKE
     DDKSDTSSSQ QQKSPQGLSD TGYSSDGISS SLGEIPSHIP SDEKDLPREP SQKDTISQES
     PPSPSDLAKL ESTVLSILEA QASTLTDEKS VKRKELYETY SEQTKDQHKT KPLPVTPESY
     SSDEEDLEAI QEGERTIAAD SKGGASSQTD YKEEDGGNDT PARRQRYDSV EDSSESENSP
     VPRRKRRASV GSSSSDEYKR DDSQGSGDEE DFIRKQIIEM SADEDASGSE DDEFIRNQLK
     EISVTESQKK EEVKSKAKGT VGKHRRMARK SSAGYDEDAG RRHSWHDDDD ETFDESPEPK
     YRETKSQDGE ELAISGGGGL RRFKTIELNS TITSKYSETP EQQKGILYFD EEPELEMESL
     TDSPEDRSRG EGSSSLHASS FTPGTSPTSV SSLDEDSDSS PSHKKLGGES KQQRKARHRS
     HGPLLPTIED SSEEEELREE EELLKEQEKQ RELEQQQRKS SSKKSKKDKD ELRAQRRRER
     PKTPPSNLSP IEDASPTEEL RQAAEMEELH RSSCSEYSPS IESDPEGFEI SPEKIIEVQK
     VYKLPTAVSL YSPTDEKLIG ALKEESGQKT LKSAEEVYEE MIHKTHKSKS FQIASEKDEV
     FEKESLYGGM LIEDYIYESL IEDTYNGTVD TNLAMRQDES NEYIQQRGKE KKIRASEQIY
     DEPQKITDLQ EDYYSVEPLC SIVPQEDIVS SSYIIPESHE IVVLDSTVTS TTEEKQLLDA
     EAAYEELMKK QRMQLTPGSS PTQPTSDLAP TSDMKVSSIG EIADSTSLTS STTSAISDVS
     SLSSIALSIP DVKITQHFTA EEIEDEYLTD YAREIQEIIS HETSMLTYSE VSEGAASILP
     SDTASLTSST SSVCTTDSSS PIDSATTGYV DTSDAVSKLV DSEDIIAQVP FTSTEEYSEV
     SMPYESVAGA TTKPAIASDM DTVHQAAVCL PETAPSVFTT TVIKPKQYAS DTITYDISTA
     EKDAARKMKS TVETGIIKIH HEDSHKELSL DMTRINLTGA TSEQPPLCVA SVSVKEPASE
     TPAVPTPRVV SKTSTVSMPS SAPALTSKVF SLFRSSSLDS PAQPSPPSPP PPPPPPPPPL
     PPPILPKPAI YPKKKSQIQA PMATAPTAVP LVTSVATLES AAVLKNHVVP VTKTYTPTPP
     PVPPKPSSIP AGLVFSHRPT EVTKPPIAPK PAVPPLPIAV HKPAETQPKP IGLSLTSSMT
     LNLVSSAEYK IASPTSPLSP HSNKSSPRLT KPSQETYVVI TLPSEPGTPT EAITSQAVTS
     WPLEAPSKEQ IPQPMQPIFT SSMKAVEIQS MADQSMYITG ALQTIPITTQ STFEKVPSSK
     SEAVTTEVAK TTASVVKRPV PSVGLGSVTI TIPPEPIYIS DQPRYRENGR FHPLGDVIDL
     RTLTKVDIEM RDSCMDLSAV SMDARRQMPT SDTSGRPVST VQPAIINLST ACVADPSLSI
     VTETVAVMTC TATVSYSAST DSLVDLGHAM TTPLQLTTSK HFEPAYRVTS SQPFPVSRDE
     VPINLSLGTS AHAVTWAATK PVTVPPVSVT NGWTDLSTSQ EPMEIGAVDL STTKSHRTVV
     TMDETTSGII TTVIEDDEKP VDLTAGRRAV CCDMVYKLPF GRSCTAQQPP TTLPEDRFGY
     RDDHYQYDRS GSYGYRGMGG MKPSMSDTNL SEAGLFAYKS KNSFDYQVGA TDAAVDLTSG
     RVTSGEVMDY SSKTTGPYPE TRQVISGIGI STPQYSQARM VSSLSSPFGA GSVLRSSNGV
     VYSSVATPIP STFAITTQPG SIFSTTVRDL PTLQTIDSVP SLSTLQQNQP LPRSYSFLTT
     MAAEKDASTT LDIETGLPPL TLESIATEPT NLIPATASEV YTDVIEDEVA LIIAPEEGKQ
     QQLDLERELL ELEKIKQQRF AEELEWERQE IQRFREQEKF MVQKKLEELQ SMKHHLLFQQ
     EEERQAQYMM RQETLAQQQL QLEQFQQLQQ QLHQQLEEQK IRQIYQYGYD PSGTGSPQTT
     TDQALLEGQY ATAENGQFWP TDDATTTASG VLGIEISQSQ TWYTVQSDGI TQYIPRSGIL
     SSVSEMSLKD IDVREEKQLK KRSSMPKLRG PYEELEESLE EEPRCYKKIV DSGVQTDDED
     GADRGYTNRR RRTKKSVDTS VQTDDEDQDE WDLSSRSGRK PRVGKYSEST TEADKAKQFS
     KVSSIAVQTV AEISVQTEPV GTIRTPSIRA RLDAKVEIIK HISAPEKTYK GESLGCQTET
     ESDTQSPQYL SASSPQKDKK RPTPLEIGYS SHLRPDSTLQ VVPSPPKSPK VLYSPISPVS
     PSKVIESAFV PYEKSITDDI SPQKMLHPDI AKVPPSSPKA AKMMQRSMSD PKPLSPTAED
     SSRAQFQYTE GFMTKGSSSI TPSGTQKKVK RTLPNPPPEE ATAGTQSPYT SVGSVSRRRI
     CRTTTMARAK ILQDIDRELD LVERESAKLR KKQAELDEEE KEIDAKLRYL EMGINRRKEA
     LLKEREKRER AYLQGVAEER DYMSDSEVNN TRSTRIETQH GLERPRTAPQ TEFNQFMPPQ
     TQPETQFAPA TSPYGQYQYS SPALPTQAPT QFTQQSHYQQ QQPLYHQQVS PYQTQTAFQT
     GATMSFTPQA QPPPTQQPSY QLSSQMMVIQ PKPRQTPLYL EPKITTNYDV IRNQPLMIAP
     VSTDNNYAVS QLGSKYTTLD LRIGLDERNS IASSPISSIS ADSFYADIDQ HHTPRNYVLI
     DDIGELTKGT GALGSGFSLH EKDLTKTDRL LRTTEARRAQ EVSDFLAPLQ TSSRLHSYVK
     ADEDPMEDPY ELKLLKHQIK QEFRRGAESL DHLAGLSQYY HPEGSFRHFP KSEKYSIGRL
     TLEKQAAKQL PAALLYQKQS KHKKALIDPK LTKFSPIQES RDLEPDYSTY MTSSSTSSLG
     GITTRARLLQ DDITFGLRKN ITDQQKYMGA PLTSSIGAGL GAALGPTMRS TLQDEADKSY
     SSGSRSRPSS RPSSVYGLDL SLKRDSSSSS LRLKAQEAEP LDVSFSHAAP SGRTKPTSLP
     ISQSRGRIPI VAQNSEEESP LSPVGQPMGM ARAAAGPLPP ISADTRDQFG SSHSLPEVQQ
     HMREESRTRG YDRDIAFIMD DFQHAMSDSE AYHLRREETD WFDKPRESRL ENGHGLDRRL
     PEKLSHSRPP SQHQDQISCQ INGKPLQYIF PHARLKLLRD PKDHTVSGNG LGIRVVGGKE
     IPGSSGEIGA YIAKVLPGGN AEQTGKLIEG MQVLEWNGIP LTGKTYEEVQ NIIIQQCGEA
     EICVRLDLNM LSDSENPQHL ELHEPVKAVD KAKSPGVDPK QLAAELQKVS LQQAPLLASS
     GVEKSSHVHS GTTSATSSAV PSPGQPGSPS VSKKRHSSKP AEATKSGSHP ITGEIQLQIN
     YDKHLGNLII HILQARNLAP RDNNGYSDPF VKVYLLPGRG QVMVVQNASA EYKRRTKYVQ
     KSLNPEWNQT VIYKNISTEQ LKKKTLEVTV WDYDRFSSND FLGEVLIDLS SVSQLDNTPR
     WYPLKEQSEN IDHGKSHSGQ NSQQSPKPSV IKSRSHGIFP DPSKDMQVPT IEKSHSSPGS
     SKSSSEGHLR SHGPSRSQSK TSVTQTHLED AGAAIAAAEA AVQQLRLQPT AHKSGQSNHA
     RKQHRHSIAG VLPIQRTQSD NLPPPANDNK DQSQLALRKV MSDGPVKPEG ARSTNHRPAE
     SSVSTGSSVS SFGSGYSMDS EGSSSATGEN NLFPIPRIGK MSQNGQEPIK QSGVGLTDAE
     GKTQVMGEIK IALKKEMKTD GEQLIVEILQ CRNITYKFKS PDHLPDLYVK LYVVNVSTQK
     RVIKKKTRVC RHDREPSFNE TFRFSLSPAG HSLQILLVSN GGKFMKKTLI GEAYIWLDKV
     DLRKRTVNWH KLLVSSTQTH
 
 
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