ID   PCMD1_BOVIN             Reviewed;         356 AA.
AC   A2VDP2;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Protein-L-isoaspartate O-methyltransferase domain-containing protein 1;
GN   Name=PCMTD1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Basal ganglia;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane
CC       {ECO:0000250|UniProtKB:Q96MG8}; Lipid-anchor
CC       {ECO:0000250|UniProtKB:Q96MG8}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. L-
CC       isoaspartyl/D-aspartyl protein methyltransferase family. {ECO:0000305}.
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DR   EMBL; BC133335; AAI33336.1; -; mRNA.
DR   RefSeq; NP_001074995.1; NM_001081526.1.
DR   RefSeq; XP_005215466.1; XM_005215409.3.
DR   RefSeq; XP_005215467.1; XM_005215410.1.
DR   AlphaFoldDB; A2VDP2; -.
DR   SMR; A2VDP2; -.
DR   STRING; 9913.ENSBTAP00000023247; -.
DR   PaxDb; A2VDP2; -.
DR   PRIDE; A2VDP2; -.
DR   Ensembl; ENSBTAT00000023247; ENSBTAP00000023247; ENSBTAG00000017492.
DR   GeneID; 521261; -.
DR   KEGG; bta:521261; -.
DR   CTD; 115294; -.
DR   VEuPathDB; HostDB:ENSBTAG00000017492; -.
DR   VGNC; VGNC:53871; PCMTD1.
DR   eggNOG; KOG1661; Eukaryota.
DR   GeneTree; ENSGT00950000183032; -.
DR   HOGENOM; CLU_029295_0_0_1; -.
DR   InParanoid; A2VDP2; -.
DR   OMA; CTWERRD; -.
DR   OrthoDB; 1560133at2759; -.
DR   TreeFam; TF329329; -.
DR   Proteomes; UP000009136; Chromosome 14.
DR   Bgee; ENSBTAG00000017492; Expressed in oviduct epithelium and 105 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004719; F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity; IBA:GO_Central.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR000682; PCMT.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR11579; PTHR11579; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Lipoprotein; Membrane; Myristate; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q96MG8"
FT   CHAIN           2..356
FT                   /note="Protein-L-isoaspartate O-methyltransferase domain-
FT                   containing protein 1"
FT                   /id="PRO_0000293539"
FT   REGION          299..331
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        317..331
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        64
FT                   /evidence="ECO:0000250"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96MG8"
SQ   SEQUENCE   356 AA;  40474 MW;  5D6D126D0D4466A8 CRC64;
     MGGAVSAGED NDDLIDNLKE AQYIRTERVE QAFRAIDRGD YYLEGYRDNA YKDLAWKHGN
     IHLSAPCIYS EVMEALKLQP GLSFLNLGSG TGYLSTMVGL ILGPFGINHG IELHSDVVEY
     AKEKLESFIK NSDSFDKFEF CEPAFVVGNC LQIASDSHQY DRIYCGAGVQ KDHENYMKIL
     LKVGGILVMP IEDQLTQIMR TGQNTWESKN ILAVSFAPLV QPSKNDNGKP DSVGLPPCAV
     RNLQDLARIY IRRTLRNFIN DEMQAKGIPQ RAPPKRKRKR VKQRINTYVF VGNQLIPQPL
     DSEEDEKMEE DKEEEEKEPG EALKPEEPPQ NLLREKIMKL PLPESLKAYL TYFREK