ID   PCMD1_MOUSE             Reviewed;         357 AA.
AC   P59913;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   10-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Protein-L-isoaspartate O-methyltransferase domain-containing protein 1;
GN   Name=Pcmtd1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane
CC       {ECO:0000250|UniProtKB:Q96MG8}; Lipid-anchor
CC       {ECO:0000250|UniProtKB:Q96MG8}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. L-
CC       isoaspartyl/D-aspartyl protein methyltransferase family. {ECO:0000305}.
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DR   EMBL; BC052741; AAH52741.1; -; mRNA.
DR   CCDS; CCDS35508.1; -.
DR   RefSeq; NP_898849.1; NM_183028.3.
DR   AlphaFoldDB; P59913; -.
DR   SMR; P59913; -.
DR   BioGRID; 235163; 7.
DR   IntAct; P59913; 3.
DR   STRING; 10090.ENSMUSP00000059261; -.
DR   iPTMnet; P59913; -.
DR   PhosphoSitePlus; P59913; -.
DR   PaxDb; P59913; -.
DR   PeptideAtlas; P59913; -.
DR   PRIDE; P59913; -.
DR   ProteomicsDB; 301774; -.
DR   Antibodypedia; 11598; 95 antibodies from 16 providers.
DR   Ensembl; ENSMUST00000061280; ENSMUSP00000059261; ENSMUSG00000051285.
DR   GeneID; 319263; -.
DR   KEGG; mmu:319263; -.
DR   UCSC; uc007agb.1; mouse.
DR   CTD; 115294; -.
DR   MGI; MGI:2441773; Pcmtd1.
DR   VEuPathDB; HostDB:ENSMUSG00000051285; -.
DR   eggNOG; KOG1661; Eukaryota.
DR   GeneTree; ENSGT00950000183032; -.
DR   HOGENOM; CLU_029295_0_0_1; -.
DR   InParanoid; P59913; -.
DR   OMA; CTWERRD; -.
DR   OrthoDB; 1560133at2759; -.
DR   PhylomeDB; P59913; -.
DR   TreeFam; TF329329; -.
DR   BioGRID-ORCS; 319263; 1 hit in 71 CRISPR screens.
DR   ChiTaRS; Pcmtd1; mouse.
DR   PRO; PR:P59913; -.
DR   Proteomes; UP000000589; Chromosome 1.
DR   RNAct; P59913; protein.
DR   Bgee; ENSMUSG00000051285; Expressed in parotid gland and 255 other tissues.
DR   ExpressionAtlas; P59913; baseline and differential.
DR   Genevisible; P59913; MM.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004719; F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity; IBA:GO_Central.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR000682; PCMT.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR11579; PTHR11579; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Lipoprotein; Membrane; Myristate; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q96MG8"
FT   CHAIN           2..357
FT                   /note="Protein-L-isoaspartate O-methyltransferase domain-
FT                   containing protein 1"
FT                   /id="PRO_0000111926"
FT   REGION          299..331
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        313..331
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        64
FT                   /evidence="ECO:0000250"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96MG8"
SQ   SEQUENCE   357 AA;  40693 MW;  54CAFF921125408F CRC64;
     MGGAVSAGED NDDLIDNLKE AQYIRTERVE QAFRAIDRGD YYLEGYRDNA YKDLAWKHGN
     IHLSAPCIYS EVMEALKLQP GLSFLNLGSG TGYLSTMVGL ILGPFGINHG IELHSDVVEY
     AKEKLESFIK NSDSFDKFEF CEPAFVVGNC LQIASDSHQY DRIYCGAGVQ KDHENYMKIL
     LKVGGILVMP IEDQLTQIMR TGQNTWESKN ILAVSFAPLV QPSKNDNGTP DSVGLPPCAV
     RNLQDLARIY IRRTLRNFIN DEMQAKGIPQ RAPPKRKRKR VKQRINTYVF VGNQLIPQPL
     DSEEDEKMEE DSKEEEEKEH IEAMKREEPP QNLLREKIMK LPLPESLKAY LTYFRDK