ID   PCMD1_PONAB             Reviewed;         357 AA.
AC   Q5R7E5;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Protein-L-isoaspartate O-methyltransferase domain-containing protein 1;
GN   Name=PCMTD1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex, and Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane
CC       {ECO:0000250|UniProtKB:Q96MG8}; Lipid-anchor
CC       {ECO:0000250|UniProtKB:Q96MG8}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. L-
CC       isoaspartyl/D-aspartyl protein methyltransferase family. {ECO:0000305}.
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DR   EMBL; CR859527; CAH91695.1; -; mRNA.
DR   EMBL; CR860173; CAH92315.1; -; mRNA.
DR   RefSeq; NP_001125991.1; NM_001132519.1.
DR   RefSeq; XP_009242068.1; XM_009243793.1.
DR   AlphaFoldDB; Q5R7E5; -.
DR   SMR; Q5R7E5; -.
DR   STRING; 9601.ENSPPYP00000020838; -.
DR   Ensembl; ENSPPYT00000051845; ENSPPYP00000042768; ENSPPYG00000041146.
DR   GeneID; 100172930; -.
DR   KEGG; pon:100172930; -.
DR   CTD; 115294; -.
DR   eggNOG; KOG1661; Eukaryota.
DR   GeneTree; ENSGT00950000183032; -.
DR   HOGENOM; CLU_029295_0_0_1; -.
DR   InParanoid; Q5R7E5; -.
DR   OMA; CTWERRD; -.
DR   OrthoDB; 1560133at2759; -.
DR   TreeFam; TF329329; -.
DR   Proteomes; UP000001595; Chromosome 8.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004719; F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR000682; PCMT.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR11579; PTHR11579; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Lipoprotein; Membrane; Myristate; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q96MG8"
FT   CHAIN           2..357
FT                   /note="Protein-L-isoaspartate O-methyltransferase domain-
FT                   containing protein 1"
FT                   /id="PRO_0000293540"
FT   REGION          299..333
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        313..333
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        64
FT                   /evidence="ECO:0000250"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96MG8"
SQ   SEQUENCE   357 AA;  40675 MW;  84E98D02156F9C8E CRC64;
     MGGAVSAGED NDDLIDNLKE AQYIRTERVE QAFRAIDRGD YYLEGYRDNA YKDLAWKHGN
     IHLSAPCIYS EVMEALKLQP GLSFLNLGSG TGYLSTMVGL ILGPFGINHG IELHSDVVEY
     AKEKLESFIK NSDSFDKFEF CEPAFVVGNC LQIASDSHQY DRIYCGAGVQ KDHENYMKIL
     LKVGGILVMP IEDQLTQIMR TGQNTWESKN ILAVSFAPLV QPSKNDNGKP DSVGLPPCAV
     RNLQDLARIY IRRTLRNFIN DEMQAKGIPQ RAPPKRKRKR VKQRINTYVF VGNQLIPQPL
     DSEEDEKMEE DNKEEEEKDH NEAMKPEEPP QNLLREKIMK LPLPESLKAY LTYFRDK