ID   PCMD2_BOVIN             Reviewed;         361 AA.
AC   Q58CZ2; Q0VCV2;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Protein-L-isoaspartate O-methyltransferase domain-containing protein 2;
GN   Name=PCMTD2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. L-
CC       isoaspartyl/D-aspartyl protein methyltransferase family. {ECO:0000305}.
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DR   EMBL; BT021805; AAX46652.1; -; mRNA.
DR   EMBL; BC119984; AAI19985.1; -; mRNA.
DR   RefSeq; NP_001019650.1; NM_001024479.2.
DR   RefSeq; XP_005214620.1; XM_005214563.3.
DR   AlphaFoldDB; Q58CZ2; -.
DR   SMR; Q58CZ2; -.
DR   STRING; 9913.ENSBTAP00000042405; -.
DR   PaxDb; Q58CZ2; -.
DR   PRIDE; Q58CZ2; -.
DR   GeneID; 505807; -.
DR   KEGG; bta:505807; -.
DR   CTD; 55251; -.
DR   eggNOG; KOG1661; Eukaryota.
DR   HOGENOM; CLU_029295_0_0_1; -.
DR   InParanoid; Q58CZ2; -.
DR   OrthoDB; 1560133at2759; -.
DR   TreeFam; TF329329; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0004719; F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity; IBA:GO_Central.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR000682; PCMT.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR11579; PTHR11579; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Lipoprotein; Myristate; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000255"
FT   CHAIN           2..361
FT                   /note="Protein-L-isoaspartate O-methyltransferase domain-
FT                   containing protein 2"
FT                   /id="PRO_0000244564"
FT   REGION          303..335
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        311..327
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        64
FT                   /evidence="ECO:0000250"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   361 AA;  40786 MW;  EEC92608E80B94E7 CRC64;
     MGGAVSAGED NDELIDNLKE AQYIRSELVE QAFRAIDRAD YYLEEFKENA YKDLAWKHGN
     IHLSAPCIYS EVMEALDLQP GLSFLNLGSG TGYLSSMVGL ILGPFGVNHG VELHSDVTEY
     AKQKLDFFIR TSDSFDKFDF CEPSFVTGNC LEISPDCSQY DRVYCGAGVQ KEHEEYMKSL
     LKVGGILVMP LEEKLTKITR TGPSAWETKK ILAVSFAPLI QPCQSESGKS RLVQLPPLAV
     RSLQDLARIA IRGTIKKVIH QEAVNKNGNG LKNTPRFKRR RVRRRRLETI VFLDKEVFAS
     RISNPSDDNS SGDLEEERRE EEATTPPDAK PEPPVNFLRE KVLSLPLPDP LKYYLLYYRE
     K