PCMD2_MOUSE
ID PCMD2_MOUSE Reviewed; 359 AA.
AC Q8BHD8; Q3UKB7; Q8BJT6; Q8BK38; Q8C0H6; Q8R1D5;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Protein-L-isoaspartate O-methyltransferase domain-containing protein 2;
GN Name=Pcmtd2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD;
RC TISSUE=Aorta, Pituitary, Placenta, Testis, Thymus, and Vein;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Eye, Mammary cancer, and Retina;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. L-
CC isoaspartyl/D-aspartyl protein methyltransferase family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC37785.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK031335; BAC27352.1; -; mRNA.
DR EMBL; AK077319; BAC36747.1; -; mRNA.
DR EMBL; AK079927; BAC37785.1; ALT_INIT; mRNA.
DR EMBL; AK088800; BAC40579.1; -; mRNA.
DR EMBL; AK146080; BAE26884.1; -; mRNA.
DR EMBL; BC024791; AAH24791.1; -; mRNA.
DR EMBL; BC031360; AAH31360.1; -; mRNA.
DR EMBL; BC040385; AAH40385.1; -; mRNA.
DR CCDS; CCDS17224.1; -.
DR RefSeq; NP_001278140.1; NM_001291211.1.
DR RefSeq; NP_705822.1; NM_153594.3.
DR AlphaFoldDB; Q8BHD8; -.
DR SMR; Q8BHD8; -.
DR BioGRID; 232844; 5.
DR IntAct; Q8BHD8; 3.
DR STRING; 10090.ENSMUSP00000029116; -.
DR iPTMnet; Q8BHD8; -.
DR PhosphoSitePlus; Q8BHD8; -.
DR EPD; Q8BHD8; -.
DR MaxQB; Q8BHD8; -.
DR PaxDb; Q8BHD8; -.
DR PeptideAtlas; Q8BHD8; -.
DR PRIDE; Q8BHD8; -.
DR ProteomicsDB; 288075; -.
DR Antibodypedia; 30018; 83 antibodies from 17 providers.
DR Ensembl; ENSMUST00000029116; ENSMUSP00000029116; ENSMUSG00000027589.
DR GeneID; 245867; -.
DR KEGG; mmu:245867; -.
DR UCSC; uc008onu.2; mouse.
DR CTD; 55251; -.
DR MGI; MGI:1923927; Pcmtd2.
DR VEuPathDB; HostDB:ENSMUSG00000027589; -.
DR eggNOG; KOG1661; Eukaryota.
DR GeneTree; ENSGT00950000183032; -.
DR HOGENOM; CLU_029295_0_0_1; -.
DR InParanoid; Q8BHD8; -.
DR OMA; LIQPCRS; -.
DR OrthoDB; 1560133at2759; -.
DR PhylomeDB; Q8BHD8; -.
DR TreeFam; TF329329; -.
DR BioGRID-ORCS; 245867; 4 hits in 71 CRISPR screens.
DR ChiTaRS; Pcmtd2; mouse.
DR PRO; PR:Q8BHD8; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8BHD8; protein.
DR Bgee; ENSMUSG00000027589; Expressed in retinal neural layer and 247 other tissues.
DR ExpressionAtlas; Q8BHD8; baseline and differential.
DR Genevisible; Q8BHD8; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0004719; F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity; IBA:GO_Central.
DR Gene3D; 3.40.50.150; -; 1.
DR InterPro; IPR000682; PCMT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR11579; PTHR11579; 1.
DR SUPFAM; SSF53335; SSF53335; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Lipoprotein; Myristate; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000255"
FT CHAIN 2..359
FT /note="Protein-L-isoaspartate O-methyltransferase domain-
FT containing protein 2"
FT /id="PRO_0000111928"
FT REGION 301..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 64
FT /evidence="ECO:0000250"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000255"
FT CONFLICT 14
FT /note="L -> I (in Ref. 1; BAC27352)"
FT /evidence="ECO:0000305"
FT CONFLICT 207..208
FT /note="ET -> DI (in Ref. 1; BAC36747)"
FT /evidence="ECO:0000305"
FT CONFLICT 291
FT /note="L -> S (in Ref. 1; BAC27352)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 359 AA; 40756 MW; 2CBAB9F55C87C4DC CRC64;
MGGAVSAGED NDELIDNLKE AQYIRTDLVE QAFRAIDRAD YYLEEFKENA YKDLAWKHGN
IHLSAPCIYS EVMEALDLQP GLSFLNLGSG TGYLSSMVGL ILGPFGVNHG VELHSDVTEY
AKQKLDVFIR TSDSFDKFDF CEPSFVTGNC LEIAPDCCQY DRVYCGAGVQ KEHEEYMKNL
LKVGGILVMP LEEKLTKITR TGPSAWETKK ILAVSFAPLV QPCRSESGQS RLVQLPPPAV
RSLQDLARLA IRGSIKRAMR QEATRGGGLK NTPMFKRRRV RRRRMETIVF LDKEVFASRI
SNPSDDTSCE DAEEDRREVA ERTLQETKPE PPVNFLRQRV LRLPLPDPLK YYLLYYREK
