PCNA1_AERPE
ID PCNA1_AERPE Reviewed; 247 AA.
AC Q9YFT8;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 21-FEB-2001, sequence version 2.
DT 25-MAY-2022, entry version 109.
DE RecName: Full=DNA polymerase sliding clamp 1 {ECO:0000255|HAMAP-Rule:MF_00317};
DE AltName: Full=Proliferating cell nuclear antigen homolog 1 {ECO:0000255|HAMAP-Rule:MF_00317};
DE Short=PCNA 1 {ECO:0000255|HAMAP-Rule:MF_00317};
GN Name=pcn1 {ECO:0000255|HAMAP-Rule:MF_00317}; Synonyms=pcnA;
GN OrderedLocusNames=APE_0162;
OS Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 /
OS K1).
OC Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC Desulfurococcaceae; Aeropyrum.
OX NCBI_TaxID=272557;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1;
RX PubMed=10382966; DOI=10.1093/dnares/6.2.83;
RA Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K.,
RA Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A.,
RA Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S.,
RA Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A.,
RA Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H.;
RT "Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon,
RT Aeropyrum pernix K1.";
RL DNA Res. 6:83-101(1999).
CC -!- FUNCTION: Sliding clamp subunit that acts as a moving platform for DNA
CC processing. Responsible for tethering the catalytic subunit of DNA
CC polymerase and other proteins to DNA during high-speed replication.
CC {ECO:0000255|HAMAP-Rule:MF_00317}.
CC -!- SUBUNIT: Heterotrimer. The subunits circularize to form a toroid; DNA
CC passes through its center. Replication factor C (RFC) is required to
CC load the toroid on the DNA (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PCNA family. {ECO:0000255|HAMAP-
CC Rule:MF_00317}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA79073.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; BA000002; BAA79073.1; ALT_INIT; Genomic_DNA.
DR PIR; G72771; G72771.
DR PDB; 6AIG; X-ray; 2.00 A; A=1-247.
DR PDBsum; 6AIG; -.
DR AlphaFoldDB; Q9YFT8; -.
DR SMR; Q9YFT8; -.
DR STRING; 272557.APE_0162; -.
DR PRIDE; Q9YFT8; -.
DR EnsemblBacteria; BAA79073; BAA79073; APE_0162.
DR KEGG; ape:APE_0162; -.
DR eggNOG; arCOG00488; Archaea.
DR OMA; TIRKDPN; -.
DR Proteomes; UP000002518; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030337; F:DNA polymerase processivity factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00317; DNApol_clamp_arch; 1.
DR InterPro; IPR000730; Pr_cel_nuc_antig.
DR InterPro; IPR022649; Pr_cel_nuc_antig_C.
DR InterPro; IPR022659; Pr_cel_nuc_antig_CS.
DR InterPro; IPR022648; Pr_cel_nuc_antig_N.
DR PANTHER; PTHR11352:SF0; PTHR11352:SF0; 1.
DR Pfam; PF02747; PCNA_C; 1.
DR Pfam; PF00705; PCNA_N; 1.
DR PROSITE; PS01251; PCNA_1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; DNA replication; DNA-binding; Reference proteome.
FT CHAIN 1..247
FT /note="DNA polymerase sliding clamp 1"
FT /id="PRO_0000149189"
FT STRAND 1..5
FT /evidence="ECO:0007829|PDB:6AIG"
FT HELIX 6..17
FT /evidence="ECO:0007829|PDB:6AIG"
FT STRAND 21..28
FT /evidence="ECO:0007829|PDB:6AIG"
FT STRAND 31..37
FT /evidence="ECO:0007829|PDB:6AIG"
FT STRAND 41..50
FT /evidence="ECO:0007829|PDB:6AIG"
FT HELIX 51..53
FT /evidence="ECO:0007829|PDB:6AIG"
FT STRAND 54..59
FT /evidence="ECO:0007829|PDB:6AIG"
FT STRAND 64..71
FT /evidence="ECO:0007829|PDB:6AIG"
FT HELIX 72..79
FT /evidence="ECO:0007829|PDB:6AIG"
FT STRAND 87..92
FT /evidence="ECO:0007829|PDB:6AIG"
FT STRAND 94..112
FT /evidence="ECO:0007829|PDB:6AIG"
FT STRAND 129..135
FT /evidence="ECO:0007829|PDB:6AIG"
FT HELIX 136..149
FT /evidence="ECO:0007829|PDB:6AIG"
FT STRAND 151..158
FT /evidence="ECO:0007829|PDB:6AIG"
FT STRAND 161..166
FT /evidence="ECO:0007829|PDB:6AIG"
FT STRAND 175..179
FT /evidence="ECO:0007829|PDB:6AIG"
FT STRAND 185..192
FT /evidence="ECO:0007829|PDB:6AIG"
FT STRAND 194..199
FT /evidence="ECO:0007829|PDB:6AIG"
FT HELIX 200..206
FT /evidence="ECO:0007829|PDB:6AIG"
FT HELIX 207..212
FT /evidence="ECO:0007829|PDB:6AIG"
FT STRAND 214..220
FT /evidence="ECO:0007829|PDB:6AIG"
FT STRAND 226..231
FT /evidence="ECO:0007829|PDB:6AIG"
FT STRAND 237..242
FT /evidence="ECO:0007829|PDB:6AIG"
SQ SEQUENCE 247 AA; 27667 MW; DAF4B406FF54EFB1 CRC64;
MFRYEAKVFK ELVDSVSKIL DEGLFIITGE GLRLRGMDPA RVALVDIEIP SSSFFDFYMA
GDVERVELGV NMETLKGVVA RAKKGDQLEV RVREDKVLFI VESVVLRRYL LPNLEVIVDV
PEDISLEFDA TATVIADVVK KTLRDVELVG DIVEFDAGED YLSIRSVGPE RRRVETRLTR
ESPALIDLEV KEPATSRYDV GYLKRMLGVA KIAESIELSF STDKPLKMVF KSPDGSRVTY
LLAPSTG
