PCNA1_PYRAE
ID PCNA1_PYRAE Reviewed; 249 AA.
AC Q8ZTY0;
DT 05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 05-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=DNA polymerase sliding clamp 1 {ECO:0000255|HAMAP-Rule:MF_00317};
DE AltName: Full=Proliferating cell nuclear antigen homolog 1 {ECO:0000255|HAMAP-Rule:MF_00317};
DE Short=PCNA 1 {ECO:0000255|HAMAP-Rule:MF_00317};
GN Name=pcn1 {ECO:0000255|HAMAP-Rule:MF_00317}; OrderedLocusNames=PAE3038;
OS Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP
OS 104966 / NBRC 100827 / IM2).
OC Archaea; Crenarchaeota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC Pyrobaculum.
OX NCBI_TaxID=178306;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2;
RX PubMed=11371158; DOI=10.1006/jmbi.2001.4669;
RA Slupska M.M., King A.G., Fitz-Gibbon S., Besemer J., Borodovsky M.,
RA Miller J.H.;
RT "Leaderless transcripts of the crenarchaeal hyperthermophile Pyrobaculum
RT aerophilum.";
RL J. Mol. Biol. 309:347-360(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2;
RX PubMed=11792869; DOI=10.1073/pnas.241636498;
RA Fitz-Gibbon S.T., Ladner H., Kim U.-J., Stetter K.O., Simon M.I.,
RA Miller J.H.;
RT "Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum
RT aerophilum.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002).
CC -!- FUNCTION: Sliding clamp subunit that acts as a moving platform for DNA
CC processing. Responsible for tethering the catalytic subunit of DNA
CC polymerase and other proteins to DNA during high-speed replication.
CC {ECO:0000255|HAMAP-Rule:MF_00317}.
CC -!- SUBUNIT: Homotrimer. The subunits circularize to form a toroid; DNA
CC passes through its center. Replication factor C (RFC) is required to
CC load the toroid on the DNA. {ECO:0000255|HAMAP-Rule:MF_00317}.
CC -!- SIMILARITY: Belongs to the PCNA family. {ECO:0000255|HAMAP-
CC Rule:MF_00317}.
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DR EMBL; AY026765; AAK13025.1; -; Genomic_DNA.
DR EMBL; AE009441; AAL64629.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8ZTY0; -.
DR SMR; Q8ZTY0; -.
DR STRING; 178306.PAE3038; -.
DR EnsemblBacteria; AAL64629; AAL64629; PAE3038.
DR KEGG; pai:PAE3038; -.
DR PATRIC; fig|178306.9.peg.2286; -.
DR eggNOG; arCOG00488; Archaea.
DR HOGENOM; CLU_043978_1_0_2; -.
DR InParanoid; Q8ZTY0; -.
DR OMA; EMKLINM; -.
DR Proteomes; UP000002439; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030337; F:DNA polymerase processivity factor activity; IBA:GO_Central.
DR GO; GO:0006272; P:leading strand elongation; IBA:GO_Central.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00317; DNApol_clamp_arch; 1.
DR InterPro; IPR000730; Pr_cel_nuc_antig.
DR InterPro; IPR022649; Pr_cel_nuc_antig_C.
DR InterPro; IPR022659; Pr_cel_nuc_antig_CS.
DR InterPro; IPR022648; Pr_cel_nuc_antig_N.
DR PANTHER; PTHR11352:SF0; PTHR11352:SF0; 1.
DR Pfam; PF02747; PCNA_C; 1.
DR Pfam; PF00705; PCNA_N; 1.
DR PRINTS; PR00339; PCNACYCLIN.
DR TIGRFAMs; TIGR00590; pcna; 1.
DR PROSITE; PS01251; PCNA_1; 1.
PE 3: Inferred from homology;
KW DNA replication; DNA-binding; Reference proteome.
FT CHAIN 1..249
FT /note="DNA polymerase sliding clamp 1"
FT /id="PRO_0000149204"
SQ SEQUENCE 249 AA; 27696 MW; 62A37CD80CCC3538 CRC64;
MAKQVLTYID AKEFAYIIDS ISVLVEEANF LIRNDGLYLR ALDVSRTAMV DLAIPKESFE
EFPEVEELRF GLNFKELKKL LRRVKKGDKI SMEFEEGRVR IKLIGKSVRS IVVPSIEVVG
EELPTPKVVY TAMVKAASDV LATAVKDADA VADEVKFEAS EEALIISASS DKGEVEVKLD
KNSELVYEFD VKEPASARFS LEYLVDITSK TSKISDIVTI ELATAKPIYL SFDIPAGGKI
SYFIAPRVE
