ID   PCNA2_AERPE             Reviewed;         251 AA.
AC   Q9Y9V7;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=DNA polymerase sliding clamp 2 {ECO:0000255|HAMAP-Rule:MF_00317};
DE   AltName: Full=DNA polymerase sliding clamp B1 {ECO:0000255|HAMAP-Rule:MF_00317};
DE   AltName: Full=Proliferating cell nuclear antigen homolog 3 {ECO:0000255|HAMAP-Rule:MF_00317};
DE            Short=PCNA 3 {ECO:0000255|HAMAP-Rule:MF_00317};
GN   Name=pcn2 {ECO:0000255|HAMAP-Rule:MF_00317}; Synonyms=pcnB1;
GN   OrderedLocusNames=APE_2182;
OS   Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 /
OS   K1).
OC   Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC   Desulfurococcaceae; Aeropyrum.
OX   NCBI_TaxID=272557;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1;
RX   PubMed=10382966; DOI=10.1093/dnares/6.2.83;
RA   Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K.,
RA   Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A.,
RA   Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S.,
RA   Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A.,
RA   Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H.;
RT   "Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon,
RT   Aeropyrum pernix K1.";
RL   DNA Res. 6:83-101(1999).
CC   -!- FUNCTION: Sliding clamp subunit that acts as a moving platform for DNA
CC       processing. Responsible for tethering the catalytic subunit of DNA
CC       polymerase and other proteins to DNA during high-speed replication.
CC       {ECO:0000255|HAMAP-Rule:MF_00317}.
CC   -!- SUBUNIT: Heterotrimer. The subunits circularize to form a toroid; DNA
CC       passes through its center. Replication factor C (RFC) is required to
CC       load the toroid on the DNA (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PCNA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00317}.
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DR   EMBL; BA000002; BAA81193.1; -; Genomic_DNA.
DR   PIR; A72526; A72526.
DR   AlphaFoldDB; Q9Y9V7; -.
DR   SMR; Q9Y9V7; -.
DR   STRING; 272557.APE_2182; -.
DR   EnsemblBacteria; BAA81193; BAA81193; APE_2182.
DR   KEGG; ape:APE_2182; -.
DR   eggNOG; arCOG00488; Archaea.
DR   OMA; NASKMKY; -.
DR   Proteomes; UP000002518; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030337; F:DNA polymerase processivity factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00317; DNApol_clamp_arch; 1.
DR   InterPro; IPR000730; Pr_cel_nuc_antig.
DR   InterPro; IPR022659; Pr_cel_nuc_antig_CS.
DR   InterPro; IPR022648; Pr_cel_nuc_antig_N.
DR   PANTHER; PTHR11352:SF0; PTHR11352:SF0; 1.
DR   Pfam; PF00705; PCNA_N; 1.
DR   PROSITE; PS01251; PCNA_1; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; Reference proteome.
FT   CHAIN           1..251
FT                   /note="DNA polymerase sliding clamp 2"
FT                   /id="PRO_0000149190"
SQ   SEQUENCE   251 AA;  28618 MW;  AA93412CB3847A1A CRC64;
     MFRLVYTASS KFKYIAQTLA KINDEGVFEF SLDGLRAWIM SPDKTSLAIL EMPSLSFEEY
     MVEEEMRVVL RTDELNKISK RATRNDDIIF QWNAEEQALE VELRDRKLGF SRKFLVPATS
     VGAEEMRRLK LEPTVSFTIL TDDLKAMIQD VKVVGDFAEF EASEGQVVVR SQAEEKEYEW
     VMKPGDVLLS LEVEEDAKSI YSRQVLEIAT KPVGAAESVK VSFASDYPMK IEYTFPNGER
     MELYMAPSLA G