ID   PCNA2_DAUCA             Reviewed;         365 AA.
AC   Q00265;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Proliferating cell nuclear antigen large form;
DE            Short=PCNA;
DE   AltName: Full=Cyclin;
OS   Daucus carota (Wild carrot).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Apiales; Apiaceae; Apioideae; Scandiceae; Daucinae;
OC   Daucus; Daucus sect. Daucus.
OX   NCBI_TaxID=4039;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=cv. Kurodagosun;
RX   PubMed=1346518; DOI=10.1111/j.1432-1033.1992.tb16559.x;
RA   Hata S., Kouchi H., Tanaka Y., Minami E., Matsumoto T., Suzuka I.,
RA   Hashimoto J.;
RT   "Identification of carrot cDNA clones encoding a second putative
RT   proliferating cell-nuclear antigen, DNA polymerase delta auxiliary
RT   protein.";
RL   Eur. J. Biochem. 203:367-371(1992).
CC   -!- FUNCTION: This protein is an auxiliary protein of DNA polymerase delta
CC       and may be involved in DNA replication as its carrot homolog, typical
CC       PCNA. The larger PCNA is perhaps processed thus bestowing on it exactly
CC       the same function as its homolog.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the PCNA family. {ECO:0000305}.
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DR   EMBL; X62976; CAB56779.1; ALT_SEQ; mRNA.
DR   EMBL; D10556; BAA20971.1; -; Genomic_DNA.
DR   PIR; S20591; S20591.
DR   AlphaFoldDB; Q00265; -.
DR   SMR; Q00265; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030337; F:DNA polymerase processivity factor activity; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   HAMAP; MF_00317; DNApol_clamp_arch; 1.
DR   InterPro; IPR000730; Pr_cel_nuc_antig.
DR   InterPro; IPR022649; Pr_cel_nuc_antig_C.
DR   InterPro; IPR022659; Pr_cel_nuc_antig_CS.
DR   InterPro; IPR022648; Pr_cel_nuc_antig_N.
DR   Pfam; PF02747; PCNA_C; 1.
DR   Pfam; PF00705; PCNA_N; 1.
DR   PRINTS; PR00339; PCNACYCLIN.
DR   TIGRFAMs; TIGR00590; pcna; 1.
DR   PROSITE; PS01251; PCNA_1; 1.
DR   PROSITE; PS00293; PCNA_2; 1.
PE   2: Evidence at transcript level;
KW   DNA replication; DNA-binding; Nucleus.
FT   CHAIN           1..365
FT                   /note="Proliferating cell nuclear antigen large form"
FT                   /id="PRO_0000149182"
FT   DNA_BIND        61..80
FT                   /evidence="ECO:0000255"
FT   REGION          262..365
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        264..285
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        286..305
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        319..359
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         114
FT                   /note="F -> Y"
FT   VARIANT         296
FT                   /note="A -> V"
SQ   SEQUENCE   365 AA;  40102 MW;  84094DE94CA0D567 CRC64;
     MLELRLVQGG LLKKVLESIK DLVNDANFDC SASGFSLQAM DSSHVALVAV LLRSEGFEHY
     RCDRNISMGM NLGNMAKMLR CAGNDDIVTM KADDDGDVIT FMFESPTQDK ISDFEMKLMD
     IDSEHLGIPE SEYEAIVRMP SAEFARICKD LSTIGDTVVI SVTKEGVKFS TRGDIGTANI
     VCRQNTSVDK PEDATIIEMQ ETVSLTFALR YMNSFTKATP LANQVTISLS SELPVVVEYK
     IAEMGYIRYY LAPKIEEEDE AANYAQPAQN SAAAATSNNG TKKNEGNNKV DSKKRAIKSE
     FVDDSEAATD AQPQAKAKTK TEAGEDDDVE VMDTKPKNEP DDGDEVMETK PKTESNGEVE
     VMDIE