PCNA2_PLAF7
ID PCNA2_PLAF7 Reviewed; 264 AA.
AC Q7KQJ9; Q8I6B5; Q8WSN0;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Proliferating cell nuclear antigen 2 {ECO:0000303|PubMed:12413950};
DE Short=PfPCNA2 {ECO:0000303|PubMed:12413950};
GN Name=PCNA2 {ECO:0000303|PubMed:12413950};
GN ORFNames=PF3D7_1226600 {ECO:0000312|EMBL:CZT99425.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000312|Proteomes:UP000001450};
RN [1] {ECO:0000312|EMBL:AAN34792.1}
RP NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, AND DEVELOPMENTAL STAGE.
RX PubMed=12413950; DOI=10.1016/s0006-291x(02)02436-1;
RA Patterson S., Whittle C., Robert C., Chakrabarti D.;
RT "Molecular characterization and expression of an alternate proliferating
RT cell nuclear antigen homologue, PfPCNA2, in Plasmodium falciparum.";
RL Biochem. Biophys. Res. Commun. 298:371-376(2002).
RN [2] {ECO:0000312|EMBL:AAG37983.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBUNIT, AND DEVELOPMENTAL STAGE.
RX PubMed=12464414; DOI=10.1016/s0020-7519(02)00162-5;
RA Li J.L., Warren A.V., Cox L.S.;
RT "Identification of a second proliferating cell nuclear antigen in the human
RT malarial pathogen Plasmodium falciparum.";
RL Int. J. Parasitol. 32:1683-1692(2002).
RN [3] {ECO:0000312|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7 {ECO:0000312|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [4] {ECO:0000305}
RP FUNCTION, SUBUNIT, INTERACTION WITH ORC1 AND FEN1, SUBCELLULAR LOCATION,
RP DEVELOPMENTAL STAGE, AND INDUCTION.
RX PubMed=26251451; DOI=10.1042/bj20150452;
RA Mitra P., Banu K., Deshmukh A.S., Subbarao N., Dhar S.K.;
RT "Functional dissection of proliferating-cell nuclear antigens (1 and 2) in
RT human malarial parasite Plasmodium falciparum: possible involvement in DNA
RT replication and DNA damage response.";
RL Biochem. J. 470:115-129(2015).
CC -!- FUNCTION: May be involved in DNA damage response (PubMed:26251451).
CC Appears not to be involved in DNA replication in trophozoites
CC (PubMed:26251451). {ECO:0000269|PubMed:26251451}.
CC -!- SUBUNIT: Homotrimer (PubMed:12413950, PubMed:12464414,
CC PubMed:26251451). Oligomer (PubMed:12413950). Interacts with ORC1 (via
CC PIP-box motif) (PubMed:26251451). Interacts with FEN1
CC (PubMed:26251451). {ECO:0000269|PubMed:12413950,
CC ECO:0000269|PubMed:12464414, ECO:0000269|PubMed:26251451}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26251451}. Chromosome
CC {ECO:0000269|PubMed:26251451}. Cytoplasm {ECO:0000269|PubMed:26251451}.
CC Note=Unlike PCNA1, does not localize to nuclear foci (PubMed:26251451).
CC Enriched in the nucleus in response to DNA damage (PubMed:26251451).
CC {ECO:0000269|PubMed:26251451}.
CC -!- DEVELOPMENTAL STAGE: Expressed during the asexual blood stage;
CC expression is low at the ring stage, increases in trophozoites and
CC early schizonts and sharply decreases in late schizonts (at protein
CC level) (PubMed:12413950, PubMed:12464414, PubMed:26251451). Expressed
CC during the sexual blood stage (PubMed:12464414).
CC {ECO:0000269|PubMed:12413950, ECO:0000269|PubMed:12464414,
CC ECO:0000269|PubMed:26251451}.
CC -!- INDUCTION: Induced by DNA damage (at protein level).
CC {ECO:0000269|PubMed:26251451}.
CC -!- SIMILARITY: Belongs to the PCNA family.
CC {ECO:0000255|RuleBase:RU003671}.
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DR EMBL; AF544241; AAN34792.1; -; mRNA.
DR EMBL; AF056205; AAG37983.1; -; Genomic_DNA.
DR EMBL; LN999947; CZT99425.1; -; Genomic_DNA.
DR RefSeq; XP_001350663.1; XM_001350627.1.
DR AlphaFoldDB; Q7KQJ9; -.
DR SMR; Q7KQJ9; -.
DR STRING; 5833.PFL1285c; -.
DR PRIDE; Q7KQJ9; -.
DR EnsemblProtists; CZT99425; CZT99425; PF3D7_1226600.
DR GeneID; 811309; -.
DR KEGG; pfa:PF3D7_1226600; -.
DR VEuPathDB; PlasmoDB:PF3D7_1226600; -.
DR VEuPathDB; PlasmoDB:Pf7G8-2_000376400; -.
DR VEuPathDB; PlasmoDB:Pf7G8_120032100; -.
DR VEuPathDB; PlasmoDB:PfCD01_120031500; -.
DR VEuPathDB; PlasmoDB:PfDd2_120031600; -.
DR VEuPathDB; PlasmoDB:PfGA01_120031300; -.
DR VEuPathDB; PlasmoDB:PfGB4_120032000; -.
DR VEuPathDB; PlasmoDB:PfGN01_120032600; -.
DR VEuPathDB; PlasmoDB:PfHB3_120031400; -.
DR VEuPathDB; PlasmoDB:PfIT_120031700; -.
DR VEuPathDB; PlasmoDB:PfKE01_120031600; -.
DR VEuPathDB; PlasmoDB:PfKH01_120033000; -.
DR VEuPathDB; PlasmoDB:PfKH02_120031700; -.
DR VEuPathDB; PlasmoDB:PfML01_120031800; -.
DR VEuPathDB; PlasmoDB:PfNF135_120031800; -.
DR VEuPathDB; PlasmoDB:PfNF166_120033200; -.
DR VEuPathDB; PlasmoDB:PfNF54_120031400; -.
DR VEuPathDB; PlasmoDB:PfSD01_120031500; -.
DR VEuPathDB; PlasmoDB:PfSN01_120032200; -.
DR VEuPathDB; PlasmoDB:PfTG01_120031500; -.
DR HOGENOM; CLU_043978_3_0_1; -.
DR InParanoid; Q7KQJ9; -.
DR OMA; TIRKDPN; -.
DR PhylomeDB; Q7KQJ9; -.
DR Proteomes; UP000001450; Chromosome 12.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0043626; C:PCNA complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030337; F:DNA polymerase processivity factor activity; IBA:GO_Central.
DR GO; GO:0006272; P:leading strand elongation; IBA:GO_Central.
DR GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR GO; GO:0045739; P:positive regulation of DNA repair; IDA:UniProtKB.
DR GO; GO:0051259; P:protein complex oligomerization; IDA:GeneDB.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR GO; GO:0019985; P:translesion synthesis; IBA:GO_Central.
DR HAMAP; MF_00317; DNApol_clamp_arch; 1.
DR InterPro; IPR000730; Pr_cel_nuc_antig.
DR InterPro; IPR022649; Pr_cel_nuc_antig_C.
DR InterPro; IPR022659; Pr_cel_nuc_antig_CS.
DR InterPro; IPR022648; Pr_cel_nuc_antig_N.
DR PANTHER; PTHR11352:SF0; PTHR11352:SF0; 1.
DR Pfam; PF02747; PCNA_C; 1.
DR Pfam; PF00705; PCNA_N; 1.
DR PRINTS; PR00339; PCNACYCLIN.
DR TIGRFAMs; TIGR00590; pcna; 1.
DR PROSITE; PS01251; PCNA_1; 1.
PE 1: Evidence at protein level;
KW Chromosome; Cytoplasm; DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..264
FT /note="Proliferating cell nuclear antigen 2"
FT /id="PRO_0000454947"
SQ SEQUENCE 264 AA; 30163 MW; 6C5DF3EE6498CCF6 CRC64;
MFECRIDGQF FKKLFETLKD ICTEVNLECD ENGIKMQSMD CSHVSLVDLN IVSDFFQHYR
CDKNCVLGIS INFMLKILSV IKEKSTVFLF KEDNENDAVL NIGIIDEEEQ SSADDSLEIQ
VKLINAQKEH LEIPQSEYHC QCTMKSKKFQ EFTKYLNSIG DNVSISMKKD AMILSTTGSD
IKVTKQFTND MTDISITCTK SVSQEFATRY LVMFSRASSL SDEVLISLSP HIPISIKFNF
KQQLTDLQDP SHLTFFLAPK IGDY
