ID   PCNA2_PYRAE             Reviewed;         256 AA.
AC   Q8ZYL6;
DT   05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   05-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=DNA polymerase sliding clamp 2 {ECO:0000255|HAMAP-Rule:MF_00317};
DE   AltName: Full=Proliferating cell nuclear antigen homolog 2 {ECO:0000255|HAMAP-Rule:MF_00317};
DE            Short=PCNA 2 {ECO:0000255|HAMAP-Rule:MF_00317};
GN   Name=pcn2 {ECO:0000255|HAMAP-Rule:MF_00317}; OrderedLocusNames=PAE0720;
OS   Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP
OS   104966 / NBRC 100827 / IM2).
OC   Archaea; Crenarchaeota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC   Pyrobaculum.
OX   NCBI_TaxID=178306;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2;
RX   PubMed=11792869; DOI=10.1073/pnas.241636498;
RA   Fitz-Gibbon S.T., Ladner H., Kim U.-J., Stetter K.O., Simon M.I.,
RA   Miller J.H.;
RT   "Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum
RT   aerophilum.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002).
CC   -!- FUNCTION: Sliding clamp subunit that acts as a moving platform for DNA
CC       processing. Responsible for tethering the catalytic subunit of DNA
CC       polymerase and other proteins to DNA during high-speed replication.
CC       {ECO:0000255|HAMAP-Rule:MF_00317}.
CC   -!- SUBUNIT: Homotrimer. The subunits circularize to form a toroid; DNA
CC       passes through its center. Replication factor C (RFC) is required to
CC       load the toroid on the DNA. {ECO:0000255|HAMAP-Rule:MF_00317}.
CC   -!- SIMILARITY: Belongs to the PCNA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00317}.
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DR   EMBL; AE009441; AAL62977.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8ZYL6; -.
DR   SMR; Q8ZYL6; -.
DR   STRING; 178306.PAE0720; -.
DR   EnsemblBacteria; AAL62977; AAL62977; PAE0720.
DR   KEGG; pai:PAE0720; -.
DR   PATRIC; fig|178306.9.peg.522; -.
DR   eggNOG; arCOG00488; Archaea.
DR   HOGENOM; CLU_043978_1_0_2; -.
DR   InParanoid; Q8ZYL6; -.
DR   OMA; EPRYAFE; -.
DR   Proteomes; UP000002439; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030337; F:DNA polymerase processivity factor activity; IBA:GO_Central.
DR   GO; GO:0006272; P:leading strand elongation; IBA:GO_Central.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00317; DNApol_clamp_arch; 1.
DR   InterPro; IPR000730; Pr_cel_nuc_antig.
DR   InterPro; IPR022649; Pr_cel_nuc_antig_C.
DR   InterPro; IPR022648; Pr_cel_nuc_antig_N.
DR   PANTHER; PTHR11352:SF0; PTHR11352:SF0; 1.
DR   Pfam; PF02747; PCNA_C; 1.
DR   Pfam; PF00705; PCNA_N; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; Reference proteome.
FT   CHAIN           1..256
FT                   /note="DNA polymerase sliding clamp 2"
FT                   /id="PRO_0000149205"
SQ   SEQUENCE   256 AA;  28549 MW;  32A3068F246CEF3E CRC64;
     MSVRALFPKG KEPRYAFEVL IRMLPEAVLN FSSDGISLKA LDPTKTALLD LTFYATALED
     YSIDEETKVG IIFTTIKDVI KRIGATEKLE LEVDKERNRF SFYIYPKKGR EVGLVRRFSF
     PIVQVLEEEI PELAVSFDAS FEIDSAVLDD ILAMVDEVSD WIQITVSPDK VLFRGVGEGG
     KAAETELSYD SESVFNISAG EAASAKYSVE MLRDISGKMK SLSKRVKVEL SANKPIRLTY
     EFTSGVFTAT IAPRVD