PCNA_ARCFU
ID PCNA_ARCFU Reviewed; 245 AA.
AC O29912;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 129.
DE RecName: Full=DNA polymerase sliding clamp {ECO:0000255|HAMAP-Rule:MF_00317};
DE AltName: Full=Proliferating cell nuclear antigen homolog {ECO:0000255|HAMAP-Rule:MF_00317};
DE Short=PCNA {ECO:0000255|HAMAP-Rule:MF_00317};
GN Name=pcn {ECO:0000255|HAMAP-Rule:MF_00317}; OrderedLocusNames=AF_0335;
OS Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC
OS 100126 / VC-16).
OC Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC Archaeoglobus.
OX NCBI_TaxID=224325;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX PubMed=9389475; DOI=10.1038/37052;
RA Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A.,
RA Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L.,
RA Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D.,
RA Quackenbush J., Lee N.H., Sutton G.G., Gill S.R., Kirkness E.F.,
RA Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N.,
RA Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R.,
RA Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D.,
RA Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P.,
RA Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M.,
RA Smith H.O., Woese C.R., Venter J.C.;
RT "The complete genome sequence of the hyperthermophilic, sulphate-reducing
RT archaeon Archaeoglobus fulgidus.";
RL Nature 390:364-370(1997).
CC -!- FUNCTION: Sliding clamp subunit that acts as a moving platform for DNA
CC processing. Responsible for tethering the catalytic subunit of DNA
CC polymerase and other proteins to DNA during high-speed replication.
CC {ECO:0000255|HAMAP-Rule:MF_00317}.
CC -!- SUBUNIT: Homotrimer. The subunits circularize to form a toroid; DNA
CC passes through its center. Replication factor C (RFC) is required to
CC load the toroid on the DNA. {ECO:0000255|HAMAP-Rule:MF_00317}.
CC -!- SIMILARITY: Belongs to the PCNA family. {ECO:0000255|HAMAP-
CC Rule:MF_00317}.
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DR EMBL; AE000782; AAB90899.1; -; Genomic_DNA.
DR PIR; G69291; G69291.
DR RefSeq; WP_010877842.1; NC_000917.1.
DR PDB; 1RWZ; X-ray; 1.80 A; A=1-245.
DR PDB; 1RXM; X-ray; 2.80 A; A=1-245.
DR PDB; 1RXZ; X-ray; 2.00 A; A=1-245.
DR PDB; 3P83; X-ray; 3.05 A; A/B/C=1-245.
DR PDBsum; 1RWZ; -.
DR PDBsum; 1RXM; -.
DR PDBsum; 1RXZ; -.
DR PDBsum; 3P83; -.
DR AlphaFoldDB; O29912; -.
DR SMR; O29912; -.
DR STRING; 224325.AF_0335; -.
DR EnsemblBacteria; AAB90899; AAB90899; AF_0335.
DR GeneID; 24793874; -.
DR KEGG; afu:AF_0335; -.
DR eggNOG; arCOG00488; Archaea.
DR HOGENOM; CLU_043978_1_1_2; -.
DR OMA; EMKLINM; -.
DR OrthoDB; 70433at2157; -.
DR PhylomeDB; O29912; -.
DR BRENDA; 3.1.26.4; 414.
DR EvolutionaryTrace; O29912; -.
DR Proteomes; UP000002199; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030337; F:DNA polymerase processivity factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00317; DNApol_clamp_arch; 1.
DR IDEAL; IID90026; -.
DR InterPro; IPR000730; Pr_cel_nuc_antig.
DR InterPro; IPR022649; Pr_cel_nuc_antig_C.
DR InterPro; IPR022659; Pr_cel_nuc_antig_CS.
DR InterPro; IPR022648; Pr_cel_nuc_antig_N.
DR PANTHER; PTHR11352:SF0; PTHR11352:SF0; 1.
DR Pfam; PF02747; PCNA_C; 1.
DR Pfam; PF00705; PCNA_N; 1.
DR PRINTS; PR00339; PCNACYCLIN.
DR PROSITE; PS01251; PCNA_1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; DNA replication; DNA-binding; Reference proteome.
FT CHAIN 1..245
FT /note="DNA polymerase sliding clamp"
FT /id="PRO_0000149192"
FT STRAND 2..7
FT /evidence="ECO:0007829|PDB:1RWZ"
FT HELIX 8..19
FT /evidence="ECO:0007829|PDB:1RWZ"
FT STRAND 23..30
FT /evidence="ECO:0007829|PDB:1RWZ"
FT STRAND 33..39
FT /evidence="ECO:0007829|PDB:1RWZ"
FT STRAND 43..52
FT /evidence="ECO:0007829|PDB:1RWZ"
FT HELIX 53..55
FT /evidence="ECO:0007829|PDB:1RWZ"
FT STRAND 56..63
FT /evidence="ECO:0007829|PDB:1RWZ"
FT STRAND 65..70
FT /evidence="ECO:0007829|PDB:1RWZ"
FT HELIX 71..78
FT /evidence="ECO:0007829|PDB:1RWZ"
FT STRAND 85..101
FT /evidence="ECO:0007829|PDB:1RWZ"
FT STRAND 104..109
FT /evidence="ECO:0007829|PDB:1RWZ"
FT HELIX 113..115
FT /evidence="ECO:0007829|PDB:1RWZ"
FT STRAND 128..134
FT /evidence="ECO:0007829|PDB:1RWZ"
FT HELIX 135..146
FT /evidence="ECO:0007829|PDB:1RWZ"
FT STRAND 150..157
FT /evidence="ECO:0007829|PDB:1RWZ"
FT STRAND 160..166
FT /evidence="ECO:0007829|PDB:1RWZ"
FT STRAND 171..176
FT /evidence="ECO:0007829|PDB:1RWZ"
FT HELIX 178..180
FT /evidence="ECO:0007829|PDB:1RWZ"
FT STRAND 181..184
FT /evidence="ECO:0007829|PDB:1RWZ"
FT STRAND 189..194
FT /evidence="ECO:0007829|PDB:1RWZ"
FT HELIX 195..201
FT /evidence="ECO:0007829|PDB:1RWZ"
FT HELIX 202..204
FT /evidence="ECO:0007829|PDB:1RWZ"
FT STRAND 210..215
FT /evidence="ECO:0007829|PDB:1RWZ"
FT STRAND 217..219
FT /evidence="ECO:0007829|PDB:1RWZ"
FT STRAND 221..227
FT /evidence="ECO:0007829|PDB:1RWZ"
FT TURN 228..231
FT /evidence="ECO:0007829|PDB:1RWZ"
FT STRAND 232..238
FT /evidence="ECO:0007829|PDB:1RWZ"
FT STRAND 241..243
FT /evidence="ECO:0007829|PDB:1RXZ"
SQ SEQUENCE 245 AA; 27267 MW; 5665CDA0EA393CE3 CRC64;
MIDVIMTGEL LKTVTRAIVA LVSEARIHFL EKGLHSRAVD PANVAMVIVD IPKDSFEVYN
IDEEKTIGVD MDRIFDISKS ISTKDLVELI VEDESTLKVK FGSVEYKVAL IDPSAIRKEP
RIPELELPAK IVMDAGEFKK AIAAADKISD QVIFRSDKEG FRIEAKGDVD SIVFHMTETE
LIEFNGGEAR SMFSVDYLKE FCKVAGSGDL LTIHLGTNYP VRLVFELVGG RAKVEYILAP
RIESE
