ID   PCNA_BOMMO              Reviewed;         260 AA.
AC   O01377;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Proliferating cell nuclear antigen;
DE            Short=PCNA;
DE   AltName: Full=Cyclin;
GN   Name=PCNA;
OS   Bombyx mori (Silk moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Bombycidae; Bombycinae; Bombyx.
OX   NCBI_TaxID=7091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=9498568; DOI=10.1093/oxfordjournals.jbchem.a021884;
RA   Takahashi Y., Yamaguchi M., Hirose F., Kobayashi J., Miyajima S.,
RA   Matsukage A.;
RT   "Involvement of the DNA replication-related element (DRE) and DRE-binding
RT   factor (DREF) in transcriptional regulation of the Bombyx mori PCNA gene.";
RL   J. Biochem. 122:1215-1223(1997).
CC   -!- FUNCTION: This protein is an auxiliary protein of DNA polymerase delta
CC       and is involved in the control of eukaryotic DNA replication by
CC       increasing the polymerase's processibility during elongation of the
CC       leading strand.
CC   -!- SUBUNIT: Homotrimer. Forms a complex with activator 1 heteropentamer in
CC       the presence of ATP (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the PCNA family. {ECO:0000305}.
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DR   EMBL; AB002264; BAA19522.1; -; mRNA.
DR   EMBL; AB002265; BAA19523.1; -; Genomic_DNA.
DR   PIR; JC5890; JC5890.
DR   RefSeq; NP_001036825.1; NM_001043360.1.
DR   AlphaFoldDB; O01377; -.
DR   SMR; O01377; -.
DR   STRING; 7091.BGIBMGA010906-TA; -.
DR   GeneID; 692356; -.
DR   KEGG; bmor:692356; -.
DR   CTD; 5111; -.
DR   eggNOG; KOG1636; Eukaryota.
DR   HOGENOM; CLU_043978_3_0_1; -.
DR   InParanoid; O01377; -.
DR   OrthoDB; 1012066at2759; -.
DR   Proteomes; UP000005204; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030337; F:DNA polymerase processivity factor activity; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   HAMAP; MF_00317; DNApol_clamp_arch; 1.
DR   InterPro; IPR000730; Pr_cel_nuc_antig.
DR   InterPro; IPR022649; Pr_cel_nuc_antig_C.
DR   InterPro; IPR022659; Pr_cel_nuc_antig_CS.
DR   InterPro; IPR022648; Pr_cel_nuc_antig_N.
DR   Pfam; PF02747; PCNA_C; 1.
DR   Pfam; PF00705; PCNA_N; 1.
DR   PRINTS; PR00339; PCNACYCLIN.
DR   TIGRFAMs; TIGR00590; pcna; 1.
DR   PROSITE; PS01251; PCNA_1; 1.
DR   PROSITE; PS00293; PCNA_2; 1.
PE   2: Evidence at transcript level;
KW   DNA replication; DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..260
FT                   /note="Proliferating cell nuclear antigen"
FT                   /id="PRO_0000149169"
FT   DNA_BIND        61..80
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   260 AA;  29036 MW;  EA82AF2B20C4CA48 CRC64;
     MFEARLLRSS ILKKVLEAIK DLLTQATFDC DDNGIQLQAM DNSHVSLVSL TLRADGFDKY
     RCDRNISMGM NLGSMSKILI FAGDKDTATI KAQDNADNVT FVFESPNQEK VSDYEMKLMN
     LDLEHLGIPE TEYSCTIRMP SSEFARICRD LSQFGESMVI SCTKEGVKFS ATGDIGSANV
     KLAQTASIDK EEEAVVIEME EPVTLTFACQ YLNYFTKATS LSPQVQLSMS ADVPLVVEYR
     IPDIGHIRYY LAPKIEEEDS