ID   PCNA_CAEEL              Reviewed;         263 AA.
AC   O02115;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 3.
DT   03-AUG-2022, entry version 158.
DE   RecName: Full=Proliferating cell nuclear antigen;
DE            Short=PCNA;
GN   Name=pcn-1; ORFNames=W03D2.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: This protein is an auxiliary protein of DNA polymerase delta
CC       and is involved in the control of eukaryotic DNA replication by
CC       increasing the polymerase's processibility during elongation of the
CC       leading strand. {ECO:0000250}.
CC   -!- SUBUNIT: Homotrimer. Forms a complex with activator 1 heteropentamer in
CC       the presence of ATP (By similarity). {ECO:0000250}.
CC   -!- INTERACTION:
CC       O02115; G5EC44: mrt-2; NbExp=3; IntAct=EBI-318162, EBI-323732;
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the PCNA family. {ECO:0000305}.
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DR   EMBL; FO080786; CCD66765.1; -; Genomic_DNA.
DR   PIR; T28761; T28761.
DR   RefSeq; NP_500466.3; NM_068065.6.
DR   AlphaFoldDB; O02115; -.
DR   SMR; O02115; -.
DR   BioGRID; 42297; 27.
DR   ComplexPortal; CPX-3721; PCNA homotrimer.
DR   DIP; DIP-25347N; -.
DR   IntAct; O02115; 12.
DR   MINT; O02115; -.
DR   STRING; 6239.W03D2.4; -.
DR   EPD; O02115; -.
DR   PaxDb; O02115; -.
DR   PeptideAtlas; O02115; -.
DR   EnsemblMetazoa; W03D2.4.1; W03D2.4.1; WBGene00003955.
DR   GeneID; 177161; -.
DR   KEGG; cel:CELE_W03D2.4; -.
DR   UCSC; W03D2.4.1; c. elegans.
DR   CTD; 177161; -.
DR   WormBase; W03D2.4; CE14512; WBGene00003955; pcn-1.
DR   eggNOG; KOG1636; Eukaryota.
DR   GeneTree; ENSGT00390000004965; -.
DR   HOGENOM; CLU_043978_3_0_1; -.
DR   InParanoid; O02115; -.
DR   OMA; EMKLINM; -.
DR   OrthoDB; 1012066at2759; -.
DR   PhylomeDB; O02115; -.
DR   Reactome; R-CEL-110312; Translesion synthesis by REV1.
DR   Reactome; R-CEL-110314; Recognition of DNA damage by PCNA-containing replication complex.
DR   Reactome; R-CEL-110320; Translesion Synthesis by POLH.
DR   Reactome; R-CEL-4615885; SUMOylation of DNA replication proteins.
DR   Reactome; R-CEL-5358565; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).
DR   Reactome; R-CEL-5651801; PCNA-Dependent Long Patch Base Excision Repair.
DR   Reactome; R-CEL-5655862; Translesion synthesis by POLK.
DR   Reactome; R-CEL-5656169; Termination of translesion DNA synthesis.
DR   Reactome; R-CEL-5696397; Gap-filling DNA repair synthesis and ligation in GG-NER.
DR   Reactome; R-CEL-5696400; Dual Incision in GG-NER.
DR   Reactome; R-CEL-6782135; Dual incision in TC-NER.
DR   Reactome; R-CEL-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER.
DR   Reactome; R-CEL-69091; Polymerase switching.
DR   Reactome; R-CEL-69166; Removal of the Flap Intermediate.
DR   Reactome; R-CEL-69183; Processive synthesis on the lagging strand.
DR   SignaLink; O02115; -.
DR   PRO; PR:O02115; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00003955; Expressed in embryo and 4 other tissues.
DR   GO; GO:0005634; C:nucleus; IDA:ComplexPortal.
DR   GO; GO:0043626; C:PCNA complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0070182; F:DNA polymerase binding; IPI:WormBase.
DR   GO; GO:0030337; F:DNA polymerase processivity factor activity; IBA:GO_Central.
DR   GO; GO:0006272; P:leading strand elongation; IBA:GO_Central.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   GO; GO:0045739; P:positive regulation of DNA repair; IMP:ComplexPortal.
DR   GO; GO:0045740; P:positive regulation of DNA replication; IMP:ComplexPortal.
DR   GO; GO:0019985; P:translesion synthesis; IBA:GO_Central.
DR   HAMAP; MF_00317; DNApol_clamp_arch; 1.
DR   InterPro; IPR000730; Pr_cel_nuc_antig.
DR   InterPro; IPR022649; Pr_cel_nuc_antig_C.
DR   InterPro; IPR022659; Pr_cel_nuc_antig_CS.
DR   InterPro; IPR022648; Pr_cel_nuc_antig_N.
DR   PANTHER; PTHR11352:SF0; PTHR11352:SF0; 1.
DR   Pfam; PF02747; PCNA_C; 1.
DR   Pfam; PF00705; PCNA_N; 1.
DR   PRINTS; PR00339; PCNACYCLIN.
DR   TIGRFAMs; TIGR00590; pcna; 1.
DR   PROSITE; PS01251; PCNA_1; 1.
PE   1: Evidence at protein level;
KW   DNA replication; DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..263
FT                   /note="Proliferating cell nuclear antigen"
FT                   /id="PRO_0000149168"
FT   DNA_BIND        61..80
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   263 AA;  29036 MW;  ED56F971AC68471C CRC64;
     MFEAKLANAG LLKKIVESIK DLVTDAPFDC SETAMSLQAM DSSHVALVSL KLEVGLFDTY
     RCDRTINLGL SLANMSKALK CANNDDTCML KYEENEGDSI IFTFADPKRD KTQDVTVKMM
     DIDSEHLGIP DQDYAVVCEM PAGEFQKTCK DLSTFSDSLN ITATKAGIVF TGKGDIGSSV
     VTYSPSSNTD DETEAVTLEV KDPVNVNFSI KYMNQFTKAT ALSDRVRLSL CNDVPVVVEY
     PIEENGYLRF YLAPKIDDDE NMD