ID   PCNA_CATRO              Reviewed;         268 AA.
AC   P24314;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Proliferating cell nuclear antigen;
DE            Short=PCNA;
DE   AltName: Full=Cyclin;
OS   Catharanthus roseus (Madagascar periwinkle) (Vinca rosea).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Gentianales; Apocynaceae; Rauvolfioideae; Vinceae;
OC   Catharanthinae; Catharanthus.
OX   NCBI_TaxID=4058;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1902790; DOI=10.1111/j.1432-1033.1991.tb15937.x;
RA   Kodama H., Ito M., Ohnishi N., Suzuka I., Komamine A.;
RT   "Molecular cloning of the gene for plant proliferating-cell nuclear antigen
RT   and expression of this gene during the cell cycle in synchronized cultures
RT   of Catharanthus roseus cells.";
RL   Eur. J. Biochem. 197:495-503(1991).
CC   -!- FUNCTION: This protein is an auxiliary protein of DNA polymerase delta
CC       and is involved in the control of eukaryotic DNA replication by
CC       increasing the polymerase's processibility during elongation of the
CC       leading strand.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the PCNA family. {ECO:0000305}.
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DR   EMBL; X55052; CAA38893.1; -; mRNA.
DR   PIR; S15434; S15434.
DR   AlphaFoldDB; P24314; -.
DR   SMR; P24314; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030337; F:DNA polymerase processivity factor activity; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   HAMAP; MF_00317; DNApol_clamp_arch; 1.
DR   InterPro; IPR000730; Pr_cel_nuc_antig.
DR   InterPro; IPR022649; Pr_cel_nuc_antig_C.
DR   InterPro; IPR022659; Pr_cel_nuc_antig_CS.
DR   InterPro; IPR022648; Pr_cel_nuc_antig_N.
DR   Pfam; PF02747; PCNA_C; 1.
DR   Pfam; PF00705; PCNA_N; 1.
DR   PRINTS; PR00339; PCNACYCLIN.
DR   TIGRFAMs; TIGR00590; pcna; 1.
DR   PROSITE; PS01251; PCNA_1; 1.
DR   PROSITE; PS00293; PCNA_2; 1.
PE   2: Evidence at transcript level;
KW   DNA replication; DNA-binding; Nucleus.
FT   CHAIN           1..268
FT                   /note="Proliferating cell nuclear antigen"
FT                   /id="PRO_0000149180"
FT   DNA_BIND        61..80
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   268 AA;  29765 MW;  6CF394C4BA729498 CRC64;
     MLELRLVQGS LLKKVLESLK DLVTDANFDC SASGFSLQAM DSSHVALVAL LLRSEGFEHY
     RCDRNPSMGM NLNNMAKMLK CAGNDDIITL KADDGSDTVT FMFESPTQDK ISDFEMKLMD
     IDSEHLGIPE AEYHAIVRMP SAEFARICKD LSSIGDTVVI SVTKEGVKFS TRGDIGTANI
     VCRQNTTVDK PDEATIIEMN EPVSLTFALR YLNSFTKATP LSNNVTISLS SELPVVVEYK
     IAEMGYIRFY LAPKIEEDDE EQSLEYQA