ID   PCNA_DICDI              Reviewed;         258 AA.
AC   Q54K47;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Proliferating cell nuclear antigen;
DE            Short=PCNA;
GN   Name=pcna; ORFNames=DDB_G0287607;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: This protein is an auxiliary protein of DNA polymerase delta
CC       and is involved in the control of eukaryotic DNA replication by
CC       increasing the polymerase's processibility during elongation of the
CC       leading strand. {ECO:0000250}.
CC   -!- SUBUNIT: Homotrimer. Forms a complex with activator 1 heteropentamer in
CC       the presence of ATP (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PCNA family. {ECO:0000305}.
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DR   EMBL; AAFI02000103; EAL63612.1; -; Genomic_DNA.
DR   RefSeq; XP_637117.1; XM_632025.1.
DR   AlphaFoldDB; Q54K47; -.
DR   SMR; Q54K47; -.
DR   STRING; 44689.DDB0231779; -.
DR   PaxDb; Q54K47; -.
DR   EnsemblProtists; EAL63612; EAL63612; DDB_G0287607.
DR   GeneID; 8626212; -.
DR   KEGG; ddi:DDB_G0287607; -.
DR   dictyBase; DDB_G0287607; pcna.
DR   eggNOG; KOG1636; Eukaryota.
DR   HOGENOM; CLU_043978_3_0_1; -.
DR   InParanoid; Q54K47; -.
DR   OMA; EMKLINM; -.
DR   PhylomeDB; Q54K47; -.
DR   Reactome; R-DDI-4615885; SUMOylation of DNA replication proteins.
DR   Reactome; R-DDI-5358565; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).
DR   Reactome; R-DDI-5656169; Termination of translesion DNA synthesis.
DR   Reactome; R-DDI-6782135; Dual incision in TC-NER.
DR   Reactome; R-DDI-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER.
DR   Reactome; R-DDI-69091; Polymerase switching.
DR   Reactome; R-DDI-69166; Removal of the Flap Intermediate.
DR   Reactome; R-DDI-69183; Processive synthesis on the lagging strand.
DR   Reactome; R-DDI-8866654; E3 ubiquitin ligases ubiquitinate target proteins.
DR   PRO; PR:Q54K47; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005634; C:nucleus; IDA:dictyBase.
DR   GO; GO:0043626; C:PCNA complex; ISS:dictyBase.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030337; F:DNA polymerase processivity factor activity; ISS:dictyBase.
DR   GO; GO:0006273; P:lagging strand elongation; ISS:dictyBase.
DR   GO; GO:0006272; P:leading strand elongation; ISS:dictyBase.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   GO; GO:0019985; P:translesion synthesis; IBA:GO_Central.
DR   HAMAP; MF_00317; DNApol_clamp_arch; 1.
DR   InterPro; IPR000730; Pr_cel_nuc_antig.
DR   InterPro; IPR022649; Pr_cel_nuc_antig_C.
DR   InterPro; IPR022648; Pr_cel_nuc_antig_N.
DR   PANTHER; PTHR11352:SF0; PTHR11352:SF0; 1.
DR   Pfam; PF02747; PCNA_C; 1.
DR   Pfam; PF00705; PCNA_N; 1.
DR   PRINTS; PR00339; PCNACYCLIN.
DR   TIGRFAMs; TIGR00590; pcna; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..258
FT                   /note="Proliferating cell nuclear antigen"
FT                   /id="PRO_0000329023"
FT   DNA_BIND        61..80
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   258 AA;  28314 MW;  C0F9268702D95F51 CRC64;
     MFEARLLQAS LLKKILESIK DLVESANFDC SPEGISLQAM DGTHVTLINL VLRNEGFETY
     NCDRSLSLGL SLVSLSKILK CAGNDDTLTI RARDNESDTV TFVFESPKND RVSDFEIKLI
     DIKNEQYSIR KSDYSAVIKM PSAELQRICR DLSIIGEIVT ISANKEGVKF SVSGDSGSGN
     ITIKPTSDSD VPAEQATVIE SKEPVVLNFA LKFLSNFTKA TPLSPMVTLS MSEGIPVVVE
     YKIDDLGFLG FFLAPKIE