ID   PCNA_HALSA              Reviewed;         247 AA.
AC   Q9HN45;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2001, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=DNA polymerase sliding clamp {ECO:0000255|HAMAP-Rule:MF_00317};
DE   AltName: Full=Proliferating cell nuclear antigen homolog {ECO:0000255|HAMAP-Rule:MF_00317};
DE            Short=PCNA {ECO:0000255|HAMAP-Rule:MF_00317};
GN   Name=pcn {ECO:0000255|HAMAP-Rule:MF_00317}; OrderedLocusNames=VNG_2256G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
CC   -!- FUNCTION: Sliding clamp subunit that acts as a moving platform for DNA
CC       processing. Responsible for tethering the catalytic subunit of DNA
CC       polymerase and other proteins to DNA during high-speed replication.
CC       {ECO:0000255|HAMAP-Rule:MF_00317}.
CC   -!- SUBUNIT: Homotrimer. The subunits circularize to form a toroid; DNA
CC       passes through its center. Replication factor C (RFC) is required to
CC       load the toroid on the DNA. {ECO:0000255|HAMAP-Rule:MF_00317}.
CC   -!- SIMILARITY: Belongs to the PCNA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00317}.
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DR   EMBL; AE004437; AAG20376.1; -; Genomic_DNA.
DR   PIR; D84376; D84376.
DR   RefSeq; WP_010903677.1; NC_002607.1.
DR   AlphaFoldDB; Q9HN45; -.
DR   SMR; Q9HN45; -.
DR   STRING; 64091.VNG_2256G; -.
DR   PaxDb; Q9HN45; -.
DR   EnsemblBacteria; AAG20376; AAG20376; VNG_2256G.
DR   GeneID; 5953309; -.
DR   GeneID; 62887537; -.
DR   KEGG; hal:VNG_2256G; -.
DR   PATRIC; fig|64091.14.peg.1736; -.
DR   HOGENOM; CLU_043978_1_1_2; -.
DR   InParanoid; Q9HN45; -.
DR   OMA; EMKLINM; -.
DR   OrthoDB; 70433at2157; -.
DR   PhylomeDB; Q9HN45; -.
DR   Proteomes; UP000000554; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030337; F:DNA polymerase processivity factor activity; IBA:GO_Central.
DR   GO; GO:0006272; P:leading strand elongation; IBA:GO_Central.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00317; DNApol_clamp_arch; 1.
DR   InterPro; IPR000730; Pr_cel_nuc_antig.
DR   InterPro; IPR022649; Pr_cel_nuc_antig_C.
DR   InterPro; IPR022659; Pr_cel_nuc_antig_CS.
DR   InterPro; IPR022648; Pr_cel_nuc_antig_N.
DR   PANTHER; PTHR11352:SF0; PTHR11352:SF0; 1.
DR   Pfam; PF02747; PCNA_C; 1.
DR   Pfam; PF00705; PCNA_N; 1.
DR   PRINTS; PR00339; PCNACYCLIN.
DR   PROSITE; PS01251; PCNA_1; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; Reference proteome.
FT   CHAIN           1..247
FT                   /note="DNA polymerase sliding clamp"
FT                   /id="PRO_0000149194"
SQ   SEQUENCE   247 AA;  26824 MW;  B1506BBD54851544 CRC64;
     MFKAIVSADT LQETLDSVSV LVDECKIHLD DDTLSIRAVD PASVGMVDLD LAATAFESYE
     ADGGLIGVNL SRLEDIAGMA DAGQLIQLEL DEETRKLHIQ IDGLEYTLAL IDPDSIRQEP
     DIPDLDLPAH VAIEGRDIDR AVTAADMVSD HIALGVDTGD DLFYVNAEGD TDDVHLELAP
     DQLIDLDAGD AHSLFSLDYL KDMNKAIPTT AEVELELGDE FPIKLHFDIA DAQGHVTYML
     APRIQSN