ID   PCNA_HAPBU              Reviewed;         260 AA.
AC   Q6B6N4;
DT   24-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Proliferating cell nuclear antigen;
DE            Short=PCNA;
GN   Name=pcna;
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Retina;
RA   Zhao S., Fernald R.D.;
RT   "Establishment of a novel auto-regression algorithm for directly computing
RT   efficiency from individual reaction provides sensitive, accurate, and
RT   platform independent analysis for real-time PCR.";
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is an auxiliary protein of DNA polymerase delta
CC       and is involved in the control of eukaryotic DNA replication by
CC       increasing the polymerase's processibility during elongation of the
CC       leading strand. {ECO:0000250}.
CC   -!- SUBUNIT: Homotrimer. Forms a complex with activator 1 heteropentamer in
CC       the presence of ATP (By similarity). Component of the replisome complex
CC       (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P12004}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P12004}.
CC   -!- PTM: Monoubiquitinated by the ube2b-rad18 complex on Lys-164.
CC       Monoubiquitination at Lys-164 also takes place in undamaged
CC       proliferating cells, and is mediated by the dcx(dtl) complex, leading
CC       to enhance PCNA-dependent translesion DNA synthesis (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PCNA family. {ECO:0000305}.
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DR   EMBL; AY677117; AAT78432.1; -; mRNA.
DR   RefSeq; NP_001273253.1; NM_001286324.1.
DR   AlphaFoldDB; Q6B6N4; -.
DR   SMR; Q6B6N4; -.
DR   STRING; 8153.XP_005924403.1; -.
DR   Ensembl; ENSHBUT00000020260; ENSHBUP00000029821; ENSHBUG00000000420.
DR   GeneID; 102307523; -.
DR   CTD; 5111; -.
DR   GeneTree; ENSGT00390000004965; -.
DR   OMA; EMKLINM; -.
DR   OrthoDB; 1012066at2759; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0070557; C:PCNA-p21 complex; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030337; F:DNA polymerase processivity factor activity; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   GO; GO:0014823; P:response to activity; IEA:Ensembl.
DR   GO; GO:0009617; P:response to bacterium; IEA:Ensembl.
DR   GO; GO:0019985; P:translesion synthesis; ISS:UniProtKB.
DR   HAMAP; MF_00317; DNApol_clamp_arch; 1.
DR   InterPro; IPR000730; Pr_cel_nuc_antig.
DR   InterPro; IPR022649; Pr_cel_nuc_antig_C.
DR   InterPro; IPR022659; Pr_cel_nuc_antig_CS.
DR   InterPro; IPR022648; Pr_cel_nuc_antig_N.
DR   Pfam; PF02747; PCNA_C; 1.
DR   Pfam; PF00705; PCNA_N; 1.
DR   PRINTS; PR00339; PCNACYCLIN.
DR   TIGRFAMs; TIGR00590; pcna; 1.
DR   PROSITE; PS01251; PCNA_1; 1.
DR   PROSITE; PS00293; PCNA_2; 1.
PE   2: Evidence at transcript level;
KW   DNA replication; DNA-binding; Isopeptide bond; Nucleus; Reference proteome;
KW   Ubl conjugation.
FT   CHAIN           1..260
FT                   /note="Proliferating cell nuclear antigen"
FT                   /id="PRO_0000149166"
FT   DNA_BIND        61..80
FT                   /evidence="ECO:0000255"
FT   CROSSLNK        164
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in ubiquitin)"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   260 AA;  28689 MW;  A9701765B59532E6 CRC64;
     MFEARLVQGS ILKKVLEALK DLITEACWDV SSSGISLQSM DSSHVSLVQL TLRHDGFDSY
     RCDRNLAMGV NLSSMSKILK CAGNEDIITL RAEDNADTLA LVFETLNQEK VSDYEMKLMD
     LDVEQLGIPE QEYSCVVKMP SGEFARICRD LSQIGDAVMI SCAKDGVKFS ASGELGTGNI
     KLSQTSNVDK EDEAVTIEMN EPVQLIFALN YLNFFTKATP LSKTVTLSMS ADIPLVVEYK
     IADMGHIKYY LAPKIDEEAS