ID   PCNA_METKA              Reviewed;         253 AA.
AC   Q8TWK3;
DT   10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=DNA polymerase sliding clamp {ECO:0000255|HAMAP-Rule:MF_00317};
DE   AltName: Full=Proliferating cell nuclear antigen homolog {ECO:0000255|HAMAP-Rule:MF_00317};
DE            Short=PCNA {ECO:0000255|HAMAP-Rule:MF_00317};
GN   Name=pcn {ECO:0000255|HAMAP-Rule:MF_00317}; OrderedLocusNames=MK1030;
OS   Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938).
OC   Archaea; Euryarchaeota; Methanopyri; Methanopyrales; Methanopyraceae;
OC   Methanopyrus.
OX   NCBI_TaxID=190192;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AV19 / DSM 6324 / JCM 9639 / NBRC 100938;
RX   PubMed=11930014; DOI=10.1073/pnas.032671499;
RA   Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N.,
RA   Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L., Natale D.A.,
RA   Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O., Malykh A.G.,
RA   Koonin E.V., Kozyavkin S.A.;
RT   "The complete genome of hyperthermophile Methanopyrus kandleri AV19 and
RT   monophyly of archaeal methanogens.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002).
CC   -!- FUNCTION: Sliding clamp subunit that acts as a moving platform for DNA
CC       processing. Responsible for tethering the catalytic subunit of DNA
CC       polymerase and other proteins to DNA during high-speed replication.
CC       {ECO:0000255|HAMAP-Rule:MF_00317}.
CC   -!- SUBUNIT: Homotrimer. The subunits circularize to form a toroid; DNA
CC       passes through its center. Replication factor C (RFC) is required to
CC       load the toroid on the DNA. {ECO:0000255|HAMAP-Rule:MF_00317}.
CC   -!- SIMILARITY: Belongs to the PCNA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00317}.
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DR   EMBL; AE009439; AAM02243.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8TWK3; -.
DR   SMR; Q8TWK3; -.
DR   STRING; 190192.MK1030; -.
DR   EnsemblBacteria; AAM02243; AAM02243; MK1030.
DR   KEGG; mka:MK1030; -.
DR   HOGENOM; CLU_043978_1_0_2; -.
DR   OMA; EMKLINM; -.
DR   Proteomes; UP000001826; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030337; F:DNA polymerase processivity factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00317; DNApol_clamp_arch; 1.
DR   InterPro; IPR000730; Pr_cel_nuc_antig.
DR   InterPro; IPR022649; Pr_cel_nuc_antig_C.
DR   InterPro; IPR022659; Pr_cel_nuc_antig_CS.
DR   InterPro; IPR022648; Pr_cel_nuc_antig_N.
DR   PANTHER; PTHR11352:SF0; PTHR11352:SF0; 1.
DR   Pfam; PF02747; PCNA_C; 1.
DR   Pfam; PF00705; PCNA_N; 1.
DR   PRINTS; PR00339; PCNACYCLIN.
DR   TIGRFAMs; TIGR00590; pcna; 1.
DR   PROSITE; PS01251; PCNA_1; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; Reference proteome.
FT   CHAIN           1..253
FT                   /note="DNA polymerase sliding clamp"
FT                   /id="PRO_0000149197"
SQ   SEQUENCE   253 AA;  28625 MW;  E96FE8AC9C7A3665 CRC64;
     MVEFRAYQEE ARYFKYAFNA AGKVVEEAPL IVTENGIVSR AMDASHIAMA VLEMPWEMFD
     EYEPPSDELM YGLDMEEVTR IVRRARVTDE ITLEGEDEEE VIIKLGSSGY EREFRLRSID
     IDDIPDEPEL DFAVEVTVVP DFIQDAVRDA DLVSDTVKVG AKGNTFYFKA EGERGRVIPK
     VQEGAEALLT FEVEEDVETA YPLDYLKDMI QAAQGAESVR IRLGQDMPLE LTFRIGPAGE
     GKLTFYLAPR VEE