PCNA_METMP
ID PCNA_METMP Reviewed; 250 AA.
AC Q6LWJ8;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=DNA polymerase sliding clamp {ECO:0000255|HAMAP-Rule:MF_00317};
DE AltName: Full=Proliferating cell nuclear antigen homolog {ECO:0000255|HAMAP-Rule:MF_00317};
DE Short=PCNA {ECO:0000255|HAMAP-Rule:MF_00317};
GN Name=pcn {ECO:0000255|HAMAP-Rule:MF_00317}; OrderedLocusNames=MMP1711;
OS Methanococcus maripaludis (strain S2 / LL).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanococcaceae; Methanococcus.
OX NCBI_TaxID=267377;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S2 / LL;
RX PubMed=15466049; DOI=10.1128/jb.186.20.6956-6969.2004;
RA Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J.,
RA Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M.,
RA Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A.,
RA Moore B.C., Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soell D.,
RA Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W.,
RA Olson M.V., Leigh J.A.;
RT "Complete genome sequence of the genetically tractable hydrogenotrophic
RT methanogen Methanococcus maripaludis.";
RL J. Bacteriol. 186:6956-6969(2004).
CC -!- FUNCTION: Sliding clamp subunit that acts as a moving platform for DNA
CC processing. Responsible for tethering the catalytic subunit of DNA
CC polymerase and other proteins to DNA during high-speed replication.
CC {ECO:0000255|HAMAP-Rule:MF_00317}.
CC -!- SUBUNIT: Homotrimer. The subunits circularize to form a toroid; DNA
CC passes through its center. Replication factor C (RFC) is required to
CC load the toroid on the DNA. {ECO:0000255|HAMAP-Rule:MF_00317}.
CC -!- SIMILARITY: Belongs to the PCNA family. {ECO:0000255|HAMAP-
CC Rule:MF_00317}.
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DR EMBL; BX950229; CAF31267.1; -; Genomic_DNA.
DR RefSeq; WP_011171655.1; NC_005791.1.
DR AlphaFoldDB; Q6LWJ8; -.
DR SMR; Q6LWJ8; -.
DR STRING; 267377.MMP1711; -.
DR EnsemblBacteria; CAF31267; CAF31267; MMP1711.
DR GeneID; 36102204; -.
DR KEGG; mmp:MMP1711; -.
DR PATRIC; fig|267377.15.peg.1754; -.
DR eggNOG; arCOG00488; Archaea.
DR HOGENOM; CLU_043978_1_0_2; -.
DR OMA; EMKLINM; -.
DR OrthoDB; 70433at2157; -.
DR BioCyc; MMAR267377:MMP_RS08810-MON; -.
DR Proteomes; UP000000590; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030337; F:DNA polymerase processivity factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00317; DNApol_clamp_arch; 1.
DR InterPro; IPR000730; Pr_cel_nuc_antig.
DR InterPro; IPR022649; Pr_cel_nuc_antig_C.
DR InterPro; IPR022659; Pr_cel_nuc_antig_CS.
DR InterPro; IPR022648; Pr_cel_nuc_antig_N.
DR PANTHER; PTHR11352:SF0; PTHR11352:SF0; 1.
DR Pfam; PF02747; PCNA_C; 1.
DR Pfam; PF00705; PCNA_N; 1.
DR PRINTS; PR00339; PCNACYCLIN.
DR TIGRFAMs; TIGR00590; pcna; 1.
DR PROSITE; PS01251; PCNA_1; 1.
PE 3: Inferred from homology;
KW DNA replication; DNA-binding; Reference proteome.
FT CHAIN 1..250
FT /note="DNA polymerase sliding clamp"
FT /id="PRO_0000149199"
SQ SEQUENCE 250 AA; 27871 MW; 5EAF4FE174158A21 CRC64;
MFRATCNTRD FKKVINATSN LVDEICFEVD ENGIKASAMD PSHVALVSME MPKDVFEEYE
GDIQDIGIDL EALKKIIARG RGDEKLILDL DVEKNKLNIT FKSNVTRKFS IALYDVSSSN
LKVPDIEYPN SVSIKAGAFV EALKDAELVN DHITLKIDEN KFVIYSKGDL NQSETVFDNS
IDDDDNALAD FNMGEASRST FNLAYLKDLT KSTAAEDLLK IYLGSDMPVK IEYEVSGSKL
VFLLAPRIES