ID   PCNA_METTH              Reviewed;         244 AA.
AC   O27367;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 121.
DE   RecName: Full=DNA polymerase sliding clamp {ECO:0000255|HAMAP-Rule:MF_00317};
DE   AltName: Full=Proliferating cell nuclear antigen homolog {ECO:0000255|HAMAP-Rule:MF_00317};
DE            Short=PCNA {ECO:0000255|HAMAP-Rule:MF_00317};
GN   Name=pcn {ECO:0000255|HAMAP-Rule:MF_00317}; OrderedLocusNames=MTH_1312;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
RN   [2]
RP   FUNCTION.
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=10497247; DOI=10.1074/jbc.274.40.28751;
RA   Kelman Z., Pietrokovski S., Hurwitz J.;
RT   "Isolation and characterization of a split B-type DNA polymerase from the
RT   archaeon Methanobacterium thermoautotrophicum deltaH.";
RL   J. Biol. Chem. 274:28751-28761(1999).
CC   -!- FUNCTION: Sliding clamp subunit that acts as a moving platform for DNA
CC       processing. Responsible for tethering the catalytic subunit of DNA
CC       polymerase to DNA during high-speed replication (By similarity). In
CC       conjunction with replication factor C (RFC) stimulates DNA synthesis by
CC       PolB, relieving inhibition by replication protein A (RPA).
CC       {ECO:0000250, ECO:0000269|PubMed:10497247}.
CC   -!- SUBUNIT: Homotrimer. The subunits circularize to form a toroid; DNA
CC       passes through its center. Replication factor C (RFC) is required to
CC       load the toroid on the DNA. {ECO:0000255|HAMAP-Rule:MF_00317}.
CC   -!- SIMILARITY: Belongs to the PCNA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00317}.
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DR   EMBL; AE000666; AAB85790.1; -; Genomic_DNA.
DR   PIR; D69041; D69041.
DR   RefSeq; WP_010876925.1; NC_000916.1.
DR   AlphaFoldDB; O27367; -.
DR   SMR; O27367; -.
DR   STRING; 187420.MTH_1312; -.
DR   EnsemblBacteria; AAB85790; AAB85790; MTH_1312.
DR   GeneID; 1471029; -.
DR   KEGG; mth:MTH_1312; -.
DR   PATRIC; fig|187420.15.peg.1281; -.
DR   HOGENOM; CLU_043978_1_1_2; -.
DR   OMA; EMKLINM; -.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030337; F:DNA polymerase processivity factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00317; DNApol_clamp_arch; 1.
DR   InterPro; IPR000730; Pr_cel_nuc_antig.
DR   InterPro; IPR022659; Pr_cel_nuc_antig_CS.
DR   InterPro; IPR022648; Pr_cel_nuc_antig_N.
DR   PANTHER; PTHR11352:SF0; PTHR11352:SF0; 1.
DR   Pfam; PF00705; PCNA_N; 1.
DR   PRINTS; PR00339; PCNACYCLIN.
DR   TIGRFAMs; TIGR00590; pcna; 1.
DR   PROSITE; PS01251; PCNA_1; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; Reference proteome.
FT   CHAIN           1..244
FT                   /note="DNA polymerase sliding clamp"
FT                   /id="PRO_0000149200"
SQ   SEQUENCE   244 AA;  27969 MW;  CCE44AAE59139CB7 CRC64;
     MFKAELNDPN ILRTSFDAIS SIVDEVQIQL SAEGLRLDAL DRSHITYVHL ELKAELFDEY
     VCDEPERINV DTEELMKVLK RAKANDRVIL STDEGNLIIQ FEGEAVRTFK IRLIDIEYET
     PSPPEIEYEN EFEVPFQLLK DSIADIDIFS DKITFRVDED RFIASAEGEF GDAQIEYLHG
     ERIDKPARSI YSLDKIKEML KADKFSETAI INLGDDMPLK LTLKMASKEG ELSFLLAPRI
     EAEE