PCNA_NPVAC
ID PCNA_NPVAC Reviewed; 256 AA.
AC P11038;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 1.
DT 29-SEP-2021, entry version 88.
DE RecName: Full=Probable DNA polymerase sliding clamp;
DE AltName: Full=EcoRI-T site protein ETL;
DE AltName: Full=Proliferating cell nuclear antigen homolog;
DE Short=PCNA;
GN Name=PCNA; ORFNames=ORF49;
OS Autographa californica nuclear polyhedrosis virus (AcMNPV).
OC Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX NCBI_TaxID=46015;
OH NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=L1;
RX PubMed=3292791; DOI=10.1128/jvi.62.8.2773-2781.1988;
RA Crawford A., Miller L.K.;
RT "Characterization of an early gene accelerating expression of late genes of
RT the baculovirus Autographa californica nuclear polyhedrosis virus.";
RL J. Virol. 62:2773-2781(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C6;
RX PubMed=8030224; DOI=10.1006/viro.1994.1380;
RA Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.;
RT "The complete DNA sequence of Autographa californica nuclear polyhedrosis
RT virus.";
RL Virology 202:586-605(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-126.
RC STRAIN=L1;
RX PubMed=8207843; DOI=10.1128/jvi.68.7.4673-4678.1994;
RA Passarelli A.L., Todd J.W., Miller L.K.;
RT "A baculovirus gene involved in late gene expression predicts a large
RT polypeptide with a conserved motif of RNA polymerases.";
RL J. Virol. 68:4673-4678(1994).
RN [4]
RP SIMILARITY TO PCNA, AND FUNCTION.
RX PubMed=2563897; DOI=10.1038/337606a0;
RA O'Reilly D.R., Crawford A.M., Miller L.K.;
RT "Viral proliferating cell nuclear antigen.";
RL Nature 337:606-606(1989).
RN [5]
RP FUNCTION.
RX PubMed=15448347; DOI=10.1099/vir.0.80114-0;
RA Iwahori S., Ikeda M., Kobayashi M.;
RT "Association of Sf9 cell proliferating cell nuclear antigen with the DNA
RT replication site of Autographa californica multicapsid
RT nucleopolyhedrovirus.";
RL J. Gen. Virol. 85:2857-2862(2004).
RN [6]
RP FUNCTION.
RX PubMed=29075988; DOI=10.1007/s11010-017-3210-y;
RA Fu Y., Wang R., Liang A.;
RT "Function analysis of Ac-PCNA and Sf-PCNA during the Autographa californica
RT multiple nucleopolyhedrovirus infection process.";
RL Mol. Cell. Biochem. 443:57-68(2018).
CC -!- FUNCTION: Stimulates the viral DNA replication. The virus utilizes both
CC cellular and viral PCNAs during viral DNA replication in order to
CC produce budded virus (BV). In addition, stimulates the expression of
CC late genes 38K and VP39 by promoting the transcription of IE2.
CC {ECO:0000269|PubMed:15448347, ECO:0000269|PubMed:2563897,
CC ECO:0000269|PubMed:29075988}.
CC -!- DEVELOPMENTAL STAGE: Transcribed early (from 2 through 6 hours post-
CC infection) but not late (12 to 24 hours post-infection) in infection.
CC -!- SIMILARITY: Belongs to the PCNA family. {ECO:0000305}.
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DR EMBL; M20718; AAA21097.1; -; Genomic_DNA.
DR EMBL; L22858; AAA66679.2; -; Genomic_DNA.
DR EMBL; U04879; AAA20059.1; -; Genomic_DNA.
DR PIR; A28147; WMNVET.
DR RefSeq; NP_054078.1; NC_001623.1.
DR SMR; P11038; -.
DR PRIDE; P11038; -.
DR GeneID; 1403881; -.
DR KEGG; vg:1403881; -.
DR Proteomes; UP000008292; Genome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030337; F:DNA polymerase processivity factor activity; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR HAMAP; MF_00317; DNApol_clamp_arch; 1.
DR InterPro; IPR000730; Pr_cel_nuc_antig.
DR InterPro; IPR022649; Pr_cel_nuc_antig_C.
DR InterPro; IPR022659; Pr_cel_nuc_antig_CS.
DR InterPro; IPR022648; Pr_cel_nuc_antig_N.
DR PANTHER; PTHR11352:SF0; PTHR11352:SF0; 1.
DR Pfam; PF02747; PCNA_C; 1.
DR Pfam; PF00705; PCNA_N; 1.
DR PRINTS; PR00339; PCNACYCLIN.
DR TIGRFAMs; TIGR00590; pcna; 1.
DR PROSITE; PS01251; PCNA_1; 1.
DR PROSITE; PS00293; PCNA_2; 1.
PE 2: Evidence at transcript level;
KW DNA replication; DNA-binding; Early protein; Reference proteome.
FT CHAIN 1..256
FT /note="Probable DNA polymerase sliding clamp"
FT /id="PRO_0000149223"
FT DNA_BIND 61..80
FT /evidence="ECO:0000255"
SQ SEQUENCE 256 AA; 28635 MW; 73A8A9887AD9E532 CRC64;
MFEAEFKTGA VLKRLVETFK DLLPHATFDC DNRGVSMQVM DTSHVALVSL QLHAEGFKKY
RCDRNVPLNV SINSLSKIVK CVNERSSVLM KAEDQGDVMA FVFNNDNRIC TYTLKLMCID
VEHLGIPDSD YDCVVHMSSV EFAQVCKDMT QFDHDIIVSC SKKGLQFRAN GDIGSADVQM
SADNENFSVL KAKQTVTHTF AGDYLCHFAK AAPLAPTVTI YMSEELPFKL EYCIKDVGVL
ACFLAPKIVN NDEEIF
