ID   PCNA_SARCR              Reviewed;         260 AA.
AC   O16852;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Proliferating cell nuclear antigen;
DE            Short=PCNA;
DE   AltName: Full=Cyclin;
GN   Name=PCNA;
OS   Sarcophaga crassipalpis.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC   Sarcophagidae; Sarcophaga; Liopygia.
OX   NCBI_TaxID=59312;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9714841; DOI=10.1016/s0378-1119(98)00299-6;
RA   Tammariello S.P., Denlinger D.L.;
RT   "Cloning and sequencing of proliferating cell nuclear antigen (PCNA) from
RT   the flesh fly, Sarcophaga crassipalpis, and its expression in response to
RT   cold shock and heat shock.";
RL   Gene 215:425-429(1998).
CC   -!- FUNCTION: This protein is an auxiliary protein of DNA polymerase delta
CC       and is involved in the control of eukaryotic DNA replication by
CC       increasing the polymerase's processibility during elongation of the
CC       leading strand.
CC   -!- SUBUNIT: Homotrimer. Forms a complex with activator 1 heteropentamer in
CC       the presence of ATP (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the PCNA family. {ECO:0000305}.
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DR   EMBL; AF020427; AAC24238.1; -; Genomic_DNA.
DR   AlphaFoldDB; O16852; -.
DR   SMR; O16852; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030337; F:DNA polymerase processivity factor activity; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   HAMAP; MF_00317; DNApol_clamp_arch; 1.
DR   InterPro; IPR000730; Pr_cel_nuc_antig.
DR   InterPro; IPR022649; Pr_cel_nuc_antig_C.
DR   InterPro; IPR022659; Pr_cel_nuc_antig_CS.
DR   InterPro; IPR022648; Pr_cel_nuc_antig_N.
DR   InterPro; IPR010916; TonB_box_CS.
DR   Pfam; PF02747; PCNA_C; 1.
DR   Pfam; PF00705; PCNA_N; 1.
DR   PRINTS; PR00339; PCNACYCLIN.
DR   TIGRFAMs; TIGR00590; pcna; 1.
DR   PROSITE; PS01251; PCNA_1; 1.
DR   PROSITE; PS00293; PCNA_2; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; Nucleus.
FT   CHAIN           1..260
FT                   /note="Proliferating cell nuclear antigen"
FT                   /id="PRO_0000149171"
FT   DNA_BIND        61..80
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   260 AA;  28956 MW;  4645B748EB2996A8 CRC64;
     MFEARLINAT ILKKILDAIK ELLHEATFEC SESGIQLQAM DNSHVSLGSL TLRSDGFDKF
     RCDRNISMGM NLGSMAKILK CANNDDTVTV KAQDNADTVT FMFESPNHEK VSDYEMKLMN
     LDQEHLGIPE TDYSCVVRMP SMEFARICRD LAQFSESMLI CCTKEGVKFS ASGDVGSANV
     KLAQTSSVDK EEEAVIIEMQ EPVTLTFACR YLNAFTKATP LSAQVQLSMC ADVPLVVEYA
     IKELGHIRYY LAPKIEDDES