ID   PCNA_STYCL              Reviewed;         264 AA.
AC   P53358;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Proliferating cell nuclear antigen;
DE            Short=PCNA;
DE   AltName: Full=Cyclin;
GN   Name=PCNA;
OS   Styela clava (Sea squirt).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Stolidobranchia;
OC   Styelidae; Styela.
OX   NCBI_TaxID=7725;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8812106; DOI=10.1006/dbio.1996.0195;
RA   Swalla B.J., Jeffery W.R.;
RT   "PCNA mRNA has a 3'UTR antisense to yellow crescent RNA and is localized in
RT   ascidian eggs and embryos.";
RL   Dev. Biol. 178:23-34(1996).
CC   -!- FUNCTION: This protein is an auxiliary protein of DNA polymerase delta
CC       and is involved in the control of eukaryotic DNA replication by
CC       increasing the polymerase's processibility during elongation of the
CC       leading strand. {ECO:0000250}.
CC   -!- SUBUNIT: Homotrimer. Forms a complex with activator 1 heteropentamer in
CC       the presence of ATP (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the PCNA family. {ECO:0000305}.
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DR   EMBL; L42763; AAC37303.1; -; mRNA.
DR   AlphaFoldDB; P53358; -.
DR   SMR; P53358; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030337; F:DNA polymerase processivity factor activity; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   HAMAP; MF_00317; DNApol_clamp_arch; 1.
DR   InterPro; IPR000730; Pr_cel_nuc_antig.
DR   InterPro; IPR022649; Pr_cel_nuc_antig_C.
DR   InterPro; IPR022659; Pr_cel_nuc_antig_CS.
DR   InterPro; IPR022648; Pr_cel_nuc_antig_N.
DR   Pfam; PF02747; PCNA_C; 1.
DR   Pfam; PF00705; PCNA_N; 1.
DR   PRINTS; PR00339; PCNACYCLIN.
DR   TIGRFAMs; TIGR00590; pcna; 1.
DR   PROSITE; PS01251; PCNA_1; 1.
DR   PROSITE; PS00293; PCNA_2; 1.
PE   2: Evidence at transcript level;
KW   DNA replication; DNA-binding; Nucleus.
FT   CHAIN           1..264
FT                   /note="Proliferating cell nuclear antigen"
FT                   /id="PRO_0000149172"
FT   DNA_BIND        61..80
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   264 AA;  29260 MW;  007B96B9BB5208D0 CRC64;
     MFEARLIQGS NLKKVQEALK DIVTEASWDC TSSGISLQAM DSSHVSLVQL TLRADGFENF
     RCDRNLAMGI NMTSMAKIMK CAGNDDIITL RAEDNADMLE LIFESSKGDK YSQYEMKLMD
     LDCEQLGIPE QDYSCCVTLP SQEFGRICRD LSQIGECVVI TCTKDGVQFS AKGDLGAGKI
     KLKQNTGSDI KEEEQVTVEI SEPVQLTFAI KYLNLFAKAS PLSPSVCLSM SNNVPLVVEY
     KVADMGHIKY FLAPKIEDEE EQDS