ID   PCNA_THEFM              Reviewed;         249 AA.
AC   Q9UWR9;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=DNA polymerase sliding clamp {ECO:0000255|HAMAP-Rule:MF_00317};
DE   AltName: Full=Proliferating cell nuclear antigen homolog {ECO:0000255|HAMAP-Rule:MF_00317};
DE            Short=PCNA {ECO:0000255|HAMAP-Rule:MF_00317};
DE   AltName: Full=Tfu PCNA;
GN   Name=pcn {ECO:0000255|HAMAP-Rule:MF_00317}; Synonyms=pcnA;
OS   Thermococcus fumicolans.
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=46540;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11027519; DOI=10.1006/bbrc.2000.3481;
RA   Henneke G., Raffin J.P., Ferrari E., Jonsson Z.O., Dietrich J.,
RA   Hubscher U.;
RT   "The PCNA from Thermococcus fumicolans functionally interacts with DNA
RT   polymerase delta.";
RL   Biochem. Biophys. Res. Commun. 276:600-606(2000).
CC   -!- FUNCTION: Sliding clamp subunit that acts as a moving platform for DNA
CC       processing. Responsible for tethering the catalytic subunit of DNA
CC       polymerase and other proteins to DNA during high-speed replication.
CC       {ECO:0000255|HAMAP-Rule:MF_00317}.
CC   -!- SUBUNIT: Homotrimer. The subunits circularize to form a toroid; DNA
CC       passes through its center. Replication factor C (RFC) is required to
CC       load the toroid on the DNA. {ECO:0000255|HAMAP-Rule:MF_00317}.
CC   -!- SIMILARITY: Belongs to the PCNA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00317}.
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DR   EMBL; AJ130939; CAB59006.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9UWR9; -.
DR   SMR; Q9UWR9; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030337; F:DNA polymerase processivity factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00317; DNApol_clamp_arch; 1.
DR   InterPro; IPR000730; Pr_cel_nuc_antig.
DR   InterPro; IPR022649; Pr_cel_nuc_antig_C.
DR   InterPro; IPR022659; Pr_cel_nuc_antig_CS.
DR   InterPro; IPR022648; Pr_cel_nuc_antig_N.
DR   PANTHER; PTHR11352:SF0; PTHR11352:SF0; 1.
DR   Pfam; PF02747; PCNA_C; 1.
DR   Pfam; PF00705; PCNA_N; 1.
DR   PRINTS; PR00339; PCNACYCLIN.
DR   TIGRFAMs; TIGR00590; pcna; 1.
DR   PROSITE; PS01251; PCNA_1; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding.
FT   CHAIN           1..249
FT                   /note="DNA polymerase sliding clamp"
FT                   /id="PRO_0000149221"
SQ   SEQUENCE   249 AA;  28043 MW;  3DE42911966EFCE3 CRC64;
     MPFEIVFDGA KEFADLIATA SNLIDEAAFK VTDEGISMRA MDPSRVVLID LNLPESIFSK
     YEVEEEETIG INMDHFKKIL KRGKGKDTLI LKKGDENFLE ITFEGTAKRT FRLPLIDVEE
     LELDLPELPF TAKVVLLGEV LKEAVKDASL VSDAMKFIAK ENEFSMRAEG ETNEVEIKLT
     LEDEGLLDIE VEEETKSAYG ISYLADMVKG IGKADEVTIR FGNEMPLQMD YFIRDEGKLT
     FLLAPRVED