PCNA_THEGJ
ID PCNA_THEGJ Reviewed; 249 AA.
AC C5A5N6;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=DNA polymerase sliding clamp {ECO:0000255|HAMAP-Rule:MF_00317};
DE AltName: Full=Proliferating cell nuclear antigen homolog {ECO:0000255|HAMAP-Rule:MF_00317};
DE Short=PCNA {ECO:0000255|HAMAP-Rule:MF_00317};
GN Name=pcn {ECO:0000255|HAMAP-Rule:MF_00317}; OrderedLocusNames=TGAM_1046;
OS Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=593117;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15229 / JCM 11827 / EJ3;
RX PubMed=19558674; DOI=10.1186/gb-2009-10-6-r70;
RA Zivanovic Y., Armengaud J., Lagorce A., Leplat C., Guerin P., Dutertre M.,
RA Anthouard V., Forterre P., Wincker P., Confalonieri F.;
RT "Genome analysis and genome-wide proteomics of Thermococcus gammatolerans,
RT the most radioresistant organism known amongst the Archaea.";
RL Genome Biol. 10:R70.1-R70.23(2007).
CC -!- FUNCTION: Sliding clamp subunit that acts as a moving platform for DNA
CC processing. Responsible for tethering the catalytic subunit of DNA
CC polymerase and other proteins to DNA during high-speed replication.
CC {ECO:0000255|HAMAP-Rule:MF_00317}.
CC -!- SUBUNIT: Homotrimer. The subunits circularize to form a toroid; DNA
CC passes through its center. Replication factor C (RFC) is required to
CC load the toroid on the DNA. {ECO:0000255|HAMAP-Rule:MF_00317}.
CC -!- SIMILARITY: Belongs to the PCNA family. {ECO:0000255|HAMAP-
CC Rule:MF_00317}.
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DR EMBL; CP001398; ACS33548.1; -; Genomic_DNA.
DR RefSeq; WP_015858662.1; NC_012804.1.
DR PDB; 5A6D; X-ray; 2.80 A; A/B=1-249.
DR PDBsum; 5A6D; -.
DR AlphaFoldDB; C5A5N6; -.
DR SMR; C5A5N6; -.
DR STRING; 593117.TGAM_1046; -.
DR PaxDb; C5A5N6; -.
DR EnsemblBacteria; ACS33548; ACS33548; TGAM_1046.
DR GeneID; 7986920; -.
DR KEGG; tga:TGAM_1046; -.
DR PATRIC; fig|593117.10.peg.1043; -.
DR eggNOG; arCOG00488; Archaea.
DR HOGENOM; CLU_043978_1_0_2; -.
DR OMA; EMKLINM; -.
DR OrthoDB; 70433at2157; -.
DR Proteomes; UP000001488; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030337; F:DNA polymerase processivity factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00317; DNApol_clamp_arch; 1.
DR InterPro; IPR000730; Pr_cel_nuc_antig.
DR InterPro; IPR022649; Pr_cel_nuc_antig_C.
DR InterPro; IPR022659; Pr_cel_nuc_antig_CS.
DR InterPro; IPR022648; Pr_cel_nuc_antig_N.
DR PANTHER; PTHR11352:SF0; PTHR11352:SF0; 1.
DR Pfam; PF02747; PCNA_C; 1.
DR Pfam; PF00705; PCNA_N; 1.
DR PRINTS; PR00339; PCNACYCLIN.
DR TIGRFAMs; TIGR00590; pcna; 1.
DR PROSITE; PS01251; PCNA_1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; DNA replication; DNA-binding.
FT CHAIN 1..249
FT /note="DNA polymerase sliding clamp"
FT /id="PRO_1000205082"
FT STRAND 3..8
FT /evidence="ECO:0007829|PDB:5A6D"
FT HELIX 10..21
FT /evidence="ECO:0007829|PDB:5A6D"
FT STRAND 25..31
FT /evidence="ECO:0007829|PDB:5A6D"
FT STRAND 33..41
FT /evidence="ECO:0007829|PDB:5A6D"
FT STRAND 47..54
FT /evidence="ECO:0007829|PDB:5A6D"
FT HELIX 55..57
FT /evidence="ECO:0007829|PDB:5A6D"
FT STRAND 58..63
FT /evidence="ECO:0007829|PDB:5A6D"
FT STRAND 67..72
FT /evidence="ECO:0007829|PDB:5A6D"
FT HELIX 73..80
FT /evidence="ECO:0007829|PDB:5A6D"
FT STRAND 88..93
FT /evidence="ECO:0007829|PDB:5A6D"
FT STRAND 95..114
FT /evidence="ECO:0007829|PDB:5A6D"
FT STRAND 132..137
FT /evidence="ECO:0007829|PDB:5A6D"
FT HELIX 138..149
FT /evidence="ECO:0007829|PDB:5A6D"
FT STRAND 153..159
FT /evidence="ECO:0007829|PDB:5A6D"
FT STRAND 161..169
FT /evidence="ECO:0007829|PDB:5A6D"
FT STRAND 174..180
FT /evidence="ECO:0007829|PDB:5A6D"
FT STRAND 186..193
FT /evidence="ECO:0007829|PDB:5A6D"
FT STRAND 195..200
FT /evidence="ECO:0007829|PDB:5A6D"
FT HELIX 201..208
FT /evidence="ECO:0007829|PDB:5A6D"
FT STRAND 216..221
FT /evidence="ECO:0007829|PDB:5A6D"
FT STRAND 227..233
FT /evidence="ECO:0007829|PDB:5A6D"
FT TURN 234..236
FT /evidence="ECO:0007829|PDB:5A6D"
FT STRAND 237..243
FT /evidence="ECO:0007829|PDB:5A6D"
SQ SEQUENCE 249 AA; 28125 MW; 3320BE45B71FB1AB CRC64;
MPFEIVFDGA KEFADLIATA SNLIDEAAFK ITEEGVSMRA MDPSRVVLID LNLPESIFSK
YEVEEPETIG INMDHFKKIL KRGKSKDTLI LRKGDENFLE ITFEGTAKRT FRLPLIDVEE
LELELPELPF TAKVVLLGEV LKEAIKDASL VSDSLKFIAK EDEFTMKAEG ETNEVEIKLT
LEDEGLLDLE VEEETRSAYG ISYLADMVKG IGKADEVTLR FGTEMPLQMD YFIRDEGKLT
FLLAPRVEE
