ID   PCNA_THEON              Reviewed;         249 AA.
AC   B6YVZ1;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2009, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=DNA polymerase sliding clamp {ECO:0000255|HAMAP-Rule:MF_00317};
DE   AltName: Full=Proliferating cell nuclear antigen homolog {ECO:0000255|HAMAP-Rule:MF_00317};
DE            Short=PCNA {ECO:0000255|HAMAP-Rule:MF_00317};
GN   Name=pcn {ECO:0000255|HAMAP-Rule:MF_00317}; OrderedLocusNames=TON_0826;
OS   Thermococcus onnurineus (strain NA1).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=523850;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NA1;
RX   PubMed=18790866; DOI=10.1128/jb.00746-08;
RA   Lee H.S., Kang S.G., Bae S.S., Lim J.K., Cho Y., Kim Y.J., Jeon J.H.,
RA   Cha S.-S., Kwon K.K., Kim H.-T., Park C.-J., Lee H.-W., Kim S.I., Chun J.,
RA   Colwell R.R., Kim S.-J., Lee J.-H.;
RT   "The complete genome sequence of Thermococcus onnurineus NA1 reveals a
RT   mixed heterotrophic and carboxydotrophic metabolism.";
RL   J. Bacteriol. 190:7491-7499(2008).
CC   -!- FUNCTION: Sliding clamp subunit that acts as a moving platform for DNA
CC       processing. Responsible for tethering the catalytic subunit of DNA
CC       polymerase and other proteins to DNA during high-speed replication.
CC       {ECO:0000255|HAMAP-Rule:MF_00317}.
CC   -!- SUBUNIT: Homotrimer. The subunits circularize to form a toroid; DNA
CC       passes through its center. Replication factor C (RFC) is required to
CC       load the toroid on the DNA. {ECO:0000255|HAMAP-Rule:MF_00317}.
CC   -!- SIMILARITY: Belongs to the PCNA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00317}.
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DR   EMBL; CP000855; ACJ16314.1; -; Genomic_DNA.
DR   RefSeq; WP_012571786.1; NC_011529.1.
DR   AlphaFoldDB; B6YVZ1; -.
DR   SMR; B6YVZ1; -.
DR   STRING; 523850.TON_0826; -.
DR   EnsemblBacteria; ACJ16314; ACJ16314; TON_0826.
DR   GeneID; 7017129; -.
DR   KEGG; ton:TON_0826; -.
DR   PATRIC; fig|523850.10.peg.833; -.
DR   eggNOG; arCOG00488; Archaea.
DR   HOGENOM; CLU_043978_1_0_2; -.
DR   OMA; EMKLINM; -.
DR   OrthoDB; 70433at2157; -.
DR   Proteomes; UP000002727; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030337; F:DNA polymerase processivity factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00317; DNApol_clamp_arch; 1.
DR   InterPro; IPR000730; Pr_cel_nuc_antig.
DR   InterPro; IPR022649; Pr_cel_nuc_antig_C.
DR   InterPro; IPR022659; Pr_cel_nuc_antig_CS.
DR   InterPro; IPR022648; Pr_cel_nuc_antig_N.
DR   PANTHER; PTHR11352:SF0; PTHR11352:SF0; 1.
DR   Pfam; PF02747; PCNA_C; 1.
DR   Pfam; PF00705; PCNA_N; 1.
DR   PRINTS; PR00339; PCNACYCLIN.
DR   TIGRFAMs; TIGR00590; pcna; 1.
DR   PROSITE; PS01251; PCNA_1; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding.
FT   CHAIN           1..249
FT                   /note="DNA polymerase sliding clamp"
FT                   /id="PRO_1000115817"
SQ   SEQUENCE   249 AA;  28138 MW;  5139271E8F3E4983 CRC64;
     MPFEIVFDGA KDFADLIATA SNLIDEAAFK ITEEGISMRA MDPSRVVLID LNLPESIFSK
     YEVEEEETVG INMDHFKKIL KRGKNKDTLI LRKGDENFLE ITFEGTAKRT FRLPLIEVEE
     LELDLPELPF TAKVVVLGEV LKEAVKDASL VSDALKFIAR ENEFIMKAEG ETNEVEIKLT
     LEDEGLLDLE VEEETKSAYG ISYLADMIKG IGKADEVIIR FGNEMPLQME YPIRDEGKLI
     FLLAPRVED