ID   PCNA_TOBAC              Reviewed;         264 AA.
AC   O82797;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Proliferating cell nuclear antigen;
DE            Short=PCNA;
GN   Name=PCNA;
OS   Nicotiana tabacum (Common tobacco).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC   Nicotiana.
OX   NCBI_TaxID=4097;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Bright Yellow 2;
RA   Padidam M., Beachy R.N., Fauquet C.M.;
RT   "Tomato leaf curl geminivirus replication is cell cycle dependent.";
RL   Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Park S.-C., Park E.-H., Cho J.W.;
RT   "Nucleotide sequence of an Nicotiana tabacum cDNA clone encoding a homolog
RT   of proliferating cell nuclear antigen.";
RL   (er) Plant Gene Register PGR99-022(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Bright Yellow 2;
RA   Ito M.;
RL   Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is an auxiliary protein of DNA polymerase delta
CC       and is involved in the control of eukaryotic DNA replication by
CC       increasing the polymerase's processibility during elongation of the
CC       leading strand. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the PCNA family. {ECO:0000305}.
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DR   EMBL; AF085197; AAC34126.1; -; mRNA.
DR   EMBL; AF038875; AAC27992.1; -; mRNA.
DR   EMBL; AB025029; BAA76349.1; -; mRNA.
DR   RefSeq; NP_001312213.1; NM_001325284.1.
DR   AlphaFoldDB; O82797; -.
DR   SMR; O82797; -.
DR   STRING; 4097.O82797; -.
DR   GeneID; 107779602; -.
DR   KEGG; nta:107779602; -.
DR   OMA; EMKLINM; -.
DR   PhylomeDB; O82797; -.
DR   Proteomes; UP000084051; Unplaced.
DR   GO; GO:0043626; C:PCNA complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030337; F:DNA polymerase processivity factor activity; IBA:GO_Central.
DR   GO; GO:0006272; P:leading strand elongation; IBA:GO_Central.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   GO; GO:0019985; P:translesion synthesis; IBA:GO_Central.
DR   HAMAP; MF_00317; DNApol_clamp_arch; 1.
DR   InterPro; IPR000730; Pr_cel_nuc_antig.
DR   InterPro; IPR022649; Pr_cel_nuc_antig_C.
DR   InterPro; IPR022659; Pr_cel_nuc_antig_CS.
DR   InterPro; IPR022648; Pr_cel_nuc_antig_N.
DR   Pfam; PF02747; PCNA_C; 1.
DR   Pfam; PF00705; PCNA_N; 1.
DR   PRINTS; PR00339; PCNACYCLIN.
DR   TIGRFAMs; TIGR00590; pcna; 1.
DR   PROSITE; PS01251; PCNA_1; 1.
DR   PROSITE; PS00293; PCNA_2; 1.
PE   2: Evidence at transcript level;
KW   DNA replication; DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..264
FT                   /note="Proliferating cell nuclear antigen"
FT                   /id="PRO_0000149188"
FT   DNA_BIND        61..80
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   264 AA;  29272 MW;  D708552B805C199C CRC64;
     MLELRLVQGS LLKKVLESIK DLVNDANFDC SATGFSLQAM DSSHVALVAL LLRSEGFEHY
     RCDRNISMGM NLANMAKMLK CAGNDDIITL KADDGSDTVT FMFESPTQDK IADFEMKLMD
     IDSEHLGIPE AEYHAIVRMP SAEFSRICKD LSSIGDTVVI SVTKEGVKFS TRGDIGTANI
     VCRQNTTVDK PEEATVIEMN EPVSLTFALR YLNSFTKATP LSNTVTISLS SELPVVVEYK
     IAEMGYIRFY LAPKIEEDEE ETKP