PCNP_BOVIN
ID PCNP_BOVIN Reviewed; 178 AA.
AC Q32PF3;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=PEST proteolytic signal-containing nuclear protein;
DE Short=PCNP;
DE Short=PEST-containing nuclear protein;
GN Name=PCNP;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Uterus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in cell cycle regulation. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with UHRF2/NIRF. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- PTM: Ubiquitinated; mediated by UHRF2 and leading to its subsequent
CC proteasomal degradation. {ECO:0000250}.
CC -!- PTM: N-terminally acetylated in a HYPK-dependent manner by the NatA
CC acetyltransferase complex which is composed of NAA10 and NAA15.
CC {ECO:0000250}.
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DR EMBL; BC108137; AAI08138.1; -; mRNA.
DR RefSeq; NP_001033294.1; NM_001038205.1.
DR AlphaFoldDB; Q32PF3; -.
DR STRING; 9913.ENSBTAP00000017901; -.
DR iPTMnet; Q32PF3; -.
DR PaxDb; Q32PF3; -.
DR PeptideAtlas; Q32PF3; -.
DR PRIDE; Q32PF3; -.
DR GeneID; 615197; -.
DR KEGG; bta:615197; -.
DR CTD; 57092; -.
DR eggNOG; ENOG502QWEZ; Eukaryota.
DR HOGENOM; CLU_118645_1_0_1; -.
DR InParanoid; Q32PF3; -.
DR OrthoDB; 1616182at2759; -.
DR TreeFam; TF333058; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR InterPro; IPR029169; PCNP.
DR PANTHER; PTHR16523; PTHR16523; 1.
DR Pfam; PF15473; PCNP; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Cell cycle; Nucleus; Phosphoprotein; Reference proteome;
KW Ubl conjugation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q8WW12"
FT CHAIN 2..178
FT /note="PEST proteolytic signal-containing nuclear protein"
FT /id="PRO_0000247957"
FT REGION 1..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 134..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..178
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q8WW12"
FT MOD_RES 53
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WW12"
FT MOD_RES 64
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q8WW12"
FT MOD_RES 77
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WW12"
FT MOD_RES 87
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WW12"
FT MOD_RES 119
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WW12"
FT MOD_RES 139
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8WW12"
FT MOD_RES 147
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WW12"
FT MOD_RES 150
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q8WW12"
FT MOD_RES 152
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q8WW12"
SQ SEQUENCE 178 AA; 18988 MW; 9CE729CC3214233F CRC64;
MADGKAGEEK PEKPQRAGAA GGPEEEAEKP VKTKTVSSSN GGENSSRSAE KRSAEDETAD
LPTKPTKISK FGFAIGSQTT KKASAISIKL GSSKPKEPVP TLAPKTLSVA AAFNEDEDSE
PEEMPPEAKM RMKNIGRDTP TSAGPNSFNK GKHGFSDNQK LWERNIKSHL GNVHDQDN
