PCNP_PONAB
ID PCNP_PONAB Reviewed; 178 AA.
AC Q5RCI9; Q5R8U4;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=PEST proteolytic signal-containing nuclear protein;
DE Short=PCNP;
DE Short=PEST-containing nuclear protein;
GN Name=PCNP;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain cortex;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in cell cycle regulation. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with UHRF2/NIRF. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5RCI9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5RCI9-2; Sequence=VSP_013882;
CC -!- PTM: Ubiquitinated; mediated by UHRF2 and leading to its subsequent
CC proteasomal degradation. {ECO:0000250}.
CC -!- PTM: N-terminally acetylated in a HYPK-dependent manner by the NatA
CC acetyltransferase complex which is composed of NAA10 and NAA15.
CC {ECO:0000250}.
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DR EMBL; CR858281; CAH90518.1; -; mRNA.
DR EMBL; CR859655; CAH91816.1; -; mRNA.
DR EMBL; CR861316; CAH93381.1; -; mRNA.
DR RefSeq; NP_001125274.1; NM_001131802.1. [Q5RCI9-1]
DR RefSeq; NP_001128906.1; NM_001135434.1. [Q5RCI9-2]
DR AlphaFoldDB; Q5RCI9; -.
DR STRING; 9601.ENSPPYP00000015195; -.
DR Ensembl; ENSPPYT00000015801; ENSPPYP00000015195; ENSPPYG00000013591. [Q5RCI9-1]
DR Ensembl; ENSPPYT00000057725; ENSPPYP00000039126; ENSPPYG00000013591. [Q5RCI9-2]
DR GeneID; 100172171; -.
DR GeneID; 100189850; -.
DR KEGG; pon:100172171; -.
DR CTD; 57092; -.
DR eggNOG; ENOG502QWEZ; Eukaryota.
DR GeneTree; ENSGT00390000010218; -.
DR HOGENOM; CLU_118645_1_0_1; -.
DR InParanoid; Q5RCI9; -.
DR Proteomes; UP000001595; Chromosome 3.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:Ensembl.
DR InterPro; IPR029169; PCNP.
DR PANTHER; PTHR16523; PTHR16523; 1.
DR Pfam; PF15473; PCNP; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Alternative splicing; Cell cycle; Nucleus; Phosphoprotein;
KW Reference proteome; Ubl conjugation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q8WW12"
FT CHAIN 2..178
FT /note="PEST proteolytic signal-containing nuclear protein"
FT /id="PRO_0000058255"
FT REGION 1..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 134..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..178
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q8WW12"
FT MOD_RES 53
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WW12"
FT MOD_RES 64
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q8WW12"
FT MOD_RES 77
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WW12"
FT MOD_RES 87
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WW12"
FT MOD_RES 119
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WW12"
FT MOD_RES 139
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8WW12"
FT MOD_RES 147
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WW12"
FT MOD_RES 150
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q8WW12"
FT MOD_RES 152
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q8WW12"
FT VAR_SEQ 1..123
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_013882"
SQ SEQUENCE 178 AA; 18967 MW; 864C92488DB61FFA CRC64;
MADGKAGEEK PEKSQRAGAA GGPEEEAEKP VKTKTVSSSN GGESSSRSAE KRSAEEEAVD
LPTKPTKISK FGFAIGSQTT KKASAISIKL GSSKPKETVP TLAPKTLSVA AAFNEDEDSE
PEEMPPEAKM RMKNIGRDTP TSAGPNSFNK GKHGFSDNQK LWERNIKSHL GNVHDQDN
