ID   PCNP_RAT                Reviewed;         189 AA.
AC   Q7TP40;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=PEST proteolytic signal-containing nuclear protein;
DE            Short=PCNP;
DE            Short=PEST-containing nuclear protein;
DE   AltName: Full=Liver regeneration-related protein LRRG084;
GN   Name=Pcnp; ORFNames=Ab2-416;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RA   Xu C.S., Li W.Q., Li Y.C., Yang K.J., Yan H.M., Chang C.F., Zhao L.F.,
RA   Ma H., Wang L., Wang S.F., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y.,
RA   Shi J.B., Rahman S., Wang Q.N., Zhang J.B.;
RT   "Liver regeneration after PH.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130; THR-150 AND SER-158, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: May be involved in cell cycle regulation. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with UHRF2/NIRF. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- PTM: Ubiquitinated; mediated by UHRF2 and leading to its subsequent
CC       proteasomal degradation. {ECO:0000250}.
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DR   EMBL; AY325209; AAP92610.1; -; mRNA.
DR   RefSeq; NP_001041311.1; NM_001047846.1.
DR   AlphaFoldDB; Q7TP40; -.
DR   STRING; 10116.ENSRNOP00000039022; -.
DR   iPTMnet; Q7TP40; -.
DR   PhosphoSitePlus; Q7TP40; -.
DR   jPOST; Q7TP40; -.
DR   PaxDb; Q7TP40; -.
DR   PRIDE; Q7TP40; -.
DR   Ensembl; ENSRNOT00000039997; ENSRNOP00000039022; ENSRNOG00000028411.
DR   GeneID; 288165; -.
DR   KEGG; rno:288165; -.
DR   UCSC; RGD:1563775; rat.
DR   CTD; 57092; -.
DR   RGD; 1563775; Pcnp.
DR   eggNOG; ENOG502QWEZ; Eukaryota.
DR   GeneTree; ENSGT00390000010218; -.
DR   HOGENOM; CLU_118645_1_0_1; -.
DR   InParanoid; Q7TP40; -.
DR   OrthoDB; 1616182at2759; -.
DR   PhylomeDB; Q7TP40; -.
DR   TreeFam; TF333058; -.
DR   PRO; PR:Q7TP40; -.
DR   Proteomes; UP000002494; Chromosome 11.
DR   Genevisible; Q7TP40; RN.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISS:HGNC-UCL.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; ISS:HGNC-UCL.
DR   GO; GO:0016567; P:protein ubiquitination; ISS:HGNC-UCL.
DR   InterPro; IPR029169; PCNP.
DR   PANTHER; PTHR16523; PTHR16523; 1.
DR   Pfam; PF15473; PCNP; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Cell cycle; Nucleus; Phosphoprotein; Reference proteome;
KW   Ubl conjugation.
FT   CHAIN           1..189
FT                   /note="PEST proteolytic signal-containing nuclear protein"
FT                   /id="PRO_0000058256"
FT   REGION          21..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          145..169
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        44..58
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        59..74
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        150..165
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         64
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8WW12"
FT   MOD_RES         75
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8WW12"
FT   MOD_RES         88
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8WW12"
FT   MOD_RES         98
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8WW12"
FT   MOD_RES         130
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         150
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         158
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         161
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8WW12"
FT   MOD_RES         163
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8WW12"
SQ   SEQUENCE   189 AA;  20195 MW;  92951F2F7FDC48C2 CRC64;
     MGASCTATQS QFLLYTLTSS EETVGSVGDS CRGPEEEAEK PVKTKTVSSS NGGESSSRSA
     EKRSAEDEAA DLPTKPTKMS KFGFAIGSQT ARKASAISIR LGASKPKETV PTLAPKTLSV
     AAAFNEDEDS EPEEMPPEAK MRMKNIGRDT PTSAGPNSFN KGKHGFSDNQ KLWERNIKSH
     LGNVHDQDN