ID   PCOB_ECOLX              Reviewed;         296 AA.
AC   Q47453;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Copper resistance protein B;
DE   Flags: Precursor;
GN   Name=pcoB;
OS   Escherichia coli.
OG   Plasmid pRJ1004.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8594334; DOI=10.1111/j.1365-2958.1995.mmi_17061153.x;
RA   Brown N.L., Barrett S.R., Camakaris J., Lee B.T.O., Rouch D.A.;
RT   "Molecular genetics and transport analysis of the copper-resistance
RT   determinant (pco) from Escherichia coli plasmid pRJ1004.";
RL   Mol. Microbiol. 17:1153-1166(1995).
CC   -!- FUNCTION: Required for the copper-inducible expression of copper
CC       resistance.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Peripheral
CC       membrane protein {ECO:0000305}.
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DR   EMBL; X83541; CAA58526.1; -; Genomic_DNA.
DR   PIR; S70160; S52254.
DR   RefSeq; WP_001378118.1; NZ_WNUB01000039.1.
DR   AlphaFoldDB; Q47453; -.
DR   STRING; 481805.EcolC_3415; -.
DR   TCDB; 1.B.76.1.5; the copper resistance putative porin (copb) family.
DR   GeneID; 61329828; -.
DR   GeneID; 64297917; -.
DR   GeneID; 67514214; -.
DR   eggNOG; COG3667; Bacteria.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0006878; P:cellular copper ion homeostasis; IEA:InterPro.
DR   InterPro; IPR007939; Cu-R_B_prcur.
DR   Pfam; PF05275; CopB; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Copper; Membrane; Plasmid; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..296
FT                   /note="Copper resistance protein B"
FT                   /id="PRO_0000022019"
SQ   SEQUENCE   296 AA;  32945 MW;  727A5A55CB556ECC CRC64;
     MKRNLKAIPV LVAGLFTSQL SIAAGSVSAD PHAGHDMSAM QMPADENFTE MTSMEPIVTE
     SRTPIPPVTD ADRKAAFGNL QGHAIHDSAI NYLVLLDQLE WQRSDNTNNF SWSVNSWIGG
     DTDRIWLKSE GERSNGETEA AEAQLLWGHA VGPWWDLVAG VRQDFRPASA RTWAAVGFQG
     LALYNFESEI TGFVSNGGKA ALRLGGEYDV LLTNRLILQP SYEVNFYSQD DESRGRGRGL
     TDTELGLRLR YEIRREFAPY IGVSWNQLYG KTSDMAKREG EKDHQVVFLA GARIWF