ID   PCOD_ECOLX              Reviewed;         309 AA.
AC   Q47455;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Copper resistance protein D;
GN   Name=pcoD;
OS   Escherichia coli.
OG   Plasmid pRJ1004.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8594334; DOI=10.1111/j.1365-2958.1995.mmi_17061153.x;
RA   Brown N.L., Barrett S.R., Camakaris J., Lee B.T.O., Rouch D.A.;
RT   "Molecular genetics and transport analysis of the copper-resistance
RT   determinant (pco) from Escherichia coli plasmid pRJ1004.";
RL   Mol. Microbiol. 17:1153-1166(1995).
CC   -!- FUNCTION: Required for the copper-inducible expression of copper
CC       resistance.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CopD family. {ECO:0000305}.
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DR   EMBL; X83541; CAA58528.1; -; Genomic_DNA.
DR   PIR; S70163; S52256.
DR   RefSeq; WP_000998778.1; NZ_WVVT01000006.1.
DR   AlphaFoldDB; Q47455; -.
DR   STRING; 481805.EcolC_3413; -.
DR   TCDB; 9.B.62.1.1; the copper resistance (copd) family.
DR   GeneID; 60374708; -.
DR   GeneID; 61383278; -.
DR   GeneID; 67464112; -.
DR   eggNOG; COG1276; Bacteria.
DR   OMA; WCIRILA; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006825; P:copper ion transport; IEA:InterPro.
DR   InterPro; IPR032694; CopC/D.
DR   InterPro; IPR008457; Cu-R_CopD.
DR   PANTHER; PTHR34820; PTHR34820; 1.
DR   Pfam; PF05425; CopD; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Copper; Membrane; Plasmid;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..309
FT                   /note="Copper resistance protein D"
FT                   /id="PRO_0000218126"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..254
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   309 AA;  33848 MW;  4234CBC77FB0FA55 CRC64;
     MNDLIMIVIR FLLYLDLMVI FGLPFFQIYG ISGVRHETYN LTNFRSFITF AVVTGIILTG
     INMLLVSNAM SGVTDLRELS IHVIEMVIEE TDVGISWIVR LCALFTTLGA LFLYTNKRVL
     SCLLMTMSGG VALATLAWGG HAVMHDGLHY YLHLLSDLTH LGAAGAWTGA LVAFAILLMR
     RNEHNAQSVI VISDSLAKFA TAGTVIVVAL ILSALVNYLY IAEGNLTPLF NSSWGRILLA
     KTALFVLMLL LAAANRFHLG PRLEVMVREG NYDRSVALMR NSILTEFVVA IIILGAVAWL
     GMLAPSQVS