ID   PCOE_ECOLX              Reviewed;         144 AA.
AC   Q47459;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Probable copper-binding protein PcoE;
DE   Flags: Precursor;
GN   Name=pcoE;
OS   Escherichia coli.
OG   Plasmid pRJ1004.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8594334; DOI=10.1111/j.1365-2958.1995.mmi_17061153.x;
RA   Brown N.L., Barrett S.R., Camakaris J., Lee B.T.O., Rouch D.A.;
RT   "Molecular genetics and transport analysis of the copper-resistance
RT   determinant (pco) from Escherichia coli plasmid pRJ1004.";
RL   Mol. Microbiol. 17:1153-1166(1995).
RN   [2]
RP   PROTEIN SEQUENCE OF 21-24.
RX   PubMed=9930866; DOI=10.1038/5545;
RA   Gupta A., Matsui K., Lo J.-F., Silver S.;
RT   "Molecular basis for resistance to silver cations in Salmonella.";
RL   Nat. Med. 5:183-188(1999).
CC   -!- FUNCTION: Required for the copper-inducible expression of copper
CC       resistance. Activated by the two-component regulatory system CusS/CusR.
CC   -!- SUBCELLULAR LOCATION: Periplasm.
CC   -!- INDUCTION: By copper.
CC   -!- SIMILARITY: To S.typhimurium SilE. {ECO:0000305}.
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DR   EMBL; X83541; CAA58532.1; -; Genomic_DNA.
DR   PIR; S70162; S52259.
DR   RefSeq; WP_058799199.1; NZ_VTVT01000044.1.
DR   AlphaFoldDB; Q47459; -.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Copper; Direct protein sequencing; Metal-binding; Periplasm; Plasmid;
KW   Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000269|PubMed:9930866"
FT   CHAIN           21..144
FT                   /note="Probable copper-binding protein PcoE"
FT                   /id="PRO_0000022022"
FT   REGION          86..144
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..144
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   144 AA;  15746 MW;  DA4CACA72F3CCCE8 CRC64;
     MKKILVSFVA IMAVASSAMA AETMNMHDQV NNAQAPAHQM QSSAEKSAVQ GDSMTMMDMS
     SHDQAAMSHD MMQNGNSAAH QDMAEMHKKM MKSKPAASNE TAKSFSEMNE HEKSAVVHEK
     ANNGQSSVIH QQQAEKHRSQ ITQN