PCOR_ECOLX
ID PCOR_ECOLX Reviewed; 226 AA.
AC Q47456;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 125.
DE RecName: Full=Transcriptional regulatory protein PcoR;
GN Name=pcoR;
OS Escherichia coli.
OG Plasmid pRJ1004.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=562;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=RJ97;
RX PubMed=8594334; DOI=10.1111/j.1365-2958.1995.mmi_17061153.x;
RA Brown N.L., Barrett S.R., Camakaris J., Lee B.T.O., Rouch D.A.;
RT "Molecular genetics and transport analysis of the copper-resistance
RT determinant (pco) from Escherichia coli plasmid pRJ1004.";
RL Mol. Microbiol. 17:1153-1166(1995).
RN [2]
RP TRANSCRIPTIONAL REGULATION.
RX PubMed=9141682; DOI=10.1099/00221287-143-4-1191;
RA Rouch D.A., Brown N.L.;
RT "Copper-inducible transcriptional regulation at two promoters in the
RT Escherichia coli copper resistance determinant pco.";
RL Microbiology 143:1191-1202(1997).
CC -!- FUNCTION: Probable member of a two-component regulatory system
CC PcoS/PcoR. May be involved in the activation of copper resistance gene
CC operon pcoABCD by binding to a specific site on the cop operon promoter
CC (copper box).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- PTM: Phosphorylated by PcoS. {ECO:0000305}.
CC -!- MISCELLANEOUS: Transcriptional regulation studies were performed in
CC E.coli K12.
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DR EMBL; X83541; CAA58529.1; -; Genomic_DNA.
DR PIR; S70164; S70164.
DR RefSeq; WP_001188930.1; NZ_WVVT01000006.1.
DR AlphaFoldDB; Q47456; -.
DR BMRB; Q47456; -.
DR SMR; Q47456; -.
DR STRING; 481805.EcolC_3412; -.
DR GeneID; 60374751; -.
DR GeneID; 61383279; -.
DR GeneID; 64297920; -.
DR GeneID; 67514217; -.
DR eggNOG; COG0745; Bacteria.
DR OMA; VCMSKLR; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00383; trans_reg_C; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR006291; PcoR.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR039420; WalR-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR48111; PTHR48111; 1.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00448; REC; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR TIGRFAMs; TIGR01387; cztR_silR_copR; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW Activator; Copper; Cytoplasm; DNA-binding; Phosphoprotein; Plasmid;
KW Transcription; Transcription regulation; Two-component regulatory system.
FT CHAIN 1..226
FT /note="Transcriptional regulatory protein PcoR"
FT /id="PRO_0000081077"
FT DOMAIN 3..117
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DNA_BIND 125..223
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT MOD_RES 52
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 226 AA; 25676 MW; 80502DAE2B23B23D CRC64;
MQRILIVEDE QKTGRYLQQG LVEEGYQADL FNNGRDGLGA ASKGQYDLII LDVMLPFLDG
WQIISALRES GHEEPVLFLT AKDNVRDKVK GLELGADDYL IKPFDFTELV ARVRTLLRRA
RSQAATVCTI ADMTVDMVRR TVIRSGKKIH LTGKEYVLLE LLLQRTGEVL PRSLISSLVW
NMNFDSDTNV IDVAVRRLRS KIDDDFEPKL IHTVRGAGYV LEIREE
