ID   PCOTH_HUMAN             Reviewed;         107 AA.
AC   Q58A44;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 2.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Prostate collagen triple helix protein;
DE   AltName: Full=C1QTNF9B antisense RNA 1;
DE   AltName: Full=C1QTNF9B antisense gene protein 1;
GN   Name=PCOTH; Synonyms=C1QTNF9B-AS1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostatic carcinoma;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 7-107, POSSIBLE FUNCTION, SUBCELLULAR
RP   LOCATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Prostatic carcinoma;
RX   PubMed=15930275; DOI=10.1158/0008-5472.can-04-4564;
RA   Anazawa Y., Nakagawa H., Furihara M., Ashida S., Tamura K., Yoshioka H.,
RA   Shuin T., Fujioka T., Katagiri T., Nakamura Y.;
RT   "PCOTH, a novel gene overexpressed in prostate cancers, promotes prostate
RT   cancer cell growth through phosphorylation of oncoprotein TAF-Ibeta/SET.";
RL   Cancer Res. 65:4578-4586(2005).
CC   -!- FUNCTION: May be involved in growth and survival of prostate cancer
CC       cells through the TAF-Ibeta pathway.
CC   -!- INTERACTION:
CC       Q58A44; P25788: PSMA3; NbExp=3; IntAct=EBI-10243387, EBI-348380;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15930275}.
CC   -!- TISSUE SPECIFICITY: Expressed in prostate and testis. Weakly or not
CC       expressed in other tissues. Overexpressed in prostate cancers.
CC       {ECO:0000269|PubMed:15930275}.
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DR   EMBL; BC015452; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AB113650; BAD93185.1; -; mRNA.
DR   RefSeq; NP_001014442.2; NM_001014442.3.
DR   RefSeq; NP_001335042.1; NM_001348113.1.
DR   RefSeq; NP_001335043.1; NM_001348114.1.
DR   AlphaFoldDB; Q58A44; -.
DR   BioGRID; 139079; 1.
DR   IntAct; Q58A44; 1.
DR   BioMuta; PCOTH; -.
DR   jPOST; Q58A44; -.
DR   PaxDb; Q58A44; -.
DR   PRIDE; Q58A44; -.
DR   DNASU; 542767; -.
DR   GeneID; 542767; -.
DR   CTD; 542767; -.
DR   DisGeNET; 542767; -.
DR   GeneCards; PCOTH; -.
DR   HGNC; HGNC:39839; PCOTH.
DR   neXtProt; NX_Q58A44; -.
DR   InParanoid; Q58A44; -.
DR   PhylomeDB; Q58A44; -.
DR   PathwayCommons; Q58A44; -.
DR   SignaLink; Q58A44; -.
DR   BioGRID-ORCS; 542767; 9 hits in 159 CRISPR screens.
DR   ChiTaRS; C1QTNF9B-AS1; human.
DR   GenomeRNAi; 542767; -.
DR   Pharos; Q58A44; Tdark.
DR   PRO; PR:Q58A44; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q58A44; protein.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..107
FT                   /note="Prostate collagen triple helix protein"
FT                   /id="PRO_0000337141"
FT   REGION          47..107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   107 AA;  10968 MW;  B738A5D9E95AF097 CRC64;
     MWILSNLMGT SEEGNLLSTV SPTVKALFGK TRVSPIFPFS PRSPFQPLIP RTPGSPWGPV
     GPASPLGPGF PIGPMGPGKP VGPKGPMLPL GPSGPVGPTS PLFPFCP