PCP11_ARATH
ID PCP11_ARATH Reviewed; 104 AA.
AC P0DN98; A0A1P8AYZ5;
DT 10-MAY-2017, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2017, sequence version 1.
DT 03-AUG-2022, entry version 25.
DE RecName: Full=Precursor of CEP11 {ECO:0000303|PubMed:24179096};
DE Short=PCEP11 {ECO:0000303|PubMed:24179096};
DE Contains:
DE RecName: Full=C-terminally encoded peptide 11 {ECO:0000303|PubMed:24179096};
DE Short=CEP11 {ECO:0000303|PubMed:24179096};
DE Flags: Precursor;
GN Name=CEP11 {ECO:0000303|PubMed:24179096};
GN OrderedLocusNames=At2g23445 {ECO:0000312|Araport:AT2G23445};
GN ORFNames=F26B6 {ECO:0000305};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY.
RC STRAIN=cv. Columbia;
RX PubMed=24179095; DOI=10.1093/jxb/ert331;
RA Roberts I., Smith S., De Rybel B., Van Den Broeke J., Smet W.,
RA De Cokere S., Mispelaere M., De Smet I., Beeckman T.;
RT "The CEP family in land plants: evolutionary analyses, expression studies,
RT and role in Arabidopsis shoot development.";
RL J. Exp. Bot. 64:5371-5381(2013).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=24179096; DOI=10.1093/jxb/ert332;
RA Delay C., Imin N., Djordjevic M.A.;
RT "CEP genes regulate root and shoot development in response to environmental
RT cues and are specific to seed plants.";
RL J. Exp. Bot. 64:5383-5394(2013).
RN [6]
RP FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=cv. No-0;
RX PubMed=25324386; DOI=10.1126/science.1257800;
RA Tabata R., Sumida K., Yoshii T., Ohyama K., Shinohara H., Matsubayashi Y.;
RT "Perception of root-derived peptides by shoot LRR-RKs mediates systemic N-
RT demand signaling.";
RL Science 346:343-346(2014).
CC -!- FUNCTION: Extracellular signaling peptide that may regulate primary
CC root growth rate and systemic nitrogen (N)-demand signaling (By
CC similarity). Mediates up-regulation of genes involved in N uptake and
CC assimilation pathways (PubMed:25324386). {ECO:0000250|UniProtKB:Q8L8Y3,
CC ECO:0000269|PubMed:25324386}.
CC -!- SUBUNIT: Interacts with CEP receptors (e.g. CEPR1 and CEPR2).
CC {ECO:0000250|UniProtKB:Q8L8Y3}.
CC -!- SUBCELLULAR LOCATION: [C-terminally encoded peptide 11]: Secreted,
CC extracellular space, apoplast {ECO:0000250|UniProtKB:O80460}.
CC Note=Accumulates in xylem sap. {ECO:0000250|UniProtKB:O80460}.
CC -!- TISSUE SPECIFICITY: Expressed in lateral root primordia and in lateral
CC roots excluding the meristem region. {ECO:0000269|PubMed:25324386}.
CC -!- PTM: The mature small signaling peptide is generated by proteolytic
CC processing of the longer precursor. {ECO:0000250|UniProtKB:Q8L8Y3}.
CC -!- SIMILARITY: Belongs to the C-terminally encoded plant signaling peptide
CC (CEP) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ANM61833.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC003040; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002685; ANM61833.1; ALT_SEQ; Genomic_DNA.
DR EMBL; DR354022; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; DR380230; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_001324028.1; NM_001335852.1.
DR AlphaFoldDB; P0DN98; -.
DR PRIDE; P0DN98; -.
DR EnsemblPlants; AT2G23445.1; AT2G23445.1; AT2G23445.
DR GeneID; 28718295; -.
DR Gramene; AT2G23445.1; AT2G23445.1; AT2G23445.
DR KEGG; ath:AT2G23445; -.
DR Araport; AT2G23445; -.
DR OrthoDB; 1595455at2759; -.
DR PRO; PR:P0DN98; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; P0DN98; baseline and differential.
DR GO; GO:0048046; C:apoplast; ISS:UniProtKB.
DR GO; GO:0005179; F:hormone activity; ISS:UniProtKB.
DR GO; GO:1902025; P:nitrate import; IDA:UniProtKB.
DR GO; GO:2000280; P:regulation of root development; ISS:UniProtKB.
PE 2: Evidence at transcript level;
KW Apoplast; Developmental protein; Hormone; Hydroxylation;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT PROPEP 28..85
FT /evidence="ECO:0000305"
FT /id="PRO_0000440004"
FT PEPTIDE 86..100
FT /note="C-terminally encoded peptide 11"
FT /evidence="ECO:0000250|UniProtKB:Q058G9"
FT /id="PRO_0000440005"
FT PROPEP 101..104
FT /evidence="ECO:0000305"
FT /id="PRO_0000440006"
FT REGION 37..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..59
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..75
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 92
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:Q058G9"
FT MOD_RES 96
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:Q8L8Y3"
FT CONFLICT 45
FT /note="S -> SHHH (in Ref. 3; DR354022/DR380230)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 104 AA; 12212 MW; 9E3DF767DDF1412B CRC64;
MAKTRRVIYL FLTIVLLFCE LIDEAQGSRF RCHHSEDYSC KKRSSHHHHH HHHHQQQQHH
HKDTPPEELQ GSIKTRRSKD IYGLNAFRST EPGHSPGVGH LIKT
