PCP12_ARATH
ID PCP12_ARATH Reviewed; 92 AA.
AC P0DN99; Q9C6V7;
DT 10-MAY-2017, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2017, sequence version 1.
DT 03-AUG-2022, entry version 30.
DE RecName: Full=Precursor of CEP12 {ECO:0000303|PubMed:24179096};
DE Short=PCEP12 {ECO:0000303|PubMed:24179096};
DE Contains:
DE RecName: Full=C-terminally encoded peptide 12 {ECO:0000303|PubMed:24179096};
DE Short=CEP12 {ECO:0000303|PubMed:24179096};
DE Flags: Precursor;
GN Name=CEP12 {ECO:0000303|PubMed:24179096};
GN OrderedLocusNames=At1g31670 {ECO:0000312|Araport:AT1G31670};
GN ORFNames=F27M3.13 {ECO:0000312|EMBL:AAG60154.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP INDUCTION BY JASMONIC ACID, AND GENE FAMILY.
RC STRAIN=cv. Columbia;
RX PubMed=24179095; DOI=10.1093/jxb/ert331;
RA Roberts I., Smith S., De Rybel B., Van Den Broeke J., Smet W.,
RA De Cokere S., Mispelaere M., De Smet I., Beeckman T.;
RT "The CEP family in land plants: evolutionary analyses, expression studies,
RT and role in Arabidopsis shoot development.";
RL J. Exp. Bot. 64:5371-5381(2013).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=24179096; DOI=10.1093/jxb/ert332;
RA Delay C., Imin N., Djordjevic M.A.;
RT "CEP genes regulate root and shoot development in response to environmental
RT cues and are specific to seed plants.";
RL J. Exp. Bot. 64:5383-5394(2013).
CC -!- FUNCTION: Extracellular signaling peptide that may regulate primary
CC root growth rate and systemic nitrogen (N)-demand signaling.
CC {ECO:0000250|UniProtKB:Q8L8Y3}.
CC -!- SUBUNIT: Interacts with CEP receptors (e.g. CEPR1 and CEPR2).
CC {ECO:0000250|UniProtKB:Q8L8Y3}.
CC -!- SUBCELLULAR LOCATION: [C-terminally encoded peptide 12]: Secreted,
CC extracellular space, apoplast {ECO:0000250|UniProtKB:O80460}.
CC Note=Accumulates in xylem sap. {ECO:0000250|UniProtKB:O80460}.
CC -!- INDUCTION: Induced by jasmonic acid (JA).
CC {ECO:0000269|PubMed:24179095}.
CC -!- PTM: The mature small signaling peptide is generated by proteolytic
CC processing of the longer precursor. {ECO:0000250|UniProtKB:Q8L8Y3}.
CC -!- SIMILARITY: Belongs to the C-terminally encoded plant signaling peptide
CC (CEP) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG60154.1; Type=Erroneous gene model prediction; Note=The predicted gene At1g31670 has been split into 2 genes: At1g31670 and At1g31672.; Evidence={ECO:0000305};
CC Sequence=AEE31382.1; Type=Erroneous gene model prediction; Note=The predicted gene At1g31670 has been split into 2 genes: At1g31670 and At1g31672.; Evidence={ECO:0000305};
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DR EMBL; AC074360; AAG60154.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE31382.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; NP_174448.1; NM_102902.2.
DR AlphaFoldDB; P0DN99; -.
DR SMR; P0DN99; -.
DR PRIDE; P0DN99; -.
DR EnsemblPlants; AT1G31670.1; AT1G31670.1; AT1G31670.
DR GeneID; 840054; -.
DR Gramene; AT1G31670.1; AT1G31670.1; AT1G31670.
DR KEGG; ath:AT1G31670; -.
DR Araport; AT1G31670; -.
DR OrthoDB; 1320015at2759; -.
DR PRO; PR:P0DN99; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; P0DN99; baseline and differential.
DR GO; GO:0048046; C:apoplast; ISS:UniProtKB.
DR GO; GO:0005179; F:hormone activity; ISS:UniProtKB.
DR GO; GO:1902025; P:nitrate import; ISS:UniProtKB.
DR GO; GO:2000280; P:regulation of root development; ISS:UniProtKB.
DR GO; GO:0009753; P:response to jasmonic acid; IEP:UniProtKB.
DR GO; GO:0048364; P:root development; IEA:InterPro.
DR InterPro; IPR033250; CEP.
DR PANTHER; PTHR33348; PTHR33348; 1.
PE 2: Evidence at transcript level;
KW Apoplast; Developmental protein; Hormone; Hydroxylation;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT PROPEP 31..70
FT /evidence="ECO:0000305"
FT /id="PRO_0000440007"
FT PEPTIDE 71..85
FT /note="C-terminally encoded peptide 12"
FT /evidence="ECO:0000250|UniProtKB:Q058G9"
FT /id="PRO_0000440008"
FT PROPEP 86..92
FT /evidence="ECO:0000305"
FT /id="PRO_0000440009"
FT REGION 70..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 74
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:Q8L8Y3"
FT MOD_RES 79
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:Q058G9"
SQ SEQUENCE 92 AA; 10321 MW; 77365F22968F36D3 CRC64;
MVNRDNSIVA LSFFMLFLLV LHLHFETTTA ARKPVRVFGP PSSIEWSPPS PPKDDFEWFE
INIYKNIEQT AFRPTGQGPS QGIGHKDPPG AP
