PCP13_ARATH
ID PCP13_ARATH Reviewed; 93 AA.
AC Q9FZ54;
DT 10-MAY-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Precursor of CEP13 {ECO:0000303|PubMed:24179096};
DE Short=PCEP13 {ECO:0000303|PubMed:24179096};
DE Contains:
DE RecName: Full=C-terminally encoded peptide 13 {ECO:0000303|PubMed:24179096};
DE Short=CEP13 {ECO:0000303|PubMed:24179096};
DE Flags: Precursor;
GN Name=CEP13 {ECO:0000303|PubMed:24179096};
GN OrderedLocusNames=At1g16950 {ECO:0000312|Araport:AT1G16950};
GN ORFNames=F17F16.23 {ECO:0000312|EMBL:AEE29525.1},
GN F5I1.4 {ECO:0000312|EMBL:AAF99837.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis cDNA clones.";
RL Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP INDUCTION BY GIBBERELLIC ACID AND NITROGEN, AND GENE FAMILY.
RC STRAIN=cv. Columbia;
RX PubMed=24179095; DOI=10.1093/jxb/ert331;
RA Roberts I., Smith S., De Rybel B., Van Den Broeke J., Smet W.,
RA De Cokere S., Mispelaere M., De Smet I., Beeckman T.;
RT "The CEP family in land plants: evolutionary analyses, expression studies,
RT and role in Arabidopsis shoot development.";
RL J. Exp. Bot. 64:5371-5381(2013).
RN [5]
RP INDUCTION BY OSMOTIC STRESS; AMMONIUM CHLORIDE STARVATION; NITROGEN
RP DEPLETION AND NITRATE DEPLETION, GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=24179096; DOI=10.1093/jxb/ert332;
RA Delay C., Imin N., Djordjevic M.A.;
RT "CEP genes regulate root and shoot development in response to environmental
RT cues and are specific to seed plants.";
RL J. Exp. Bot. 64:5383-5394(2013).
CC -!- FUNCTION: Extracellular signaling peptide that may regulate primary
CC root growth rate and systemic nitrogen (N)-demand signaling.
CC {ECO:0000250|UniProtKB:Q8L8Y3}.
CC -!- SUBUNIT: Interacts with CEP receptors (e.g. CEPR1 and CEPR2).
CC {ECO:0000250|UniProtKB:Q8L8Y3}.
CC -!- SUBCELLULAR LOCATION: [C-terminally encoded peptide 13]: Secreted,
CC extracellular space, apoplast {ECO:0000250|UniProtKB:O80460}.
CC Note=Accumulates in xylem sap. {ECO:0000250|UniProtKB:O80460}.
CC -!- INDUCTION: Induced by gibberellic acid (GA) but repressed by nitrogen
CC (N) (PubMed:24179095). Accumulates in roots in response to nitrate and
CC ammonium chloride NH(4)Cl depletion and to osmotic stress (e.g.
CC mannitol). Repressed in shoots by nitrogen starvation
CC (PubMed:24179096). {ECO:0000269|PubMed:24179095,
CC ECO:0000269|PubMed:24179096}.
CC -!- PTM: The mature small signaling peptide is generated by proteolytic
CC processing of the longer precursor. {ECO:0000250|UniProtKB:Q8L8Y3}.
CC -!- SIMILARITY: Belongs to the C-terminally encoded plant signaling peptide
CC (CEP) family. {ECO:0000305}.
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DR EMBL; AC051629; AAF99837.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE29525.1; -; Genomic_DNA.
DR EMBL; BT010799; AAR24166.1; -; mRNA.
DR EMBL; BT011278; AAR92314.1; -; mRNA.
DR PIR; B86305; B86305.
DR RefSeq; NP_173139.1; NM_101556.4.
DR AlphaFoldDB; Q9FZ54; -.
DR SMR; Q9FZ54; -.
DR IntAct; Q9FZ54; 4.
DR STRING; 3702.AT1G16950.1; -.
DR PaxDb; Q9FZ54; -.
DR PRIDE; Q9FZ54; -.
DR EnsemblPlants; AT1G16950.1; AT1G16950.1; AT1G16950.
DR GeneID; 838266; -.
DR Gramene; AT1G16950.1; AT1G16950.1; AT1G16950.
DR KEGG; ath:AT1G16950; -.
DR Araport; AT1G16950; -.
DR TAIR; locus:2035515; AT1G16950.
DR HOGENOM; CLU_176522_0_0_1; -.
DR InParanoid; Q9FZ54; -.
DR OMA; PYRTSKG; -.
DR OrthoDB; 1536262at2759; -.
DR PhylomeDB; Q9FZ54; -.
DR PRO; PR:Q9FZ54; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9FZ54; baseline and differential.
DR GO; GO:0048046; C:apoplast; ISS:UniProtKB.
DR GO; GO:0005179; F:hormone activity; ISS:UniProtKB.
DR GO; GO:0006995; P:cellular response to nitrogen starvation; IEP:UniProtKB.
DR GO; GO:1902025; P:nitrate import; ISS:UniProtKB.
DR GO; GO:2000280; P:regulation of root development; ISS:UniProtKB.
DR GO; GO:0060359; P:response to ammonium ion; IEP:UniProtKB.
DR GO; GO:0009739; P:response to gibberellin; IEP:UniProtKB.
DR GO; GO:0090548; P:response to nitrate starvation; IEP:UniProtKB.
DR GO; GO:1901698; P:response to nitrogen compound; IEP:UniProtKB.
DR GO; GO:0006970; P:response to osmotic stress; IEP:UniProtKB.
DR InterPro; IPR038930; CEP13/CEP14.
DR PANTHER; PTHR37180; PTHR37180; 1.
PE 2: Evidence at transcript level;
KW Apoplast; Developmental protein; Hormone; Hydroxylation;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT PROPEP 28..78
FT /evidence="ECO:0000305"
FT /id="PRO_0000440010"
FT PEPTIDE 79..93
FT /note="C-terminally encoded peptide 13"
FT /evidence="ECO:0000250|UniProtKB:Q058G9"
FT /id="PRO_0000440011"
FT REGION 45..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..77
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 87
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:Q058G9"
FT MOD_RES 89
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:Q8L8Y3"
SQ SEQUENCE 93 AA; 9994 MW; 6CDD179FFAB8F1A8 CRC64;
MARPRISISM ICLLILIVGF VLQSSQARKV LVPYGTSKGL FLSALPKGNV PPSGPSDKGH
TSPPDDTDQR MVPENSPEIY RRLESVPSPG VGH
