ID   PCP4_BOVIN              Reviewed;          62 AA.
AC   Q148C4;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Calmodulin regulator protein PCP4 {ECO:0000305};
DE   AltName: Full=Purkinje cell protein 4;
GN   Name=PCP4 {ECO:0000250|UniProtKB:P48539};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as a modulator of calcium-binding by calmodulin.
CC       Thereby, regulates calmodulin activity and the different processes it
CC       controls. For instance, may play a role in neuronal differentiation
CC       through activation of calmodulin-dependent kinase signaling pathways.
CC       {ECO:0000250|UniProtKB:P48539}.
CC   -!- SUBUNIT: Binds to both calcium-free and calcium-bound calmodulin. The
CC       affinity for the calcium-bound form is 50-fold greater.
CC       {ECO:0000250|UniProtKB:P48539}.
CC   -!- DOMAIN: Mostly intrinsically disordered, with residual structure
CC       localized to the IQ domain which mediates the interaction with
CC       calmodulin. {ECO:0000250|UniProtKB:P48539}.
CC   -!- SIMILARITY: Belongs to the PCP4 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC118489; AAI18490.1; -; mRNA.
DR   RefSeq; NP_001071604.1; NM_001078136.1.
DR   AlphaFoldDB; Q148C4; -.
DR   SMR; Q148C4; -.
DR   PeptideAtlas; Q148C4; -.
DR   Ensembl; ENSBTAT00000078431; ENSBTAP00000067628; ENSBTAG00000051421.
DR   GeneID; 768324; -.
DR   KEGG; bta:768324; -.
DR   CTD; 5121; -.
DR   VEuPathDB; HostDB:ENSBTAG00000051421; -.
DR   VGNC; VGNC:106858; PCP4.
DR   GeneTree; ENSGT00530000064267; -.
DR   InParanoid; Q148C4; -.
DR   OMA; FQIDMDA; -.
DR   OrthoDB; 1635294at2759; -.
DR   Proteomes; UP000009136; Chromosome 1.
DR   Bgee; ENSBTAG00000051421; Expressed in prefrontal cortex and 88 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; ISS:UniProtKB.
DR   GO; GO:0005516; F:calmodulin binding; ISS:UniProtKB.
DR   GO; GO:0099004; P:calmodulin dependent kinase signaling pathway; ISS:UniProtKB.
DR   GO; GO:0045666; P:positive regulation of neuron differentiation; ISS:UniProtKB.
DR   InterPro; IPR033236; PCP4.
DR   PANTHER; PTHR15359:SF7; PTHR15359:SF7; 1.
PE   3: Inferred from homology;
KW   Calmodulin-binding; Reference proteome.
FT   CHAIN           1..62
FT                   /note="Calmodulin regulator protein PCP4"
FT                   /id="PRO_0000331439"
FT   DOMAIN          39..62
FT                   /note="IQ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          28..40
FT                   /note="Acidic; binds calcium and is required for modulating
FT                   the calcium-binding kinetics of calmodulin"
FT                   /evidence="ECO:0000250|UniProtKB:P48539"
FT   COMPBIAS        1..16
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..38
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   62 AA;  6817 MW;  9149F06DE40147D8 CRC64;
     MSERQGAGTT NGKDKPSGEN DGQKKVQEEF DIDMDAPETE RAAVAIQSQF RKFQKKKAGS
     QS