PCP4_MOUSE
ID PCP4_MOUSE Reviewed; 62 AA.
AC P63054; P07734; Q63890;
DT 01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Calmodulin regulator protein PCP4 {ECO:0000305};
DE AltName: Full=Brain-specific antigen PCP-4 {ECO:0000303|PubMed:2320430};
DE AltName: Full=Brain-specific polypeptide PEP-19 {ECO:0000303|PubMed:8361346};
DE AltName: Full=Purkinje cell protein 4 {ECO:0000312|MGI:MGI:97509};
GN Name=Pcp4 {ECO:0000312|MGI:MGI:97509}; Synonyms=Pep19;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum;
RX PubMed=2320430; DOI=10.1093/nar/18.5.1304;
RA Chen S.L., Orr H.T.;
RT "Sequence of a murine cDNA, pcp-4, that encodes the homolog of the rat
RT brain-specific antigen PEP-19.";
RL Nucleic Acids Res. 18:1304-1304(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8361346; DOI=10.1016/0169-328x(93)90149-j;
RA Sangameswaran L., Morgan J.I.;
RT "Structure and regulation of the gene encoding the neuron-specific protein
RT PEP-19.";
RL Brain Res. Mol. Brain Res. 19:62-68(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Functions as a modulator of calcium-binding by calmodulin.
CC Thereby, regulates calmodulin activity and the different processes it
CC controls. For instance, may play a role in neuronal differentiation
CC through activation of calmodulin-dependent kinase signaling pathways.
CC {ECO:0000250|UniProtKB:P48539}.
CC -!- SUBUNIT: Binds to both calcium-free and calcium-bound calmodulin. The
CC affinity for the calcium-bound form is 50-fold greater.
CC {ECO:0000250|UniProtKB:P48539}.
CC -!- DOMAIN: Mostly intrinsically disordered, with residual structure
CC localized to the IQ domain which mediates the interaction with
CC calmodulin. {ECO:0000250|UniProtKB:P48539}.
CC -!- SIMILARITY: Belongs to the PCP4 family. {ECO:0000305}.
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DR EMBL; X17320; CAA35199.1; -; mRNA.
DR EMBL; S65227; AAB28009.2; -; Genomic_DNA.
DR EMBL; S65225; AAB28009.2; JOINED; Genomic_DNA.
DR EMBL; S65226; AAB28009.2; JOINED; Genomic_DNA.
DR EMBL; BC061164; AAH61164.1; -; mRNA.
DR CCDS; CCDS37414.1; -.
DR PIR; S14925; S14925.
DR RefSeq; NP_032817.1; NM_008791.3.
DR AlphaFoldDB; P63054; -.
DR SMR; P63054; -.
DR STRING; 10090.ENSMUSP00000062539; -.
DR iPTMnet; P63054; -.
DR PhosphoSitePlus; P63054; -.
DR MaxQB; P63054; -.
DR PaxDb; P63054; -.
DR PRIDE; P63054; -.
DR ProteomicsDB; 288001; -.
DR DNASU; 18546; -.
DR Ensembl; ENSMUST00000061739; ENSMUSP00000062539; ENSMUSG00000090223.
DR GeneID; 18546; -.
DR KEGG; mmu:18546; -.
DR UCSC; uc008adc.1; mouse.
DR CTD; 5121; -.
DR MGI; MGI:97509; Pcp4.
DR VEuPathDB; HostDB:ENSMUSG00000090223; -.
DR eggNOG; ENOG502STZW; Eukaryota.
DR HOGENOM; CLU_202697_1_0_1; -.
DR InParanoid; P63054; -.
DR OMA; FQIDMDA; -.
DR OrthoDB; 1635294at2759; -.
DR PhylomeDB; P63054; -.
DR TreeFam; TF336068; -.
DR BioGRID-ORCS; 18546; 3 hits in 70 CRISPR screens.
DR ChiTaRS; Pcp4; mouse.
DR PRO; PR:P63054; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; P63054; protein.
DR Bgee; ENSMUSG00000090223; Expressed in striatum and 170 other tissues.
DR ExpressionAtlas; P63054; baseline and differential.
DR Genevisible; P63054; MM.
DR GO; GO:0030424; C:axon; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005883; C:neurofilament; ISO:MGI.
DR GO; GO:0043005; C:neuron projection; ISO:MGI.
DR GO; GO:0032991; C:protein-containing complex; ISO:MGI.
DR GO; GO:0005509; F:calcium ion binding; ISS:UniProtKB.
DR GO; GO:0005516; F:calmodulin binding; IDA:MGI.
DR GO; GO:0003723; F:RNA binding; ISO:MGI.
DR GO; GO:0099004; P:calmodulin dependent kinase signaling pathway; ISS:UniProtKB.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; ISO:MGI.
DR GO; GO:0006469; P:negative regulation of protein kinase activity; ISO:MGI.
DR GO; GO:0033603; P:positive regulation of dopamine secretion; ISO:MGI.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; ISS:UniProtKB.
DR GO; GO:0010976; P:positive regulation of neuron projection development; ISO:MGI.
DR InterPro; IPR033236; PCP4.
DR PANTHER; PTHR15359:SF7; PTHR15359:SF7; 1.
PE 3: Inferred from homology;
KW Calcium; Calmodulin-binding; Reference proteome.
FT CHAIN 1..62
FT /note="Calmodulin regulator protein PCP4"
FT /id="PRO_0000058307"
FT DOMAIN 39..62
FT /note="IQ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 28..40
FT /note="Acidic; binds calcium and is required for modulating
FT the calcium-binding kinetics of calmodulin"
FT /evidence="ECO:0000250|UniProtKB:P48539"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 40
FT /note="E -> Q (in Ref. 2; AAB28009)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 62 AA; 6807 MW; 8DF93078A15EE79D CRC64;
MSERQSAGAT NGKDKTSGDN DGQKKVQEEF DIDMDAPETE RAAVAIQSQF RKFQKKKAGS
QS
